Zobrazeno 1 - 10
of 445
pro vyhledávání: '"Eric D Brown"'
Autor:
Kenneth Rachwalski, Sean J. Madden, Nicole Ritchie, Shawn French, Timsy Bhando, Adele Girgis-Gabardo, Megan Tu, Rodion Gordzevich, Rowan Ives, Amelia B.Y. Guo, Jarrod W. Johnson, Yiming Xu, Sharookh B. Kapadia, Jakob Magolan, Eric D. Brown
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110894- (2024)
Summary: The increasing prevalence of antibiotic resistance demands the discovery of antibacterial chemical scaffolds with unique mechanisms of action. Phenotypic screening approaches, such as the use of reporters for bacterial cell stress, offer pro
Externí odkaz:
https://doaj.org/article/632df03525ba4e1abf66b25ee4e9f31f
Autor:
Shawna Zhu, Mary Kate Alexander, Telmo O. Paiva, Kenneth Rachwalski, Anh Miu, Yiming Xu, Vishal Verma, Mike Reichelt, Yves F. Dufrêne, Eric D. Brown, Georgina Cox
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109592- (2024)
Summary: The Escherichia coli outer membrane channel TolC complexes with several inner membrane efflux pumps to export compounds across the cell envelope. All components of these complexes are essential for robust efflux activity, yet E. coli is more
Externí odkaz:
https://doaj.org/article/d3e67c91d4b449098b626ba5898e7760
Autor:
Shawn French, Amelia Bing Ya Guo, Michael J. Ellis, Julia P. Deisinger, Jarrod W. Johnson, Kenneth Rachwalski, Zoë A. Piquette, Telmah Lluka, Miranda Zary, Sineli Gamage, Jakob Magolan, Eric D. Brown
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114053- (2024)
Summary: In the search for much-needed new antibacterial chemical matter, a myriad of compounds have been reported in academic and pharmaceutical screening endeavors. Only a small fraction of these, however, are characterized with respect to mechanis
Externí odkaz:
https://doaj.org/article/8379235328b9489c8577896cefbc3713
Autor:
Keaton W. Smith, Brian P. Alcock, Shawn French, Maya A. Farha, Amogelang R. Raphenya, Eric D. Brown, Andrew G. McArthur
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Resistance-modifying agents have been historically underrepresented in the Comprehensive Antibiotic Resistance Database (CARD). In the process of curating over 60 new molecules into CARD’s Antibiotic Resistance Ontology, the limitations of
Externí odkaz:
https://doaj.org/article/bab09d136546404591c464ef06b4ba47
Publikováno v:
PLoS Genetics, Vol 19, Iss 11, p e1011013 (2023)
Exposure of Escherichia coli to sub-inhibitory antibiotics stimulates biofilm formation through poorly characterized mechanisms. Using a high-throughput Congo Red binding assay to report on biofilm matrix production, we screened ~4000 E. coli K12 del
Externí odkaz:
https://doaj.org/article/219b9c932b9c436894edc9f73b9e9b6f
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Over the past 20 years, we have learned that bacterial small noncoding RNAs (sRNAs) can rapidly effect changes in gene expression in response to stress. However, the broader role and impact of sRNA-mediated regulation in promoting bacterial
Externí odkaz:
https://doaj.org/article/f0a520d2e8cf403897b6f7779cc37c96
Autor:
Lindsey A. Carfrae, Eric D. Brown
Publikováno v:
Trends in Microbiology. 31:571-585
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e989a8c0762f8ee8293b95fbbce1276c
https://doi.org/10.1016/j.tim.2023.01.002
https://doi.org/10.1016/j.tim.2023.01.002
Autor:
Kristoffer T. Bæk, Camilla Jensen, Maya A. Farha, Tobias K. Nielsen, Ervin Paknejadi, Viktor H. Mebus, Martin Vestergaard, Eric D. Brown, Dorte Frees
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Staphylococcus aureus is a leading cause of bacterial infections world-wide. Staphylococcal infections are preferentially treated with β-lactam antibiotics, however, methicillin-resistant S. aureus (MRSA) strains have acquired resistance to this sup
Externí odkaz:
https://doaj.org/article/599a7e657878488191ef94e3180e68e1
Autor:
Michael J. Ellis, Caressa N. Tsai, Jarrod W. Johnson, Shawn French, Wael Elhenawy, Steffen Porwollik, Helene Andrews-Polymenis, Michael McClelland, Jakob Magolan, Brian K. Coombes, Eric D. Brown
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Salmonella Typhimurium replicates within host phagocytes. Here, the authors show that a known psychoactive drug (metergoline) inhibits growth of the pathogen in macrophages, disrupts the proton motive force at the bacterial cytoplasmic membrane, and
Externí odkaz:
https://doaj.org/article/d85977a7a0ee4df7ad240d73758c419e
Autor:
Noor Abu Jarad, Kenneth Rachwalski, Fereshteh Bayat, Shadman Khan, Amid Shakeri, Roderick MacLachlan, Martin Villegas, Eric D. Brown, Zeinab Hosseinidoust, Tohid F. Didar, Leyla Soleymani
Publikováno v:
ACS Applied Materials & Interfaces. 15:16253-16265
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5855b0b5974b304dbeac62f514a940b
https://doi.org/10.1021/acsami.2c23119
https://doi.org/10.1021/acsami.2c23119