Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Eric D. Lynch"'
Autor:
Joseph Bush, Tapan C. Patel, Michael Cary. Long, Eric D. Lynch, Eileen T. Westervelt, Stephen Briggs, Daniel A. Shepard, David M. Schwenk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3587fa438040ba4fd6e637dcf4a52c8e
https://doi.org/10.21079/11681/35294
https://doi.org/10.21079/11681/35294
Autor:
Jonathan Kil, Patrick J. Antonelli, Scott K. Griffiths, Edward Lobarinas, Christopher Spankovich, Colleen G. Le Prell, Eric D. Lynch
Publikováno v:
The Lancet. 390:969-979
Summary Background Noise-induced hearing loss is a leading cause of occupational and recreational injury and disease, and a major determinant of age-related hearing loss. No therapeutic agent has been approved for the prevention or treatment of this
Publikováno v:
Translational Research in Audiology, Neurotology, and the Hearing Sciences ISBN: 9783319408460
Current efforts to translate laboratory findings into clinical drugs for preventing or treating sensorineural hearing loss (SNHL) are reviewed in this chapter. Since no drugs have been approved for any inner ear indication involving SNHL, including t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97c887a82d45f76088fa436dc5777747
https://doi.org/10.1007/978-3-319-40848-4_5
https://doi.org/10.1007/978-3-319-40848-4_5
Publikováno v:
The Open Otorhinolaryngology Journal. 5:25-34
Background: In mammals, sensory hair cells and supporting cells that comprise the auditory epithelium (i.e. organ of Corti) lose the ability to proliferate or regenerate after embryogenesis and are considered terminally differentiated. Previously, it
Autor:
Rachel E. Klevit, Tom Walsh, Mary Claire King, Sarah B. Pierce, Eric D. Lynch, Karen M. Chisholm, John M. Opitz, Weiqing Li, Ming K. Lee
Publikováno v:
Proceedings of the National Academy of Sciences. 108:6543-6548
Perrault syndrome is a genetically heterogeneous recessive disorder characterized by ovarian dysgenesis and sensorineural hearing loss. In a nonconsanguineous family with five affected siblings, linkage analysis and genomic sequencing revealed the ge
Autor:
Eric D. Lynch, Jonathan Kil
Publikováno v:
Seminars in Hearing. 30:047-055
The development of therapeutics for the prevention and treatment of sensorineural hearing loss remains an elusive goal for auditory scientists and clinicians worldwide. While much research has focused on the histopathology associated with exposure to
Publikováno v:
Anti-Cancer Drugs. 16:569-579
The chemoprotective effects of combined ebselen and allopurinol in breast (MTLn3) and ovarian (NuTu-19) cancer models using a repeated cisplatin dosing schedule (6 mg/kg i.p.x3 weeks) were studied. Otoprotection was evaluated using auditory evoked br
Publikováno v:
Hearing Research. 201:81-89
Cisplatin ototoxicity has been associated with the generation of toxic levels of reactive oxygen species (ROS) which can lead to injury or loss of outer hair cells in the organ of Corti, damage to the stria vascularis, and loss of spiral ganglion cel
Publikováno v:
The Laryngoscope. 114:333-337
Objectives/Hypothesis: Ebselen, a glutathione peroxidase mimic, is a candidate compound for the prevention of noise-induced hearing loss. Study Design: Single-blinded, placebo-controlled study. Methods: Methods included single and repeated noise expo
Autor:
Colleen G. Le Prell, Patrick J. Antonelli, Scott K. Griffiths, Jonathan Kil, Edward Lobarinas, Eric D. Lynch, Christopher Spankovich
Publikováno v:
Otolaryngology–Head and Neck Surgery. 151
Objectives:Determine the safety and efficacy of SPI-1005, a novel oral glutathione peroxidase (GPx) mimic and inducer, in preventing and treating noise-induced hearing loss (NIHL) in adults ranging from slight hearing loss (≤25 dBHL) to normal hear