Zobrazeno 1 - 10 of 85 pro vyhledávání: '"Eric Ciamporcero"'
1
Akademický článek
OMO-1 reduces progression and enhances cisplatin efficacy in a 4T1-based non-c-MET addicted intraductal mouse model for triple-negative breast cancer
Autor: Jonas Steenbrugge, Niels Vander Elst, Kristel Demeyere, Olivier De Wever, Niek N. Sanders, Wim Van Den Broeck, Eric Ciamporcero, Timothy Perera, Evelyne Meyer
Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract c-MET is considered a driver of cancer progression, impacting tumor growth and tumor-supporting stroma. Here, we investigated the therapeutic efficacy of OMO-1, a potent and selective c-MET inhibitor, in an immunocompetent intraductal mouse
Externí odkaz: https://doaj.org/article/b9aac903f53b496da8763625e4385c99
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2
Akademický článek
Dll4 blockade potentiates the anti-tumor effects of VEGF inhibition in renal cell carcinoma patient-derived xenografts.
Autor: Kiersten Marie Miles, Mukund Seshadri, Eric Ciamporcero, Remi Adelaiye, Bryan Gillard, Paula Sotomayor, Kristopher Attwood, Li Shen, Dylan Conroy, Frank Kuhnert, Alshad S Lalani, Gavin Thurston, Roberto Pili
Publikováno v: PLoS ONE, Vol 9, Iss 11, p e112371 (2014)
The Notch ligand Delta-like 4 (Dll4) is highly expressed in vascular endothelium and has been shown to play a pivotal role in regulating tumor angiogenesis. Blockade of the Dll4-Notch pathway in preclinical cancer models has been associated with non-
Externí odkaz: https://doaj.org/article/2488dbb8c8394714a9609a786cc14fe3
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3
Akademický článek
Rosiglitazone and AS601245 decrease cell adhesion and migration through modulation of specific gene expression in human colon cancer cells.
Autor: Angelo Cerbone, Cristina Toaldo, Rosalba Minelli, Eric Ciamporcero, Stefania Pizzimenti, Piergiorgio Pettazzoni, Guglielmo Roma, Mario Umberto Dianzani, Chiara Ullio, Carlo Ferretti, Chiara Dianzani, Giuseppina Barrera
Publikováno v: PLoS ONE, Vol 7, Iss 6, p e40149 (2012)
PPARs are nuclear receptors activated by ligands. Activation of PPARγ leads to a reduction of adhesion and motility in some cancer models. PPARγ transcriptional activity can be negatively regulated by JNK-mediated phosphorylation. We postulated tha
Externí odkaz: https://doaj.org/article/d74e65c3254f4da1b382df1120c24ae0
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4
Akademický článek
AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells
Autor: Angelo Cerbone, Cristina Toaldo, Stefania Pizzimenti, Piergiorgio Pettazzoni, Chiara Dianzani, Rosalba Minelli, Eric Ciamporcero, Guglielmo Roma, Mario Umberto Dianzani, Roberto Canaparo, Carlo Ferretti, Giuseppina Barrera
Publikováno v: PPAR Research, Vol 2012 (2012)
PPARαs are nuclear receptors highly expressed in colon cells. They can be activated by the fibrates (clofibrate, ciprofibrate etc.) used to treat hyperlipidemia. Since PPARα transcriptional activity can be negatively regulated by JNK, the inhibitio
Externí odkaz: https://doaj.org/article/e6cc84be3dbc471cbf04ecf000cbe337
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