Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Eric Conway"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Chromatin is spatially and temporally regulated through a series of orchestrated processes resulting in the formation of 3D chromatin structures such as topologically associating domains (TADs), loops and Polycomb Bodies. These structures are closely
Externí odkaz:
https://doaj.org/article/a717e715b7734d5696544481f297bf37
Publikováno v:
Trends in Genetics. 38:333-352
Cell identity is tightly controlled by specific transcriptional programs which require post-translational modifications of histones. These histone modifications allow the establishment and maintenance of active and repressed chromatin domains. Histon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09dbcf87957b73498eed545e7f1672e3
https://doi.org/10.1016/j.tig.2021.07.011
https://doi.org/10.1016/j.tig.2021.07.011
Autor:
Evan Healy, Rachel McCole, Craig Monger, James Nolan, Eric Conway, Gerard Brien, Cheng Wang, Hannah K Neikes, Frances Potjewyd, Michiel Vermeulen, Aoibhinn Mooney, Richard Flavin, Elisabeth Vandenberghe, Lindsey I James, Adrian P Bracken
Publikováno v:
Blood. 140:3049-3050
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44c9651fb0db21287f8232f912995beb
https://doi.org/10.1182/blood-2022-168762
https://doi.org/10.1182/blood-2022-168762
Autor:
Simone Tamburri, Eleonora Ponzo, Federico Rossi, Marika Zanotti, Simona Rodighiero, Diego Pasini, Daria Manganaro, Karin Johanna Ferrari, Daniel Fernández-Pérez, Eric Conway
Publikováno v:
Molecular Cell
Summary BAP1 is mutated or deleted in many cancer types, including mesothelioma, uveal melanoma, and cholangiocarcinoma. It is the catalytic subunit of the PR-DUB complex, which removes PRC1-mediated H2AK119ub1, essential for maintaining transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ed4cfe3006157ef0b911f7e9c253c92
https://hdl.handle.net/2434/946749
https://hdl.handle.net/2434/946749
Autor:
Eric Conway, Federico Rossi, Daria Manganaro, Diego Pasini, Karin Johanna Ferrari, Simona Rodighiero, Simone Tamburri, Ponzo E, Marika Zanotti, Daniel Fernández-Pérez
BAP1 is recurrently mutated or deleted in a large number of diverse cancer types, including mesothelioma, uveal melanoma and hepatocellular cholangiocarcinoma. BAP1 is the catalytic subunit of the Polycomb Repressive De-Ubiquitination complex (PR-DUB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00bee35bc4a48cc93dc4363c7e0d1299
https://doi.org/10.1101/2020.12.10.419309
https://doi.org/10.1101/2020.12.10.419309
Autor:
Eric Conway, Daniel Fernández-Pérez, Marika Zanotti, Simone Tamburri, Diego Pasini, Elisa Lavarone, Daria Manganaro
Publikováno v:
Molecular Cell
The major function of Polycomb group proteins (PcG) is to maintain transcriptional repression to preserve cellular identity. This is exerted by two distinct repressive complexes, PRC1 and PRC2, that modify histones by depositing H2AK119ub1 and H3K27m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c0ddc26949b3c247b28ab99c0b3e98
https://doi.org/10.1101/690461
https://doi.org/10.1101/690461
Autor:
Evan Healy, Raphaël Margueron, Aoife McLysaght, Haruhiko Koseki, Luciano Di Croce, Darren J. Fitzpatrick, Emilia Jerman, Orla Deevy, Manabu Nakayama, Kieran Wynne, Giorgio Oliviero, Gundula Streubel, Karsten Hokamp, Adrian P. Bracken, Claudio Ciferri, Ariane Watson, Indigo Pratt-Kelly, Christine S. Huang, Paul Chammas, Marlena Mucha, Tomoyuki Ishikura, Eleanor Glancy, Gerard Cagney, Eric Conway, Shinsuke Ito, Alan M. Rice, Daniel Holoch, Yoko Koseki
Publikováno v:
Molecular cell. 70(3)
Summary The polycomb repressive complex 2 (PRC2) consists of core subunits SUZ12, EED, RBBP4/7, and EZH1/2 and is responsible for mono-, di-, and tri-methylation of lysine 27 on histone H3. Whereas two distinct forms exist, PRC2.1 (containing one pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4179141cf8e1b95e071708f3f803bc6
https://pubmed.ncbi.nlm.nih.gov/29628311
https://pubmed.ncbi.nlm.nih.gov/29628311
Autor:
Adrian P. Bracken, Ariane Watson, Eleanor Glancy, Giorgio Oliviero, Sriganesh Jammula, Gerard Cagney, Gundula Streubel, Eric Conway, Rachel McCole, Kieran Wynne, Nevan J. Krogan, Andrea Scelfo, Diego Pasini, Eugene T. Dillon, Gian Luca Negri, Darren J. Fitzpatrick
Publikováno v:
Molecular cell. 70(2)
The Polycomb repressor complex 2 (PRC2) is composed of the core subunits Ezh1/2, Suz12, and Eed, and it mediates all di- and tri-methylation of histone H3 at lysine 27 in higher eukaryotes. However, little is known about how the catalytic activity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::426470dd83132316d67d11fade8026d8
https://pubmed.ncbi.nlm.nih.gov/29606589
https://pubmed.ncbi.nlm.nih.gov/29606589
Publikováno v:
Current opinion in cell biology. 37
The Polycomb Repressive Complex 2 (PRC2) is a multiprotein chromatin modifying complex that is essential for vertebrate development and differentiation. It is composed of a trimeric core of SUZ12, EED and EZH1/2 and is responsible for catalysing both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33ff4bc3f980ae01ddedaf1f616f9c3
https://pubmed.ncbi.nlm.nih.gov/26497635
https://pubmed.ncbi.nlm.nih.gov/26497635
Autor:
Elisa Fadda, Eric Conway, Aoife McLysaght, Adrian P. Bracken, Emilia Jerman, Scott A. Armstrong, Conor J. Kearney, Alan M. Rice, Andrei V. Krivtsov, David J. O'Connell, Simon S. McDade, Evan Healy, Gerard L. Brien, Darragh O'Donovan, Andrew Flaus, Seamus J. Martin
Publikováno v:
Genesdevelopment. 29(21)
Polycomb-like proteins 1–3 (PCL1–3) are substoichiometric components of the Polycomb-repressive complex 2 (PRC2) that are essential for association of the complex with chromatin. However, it remains unclear why three proteins with such apparent f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee123bebcef13312e904991ed6a3ccc
https://pubmed.ncbi.nlm.nih.gov/26494712
https://pubmed.ncbi.nlm.nih.gov/26494712