Uncertainty quantification in ToxCast high throughput screening.

Autor: Eric D Watt, Richard S Judson

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0196963 (2018)

High throughput screening (HTS) projects like the U.S. Environmental Protection Agency's ToxCast program are required to address the large and rapidly increasing number of chemicals for which we have little to no toxicity measurements. Concentration-

Externí odkaz: https://doaj.org/article/c9e466ef712141b4b12a6b168b23ef71

Early Drug-Induced Liver Injury Risk Screening: 'Free,' as Good as It Gets

Autor: Matthew T Martin, Petra Koza-Taylor, Li Di, Eric D Watt, Christopher Keefer, Daniel Smaltz, Jon Cook, Jonathan P Jackson

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 188(2)

For all the promise of and need for clinical drug-induced liver injury (DILI) risk screening systems, demonstrating the predictive value of these systems versus readily available physicochemical properties and inherent dosing information has not been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266653436636e018175265033995f4a8
https://pubmed.ncbi.nlm.nih.gov/35639956

Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters

Autor: Stephen Jenkinson, Dingzhou Li, David J. MacEwan, Peter Kilfoil, Eric D. Watt, Derek J. Leishman, Parveen Sharma, Tiffany Lee, Asser Bassyouni, Shuyun Lily Feng

Publikováno v: European Journal of Pharmacology

Human induced pluripotent stem cell derived cardiomyocytes (hIPSC-CM's) play an increasingly important role in the safety profiling of candidate drugs. For such models to have utility a clear understanding of clinical translation is required. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354b5671ca62b0aeeb7522f5069bc852
https://pubmed.ncbi.nlm.nih.gov/34678241

QSAR models for thyroperoxidase inhibition and screening of U.S. and EU chemical inventories

Autor: Steven O. Simmons, Sine Abildgaard Rosenberg, Marianne Dybdahl, Eva Bay Wedebye, Richard S. Judson, Nikolai Georgiev Nikolov, K. Paul Friedman, Eric D. Watt

Publikováno v: Abildgaard Rosenberg, S, D. Watt, E, Judson, R S, Simmons, S O, Paul Friedmann, K, Dybdahl, M, Nikolov, N G & Wedebye, E B 2017, ' QSAR Models for Thyroperoxidase Inhibition and Screening of U.S. and EU Chemical Inventories ', Computational Toxicology, vol. 4, pp. 11-21 . https://doi.org/10.1016/j.comtox.2017.07.006

Thyroperoxidase (TPO) is the enzyme that synthesizes thyroid hormones (THs). TPO inhibition by chemicals can result in decreased TH levels and developmental neurotoxicity, and therefore identification of TPO inhibition is of high relevance in safety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a53043d96ecf0754a85524f094f0b50f
https://doi.org/10.1016/j.comtox.2017.07.006

Uncertainty quantification in ToxCast high throughput screening

Autor: Richard S. Judson, Eric D. Watt

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0196963 (2018)
PLoS ONE

High throughput screening (HTS) projects like the U.S. Environmental Protection Agency's ToxCast program are required to address the large and rapidly increasing number of chemicals for which we have little to no toxicity measurements. Concentration-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a71c3b254ac5580862665fc8f59ad3
http://europepmc.org/articles/PMC6059398?pdf=render