Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Eric D. Kelsic"'
Autor:
Dor Russ, Fabian Glaser, Einat Shaer Tamar, Idan Yelin, Michael Baym, Eric D. Kelsic, Claudia Zampaloni, Andreas Haldimann, Roy Kishony
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Beta-lactam antibiotics and beta-lactamase inhibitors compete for the same binding site on beta-lactamases; thus, mutations that increase beta-lactamase activity likely increase also susceptibility to the inhibitor. Here, Russ et al. identify rare mu
Externí odkaz:
https://doaj.org/article/e3d8b35e0db44a9784cca19e12812b34
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
A key hurdle to making adeno-associated virus (AAV) capsid mediated gene therapy broadly beneficial to all patients is overcoming pre-existing and therapy-induced immune responses to these vectors. Recent advances in high-throughput DNA synthesis, mu
Externí odkaz:
https://doaj.org/article/9aefd269bf8349888a2ba68db80d1c41
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
A major challenge of theoretical ecology is explaining the stable coexistence of diverse multi-species communities. Here, the authors show that when the interactions among two species depend on the presence of other species, the diversity of the comm
Externí odkaz:
https://doaj.org/article/cea643fe8b934b33891f1d8621ff3dae
Autor:
Drew Bryant, Patrick Riley, Ali Bashir, Nina Jain, Sam Sinai, Eric D. Kelsic, George M. Church, Pierce Ogden, Lucy J. Colwell
Publikováno v:
Nature Biotechnology. 39:691-696
Modern experimental technologies can assay large numbers of biological sequences, but engineered protein libraries rarely exceed the sequence diversity of natural protein families. Machine learning (ML) models trained directly on experimental data wi
Autor:
Michael H. Baym, Claudia Zampaloni, Roy Kishony, Andreas Haldimann, Fabian Glaser, Idan Yelin, Dor Russ, Eric D. Kelsic, Einat Shaer Tamar
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Beta-lactamase inhibitors are increasingly used to counteract antibiotic resistance mediated by beta-lactamase enzymes. These inhibitors compete with the beta-lactam antibiotic for the same binding site on the beta-lactamase, thus generating an evolu
SummaryAdeno-associated virus (AAV) capsids have shown clinical promise as delivery vectors for gene therapy. However, the high prevalence of pre-existing immunity against natural capsids poses a challenge for widespread treatment. The generation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdcf0958a04de7c8abec5a7f1c39ae35
https://doi.org/10.1101/2021.04.16.440236
https://doi.org/10.1101/2021.04.16.440236
Autor:
George M. Church, Eric D. Kelsic
Publikováno v:
Cell and Gene Therapy Insights. 5:523-536
Autor:
Drew H, Bryant, Ali, Bashir, Sam, Sinai, Nina K, Jain, Pierce J, Ogden, Patrick F, Riley, George M, Church, Lucy J, Colwell, Eric D, Kelsic
Publikováno v:
Nature biotechnology. 39(6)
Modern experimental technologies can assay large numbers of biological sequences, but engineered protein libraries rarely exceed the sequence diversity of natural protein families. Machine learning (ML) models trained directly on experimental data wi
Publikováno v:
Science
The fitness landscape of AAV Adeno-associated virus (AAV) is an important gene therapy vector. Using tools from synthetic biology, Ogden et al. provide a comprehensive view of how sequence changes in capsid proteins affect AAV properties. After satur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b541b24fddf7411950fd9ad1de5f7da1
https://europepmc.org/articles/PMC7197022/
https://europepmc.org/articles/PMC7197022/
Autor:
Michael H. Baym, Eric D. Kelsic, Rotem Gross, Remy Chait, Idan Yelin, Tami D. Lieberman, Roy Kishony
Publikováno v:
Science. 353:1147-1151
A key aspect of bacterial survival is the ability to evolve while migrating across spatially varying environmental challenges. Laboratory experiments, however, often study evolution in well-mixed systems. Here, we introduce an experimental device, th