Výsledky vyhledávání - "Eric D. A. Stemp"

Glutathione Directly Intercepts DNA Radicals To Inhibit Oxidative DNA–Protein Cross-Linking Induced by the One-Electron Oxidation of Guanine

Autor: Eric D. A. Stemp, Diana Esparza, Mary Safaeipour, Juliette Jauregui, Sarah Castillo, Mary Bekarian, Maritza Sanchez

Publikováno v: Biochemistry. 58:4621-4631

Oxidative DNA damage can lead to cancer, and as enzymatic DNA repair systems become compromised during the aging process, the role of exogenous antioxidants becomes more critical. Here, we examined whether such non-enzymatic DNA repair can be effecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9d50af3e9d8683b1c9662949fe8b7b
https://doi.org/10.1021/acs.biochem.9b00697

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Extracellular DNA Promotes Efficient Extracellular Electron Transfer by Pyocyanin in Pseudomonas aeruginosa Biofilms

Autor: Jacqueline K. Barton, Matthew D. Yates, Leonard M. Tender, Scott H. Saunders, Edmund C. M. Tse, Dianne K. Newman, Eric D. A. Stemp, Fernanda Jiménez Otero, Scott A. Trammell

Publikováno v: Cell

SUMMARYExtracellular electron transfer (EET), the process whereby cells access electron acceptors or donors that reside many cell lengths away, enables metabolic activity by microorganisms, particularly under oxidant-limited conditions that occur in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78547e25bb33df62dc3526fac2a5fe84
https://europepmc.org/articles/PMC7457544/

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Direct photo-induced DNA strand scission by a ruthenium bipyridyl complex

Autor: Lev Weiner, Eylon Yavin, Abraham Shanzer, Rina Arad-Yellin, Eric D. A. Stemp, Irit Sagi

Publikováno v: Journal of Inorganic Biochemistry. 98:1750-1756

Irradiation of plasmid DNA in the presence of Ru(II)-2, a modified tris(2,2'-bipyridyl)Ru(II) complex, in which two hydroxamic acid groups are attached to one of the three bipyridyl ligands, results in total fragmentation of the DNA. The photo-chemic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfe964d5f30481c17875d0db1558b61
https://doi.org/10.1016/j.jinorgbio.2004.07.016

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Direct Observation of Radical Intermediates in Protein-Dependent DNA Charge Transport

Autor: Scott R. Rajski, Hans-Achim Wagenknecht, Matthias Pascaly, Jacqueline K. Barton, Eric D. A. Stemp

Publikováno v: Journal of the American Chemical Society. 123:4400-4407

Charge migration through the DNA base stack has been probed both spectroscopically, to observe the formation of radical intermediates, and biochemically, to assess irreversible oxidative DNA damage. Charge transport and radical trapping were examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3328d3316ca77ac84b5dfd0e0a48b043
https://doi.org/10.1021/ja003986l

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DNA−Protein Cross-Linking from Oxidation of Guanine via the Flash−Quench Technique

Autor: Sara M. Butterfield, Eric D. A. Stemp, Kristina M. Nowitzki, Mary Steryo, and Suzie R. Ward, Kristina Kurbanyan, Kim L. Nguyen

Publikováno v: Journal of the American Chemical Society. 122:3585-3594

The production of guanine radicals in DNA via the flash−quench technique is shown to cause the formation of covalent adducts between DNA and histone protein. In the flash−quench experiment, the DNA-bound intercalator Ru(phen)2dppz2+ (phen = 1,10-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dcb59e798c728e82b105c18c20104534
https://doi.org/10.1021/ja993502p

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Electron transfer between metal complexes bound to DNA: variations in sequence, donor, and metal binding mode

Autor: R. Erik Holmlin, Jacqueline K. Barton, Eric D. A. Stemp

Publikováno v: Inorganica Chimica Acta. 297:88-97

Using luminescence spectroscopy and single photon counting, photoinduced electron transfer (ET) reactions between photoexcited [M(phen)_2dppz ^(2+) (phen = 1,10-phenanthroline, dppz=dipyridophenazine, M=Ru or Os) and the electron acceptors Rh(phi)_2b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7667228e55ba60c80e88f607bc512ae
https://doi.org/10.1016/s0020-1693(99)00289-3

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Evidence of Electron Transfer from Peptides to DNA: Oxidation of DNA-Bound Tryptophan Using the Flash-Quench Technique

Autor: Eric D. A. Stemp, Jacqueline K. Barton, Hans-Achim Wagenknecht

Publikováno v: Journal of the American Chemical Society. 122:1-7

A flash-quench method has been employed to probe electron-transfer reactions from peptides to DNA. The photoexcited intercalators [Ru(phen)2(dppz)]2+ (phen = 1,10-phenanthroline; dppz = dipyridophenazine) and [Ru(phen)(bpy‘)(dppz)]2+ (bpy‘ = 4-(4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a3ff0a6c27bc0e0a8242fca1d450d56
https://doi.org/10.1021/ja991855i

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