α7 Neuronal Nicotinic Acetylcholine Receptors Are Negatively Regulated by Tyrosine Phosphorylation and Src-Family Kinases

Autor: Christian Fuhrer, Jean-Charles Hoda, R. Ogier, Andreas Wiesner, Mario Raggenbass, Geraldine Allaman, Eric Charpantier, Dominik Feuerbach, Daniel Bertrand, Kyung-Hye Huh

Publikováno v: Journal of Neuroscience, Vol. 25, No 43 (2005) pp. 9836-9849

Nicotine, a component of tobacco, is highly addictive but possesses beneficial properties such as cognitive improvements and memory maintenance. Involved in these processes is the neuronal nicotinic acetylcholine receptor (nAChR) α7, whose activatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4537d4e37a7df3b06ff3f56ecf5cbbe2
https://doi.org/10.1523/jneurosci.3497-05.2005

Candoxin, a Novel Toxin from Bungarus candidus, Is a Reversible Antagonist of Muscle (αβγδ) but a Poorly Reversible Antagonist of Neuronal α7 Nicotinic Acetylcholine Receptors

Autor: Li-Sam Cheah, Ponnampalam Gopalakrishnakone, R. Manjunatha Kini, Hoon Eng Khoo, Daniel Bertrand, Matthew C.E. Gwee, Eric Charpantier, Selvanayagam Nirthanan

Publikováno v: Journal of Biological Chemistry. 277:17811-17820

In contrast to most short and long chain curaremimetic neurotoxins that produce virtually irreversible neuromuscular blockade in isolated nerve-muscle preparations, candoxin, a novel three-finger toxin from the Malayan krait Bungarus candidus, produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c288c35b42879bbe464cc98dfbe9c72
https://doi.org/10.1074/jbc.m111152200

Diminution of nicotinic receptor alpha 3 subunit mRNA expression in aged rat brain

Autor: François Besnard, Frédéric Sgard, Eric Charpantier, David I. Graham

Publikováno v: Developmental Brain Research. 118:153-158

Losses in nicotinic acetylcholine receptors (nAChRs) have been linked to a decline in cognitive function in patients with neurodegenerative diseases, but the impact of normal aging on the different neuronal nicotinic receptor subunits has yet to be f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7e1822aed46c817fb525ac304881f2
https://doi.org/10.1016/s0165-3806(99)00157-1

Cx36 makes channels coupling human pancreatic β-cells, and correlates with insulin expression

Autor: Benoit R. Gauthier, Laurence Zulianello, Eric Charpantier, Thierry Berney, Paolo Meda, Dorothée Caille, Piero Marchetti, Ben N G Giepmans, Anne Charollais, Vincenzo Cirulli, Véronique Serre-Beinier, Giuseppe R. Diaferia, Shaoping Deng, Domenico Bosco, Leo Buhler, Roberto Lupi

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Human molecular genetics, Vol. 18, No 3 (2009) pp. 428-39
Human Molecular Genetics
Human Molecular Genetics; Vol 18
Human Molecular Genetics, 18(3), 428-439. Oxford University Press

Previous studies have documented that the insulin-producing beta-cells of laboratory rodents are coupled by gap junction channels made solely of the connexin36 (Cx36) protein, and have shown that loss of this protein desynchronizes beta-cells, leadin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f5c1c19c3bdd8966ff8381f2bc08ff
http://hdl.handle.net/10261/270659

Beta cells preferentially exchange cationic molecules via connexin 36 gap junction channels

Autor: José Antonio Cancela, Eric Charpantier, Paolo Meda

Publikováno v: Diabetologia. 50(11)

Aims/hypothesis: Pancreatic beta cells are connected by gap junction channels made of connexin 36 (Cx36), which permit intercellular exchanges of current-carrying ions (ionic coupling) and other molecules (metabolic coupling). Previous studies have s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7235b0679929055bd6cf00b077d045
https://pubmed.ncbi.nlm.nih.gov/17828386