Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation

Autor: Nicolas Fasel, Aubry Tardivel, Kendle M. Maslowski, Pascal Schneider, Vijay G. Sankaran, Martina Stilinovic, Eric Chi-Wang Yu, Nicola Andina, Vijaykumar Chennupati, Michel A. Duchosal, Diogo F.T. Veiga, Cedric Simillion, H. Robson MacDonald, Trang Hoang, Anne Angelillo-Scherrer, Irene Roberts, Ramanjaneyulu Allam, Manfredo Quadroni

Publikováno v: The Journal of Clinical Investigation, vol. 128, no. 4, pp. 1597-1614
Chennupati, Vijaykumar; Veiga, Diogo Ft; Maslowski, Kendle M; Andina, Nicola; Tardivel, Aubry Bernard Maurice; Yu, Eric Chi-Wang; Stilinovic, Martina; Simillion, Cedric; Duchosal, Michel A; Quadroni, Manfredo; Roberts, Irene; Sankaran, Vijay G; MacDonald, H Robson; Fasel, Nicolas; Angelillo, Anne; Schneider, Pascal; Hoang, Trang; Allam, Ramanjaneyulu (2018). Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation. Journal of clinical investigation, 128(4), pp. 1597-1614. American Society for Clinical Investigation 10.1172/JCI94956

Ribosomal proteins (RP) regulate specific gene expression by selectively translating subsets of mRNAs. Indeed, in Diamond–Blackfan anaemia and 5q- syndrome, mutations in RP genes lead to a specific defect in erythroid gene translation and cause ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d084b449dacab18938c2ccb74095147b
https://serval.unil.ch/resource/serval:BIB_1F54AD670B3B.P001/REF.pdf

Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation

Autor: Michael Croft, Michael Way, Shu-ichi Matsuzawa, Robert C. Liddington, Naran Gombosuren, Arnold C. Satterthwait, Antonio Postigo, Maryla Krajewska, John C. Reed, Motti Gerlic, Rachel Flynn, Shahram Salek-Ardakani, Martina Proell, Benjamin Faustin, Eric Chi-Wang Yu

Publikováno v: Proceedings of the National Academy of Sciences. 110:7808-7813

Host innate immune responses to DNA viruses involve members of the nucleotide-binding domain, leucine-rich repeat and pyrin domain containing protein (NLRP) family, which form “inflammasomes” that activate caspase-1, resulting in proteolytic acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340947d293d862900c480a06a3fb68a6
https://doi.org/10.1073/pnas.1215995110

Association of the Small GTPase Rheb with the NMDA Receptor Subunit NR3A

Autor: Bo Xiao, Nikolaus J. Sucher, Shing Fai Chan, Frances E. Jensen, Paul F. Worley, Mitra Miri, Eric Chi-Wang Yu, Benjamin J. Lee

Publikováno v: Neurosignals. 18:203-209

The NMDAR subunit NR3A is most highly expressed during the second postnatal week, when synaptogenesis reaches peak levels. Genetic ablation or overexpression of the NR3A subunit negatively interferes with the maturation of cortical synapses and leads

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c38f3861f2c2ce97d1a6f9b4c48a16
https://doi.org/10.1159/000322206

Structural Determinants of Caspase-9 Inhibition by the Vaccinia Virus Protein, F1L*

Autor: Motti Gerlic, John C. Reed, Chaofang Jin, Eric Chi-Wang Yu, Dayong Zhai, Robert C. Liddington

In multicellular organisms, apoptosis is a powerful method of host defense against viral infection. Apoptosis is mediated by a cascade of caspase-family proteases that commit infected cells to a form of programmed cell death. Therefore, to replicate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c09febea29a53eb81be3564cc8804e
https://europepmc.org/articles/PMC3162436/

The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies

Autor: Eric Chi-Wang Yu, Marilisa Leone, Robert C. Liddington, Elena B. Pasquale, Maurizio Pellecchia

Publikováno v: Biopolymers
89 (2008): 86–92. doi:10.1002/bip.20862
info:cnr-pdr/source/autori:Leone M, Yu EC, Liddington RC, Pasquale EB, Pellecchia M./titolo:The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies./doi:10.1002%2Fbip.20862/rivista:Biopolymers (Print)/anno:2008/pagina_da:86/pagina_a:92/intervallo_pagine:86–92/volume:89

Tensin is a protein confined at those discrete and specialized regions of the plasma membrane, known as focal adhesions. It contains, at the C-terminus, a phosphotyrosine binding (PTB) domain that can interact with the cytoplasmic tail of beta-integr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a3c8201a5e325e98b8881a086285f9
https://pubmed.ncbi.nlm.nih.gov/17922498