Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Eric C. Lai"'
Autor:
Seungjae Lee, Yen-Chung Chen, FCA Consortium, Austin E. Gillen, J. Matthew Taliaferro, Bart Deplancke, Hongjie Li, Eric C. Lai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Single cell data provides cellular resolution on gene expression, but is rarely mined for isoforms. Analysis of 3' isoforms across ~250 Drosophila cell types reveals the cellular bases for numerous tissue-specific 3' programs, identifies new 3' progr
Externí odkaz:
https://doaj.org/article/819428a6b3ea4eb7910be5712585850b
Autor:
Seungjae Lee, David Jee, Sid Srivastava, Acong Yang, Abhinav Ramidi, Renfu Shang, Diane Bortolamiol-Becet, Sébastien Pfeffer, Shuo Gu, Jiayu Wen, Eric C. Lai
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112111- (2023)
Summary: Canonical microRNA (miRNA) hairpins are processed by the RNase III enzymes Drosha and Dicer into ∼22 nt RNAs loaded into an Argonaute (Ago) effector. In addition, splicing generates numerous intronic hairpins that bypass Drosha (mirtrons)
Externí odkaz:
https://doaj.org/article/e5a6e87b637141948837c14c388a3164
Autor:
Lijuan Kan, Stanislav Ott, Brian Joseph, Eun Sil Park, Wei Dai, Ralph E. Kleiner, Adam Claridge-Chang, Eric C. Lai
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Epitranscriptomic modifications can regulate learning and memory. Here, the authors provide proteomic and functional analysis of N6-methyladenosine (m6A)-binding proteins in D. melanogaster and unveil behavioral and regulatory defects for m6A/Ythdf m
Externí odkaz:
https://doaj.org/article/39d140120489475e99f3279baf323698
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
XPO5 mediates nuclear export of miRNA hairpin precursors (pre-miRNAs) through a RanGTP-dependent binding. Here the authors employ HITS-CLIP and biochemical analysis and show that XPO5 binds and promotes nuclear processing of clustered pri-miRNAs, wit
Externí odkaz:
https://doaj.org/article/e5599e5636e1449f8fedcdac30d97247
Autor:
Lu Wei, Eric C. Lai
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The process of alternative polyadenylation (APA) generates multiple 3' UTR isoforms for a given locus, which can alter regulatory capacity and on occasion change coding potential. APA was initially characterized for a few genes, but in the past decad
Externí odkaz:
https://doaj.org/article/bfef7d22d6af4f879ce424bdfd2bd02f
Autor:
Malin Ueberschär, Huazhen Wang, Chun Zhang, Shu Kondo, Tsutomu Aoki, Paul Schedl, Eric C. Lai, Jiayu Wen, Qi Dai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The BEN-solo proteins—including Insensitive (Insv), Elba1 and Elba2—function in both transcriptional repression and chromatin insulation. Here, the authors investigate the role of these proteins in Drosophila embryos, finding that ELBA and Insv f
Externí odkaz:
https://doaj.org/article/1d3734f528d84257b773408e540437b6
Autor:
Fernando Bejarano, Eric C. Lai
Publikováno v:
Data in Brief, Vol 36, Iss , Pp 107037- (2021)
microRNAs (miRNAs) are a broad class of ~22 nucleotide regulatory RNA, which collectively have broad effects on the transcriptome and are involved in diverse biology, from development and adult physiology, and from homeostasis to disease and patholog
Externí odkaz:
https://doaj.org/article/703b33aa3ec5490ab292f5b70356aa6b
Autor:
Jeffrey Vedanayagam, Walid K. Chatila, Bülent Arman Aksoy, Sonali Majumdar, Anders Jacobsen Skanderup, Emek Demir, Nikolaus Schultz, Chris Sander, Eric C. Lai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
DICER is involved in the processing of miRNAs, where the RNase IIIa and IIIb domains are thought to cut the 3p and 5p hairpin arms, respectively. Here, in endometrial cancer, the authors identify an RNase IIIa mutation, which phenocopies mutations in
Externí odkaz:
https://doaj.org/article/2f755b2a10804cc9b94ebb7187c03ce0
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Distinct mammalian RNA viruses trigger Dicer-mediated production of virus-derived small-interfering RNAs (vsiRNA) and encode unrelated proteins to suppress vsiRNA biogenesis. However, the mechanism and function of the mammalian RNA interfere
Externí odkaz:
https://doaj.org/article/767fc406aa104dc1887423b76495308b
Autor:
Virginia Teijeiro, Dapeng Yang, Sonali Majumdar, Federico González, Robert W. Rickert, Chunlong Xu, Richard Koche, Nipun Verma, Eric C. Lai, Danwei Huangfu
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 616-625 (2018)
Summary: MicroRNAs (miRNAs) are the effectors of a conserved gene-silencing system with broad roles in post-transcriptional regulation. Due to functional overlaps, assigning specific functions to individual miRNAs has been challenging. DICER1 cleaves
Externí odkaz:
https://doaj.org/article/d7dd2ff28169429499d9a5efd8d090f0