Výsledky vyhledávání - "Eric C. Hales"

Akademický článek

Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11

Autor: Jeremiah N. Shields, Eric C. Hales, Lillian E. Ranspach, Xixia Luo, Steven Orr, Donna Runft, Alan Dombkowski, Melody N. Neely, Larry H. Matherly, Jeffrey Taub, Tracie R. Baker, Ryan Thummel

Publikováno v: Toxics, Vol 7, Iss 4, p 50 (2019)

Recent studies suggest that organophosphates and carbamates affect human fetal development, resulting in neurological and growth impairment. However, these studies are conflicting and the extent of adverse effects due to pesticide exposure warrants f

Externí odkaz: https://doaj.org/article/0bffc0801d654e71a429aecd7ebb3528

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New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

Autor: Eric C. Hales, Jeffrey W. Taub, Larry H. Matherly

Publikováno v: Cellular Signalling. 26:149-161

T-cell acute lymphoblastic leukemia (T-ALL) is characterized as a high-risk stratified disease associated with frequent relapse, chemotherapy resistance, and a poorer prognostic outlook than B-precursor ALL. Many of the challenges in treating T-ALL r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4070afcdb2e1f8641b0394efe8e7124
https://doi.org/10.1016/j.cellsig.2013.09.021

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Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11

Autor: Eric C. Hales, Donna L. Runft, Larry H. Matherly, Ryan Thummel, Melody N. Neely, Alan A. Dombkowski, Tracie R. Baker, Jeremiah N. Shields, Xixia Luo, Steven Orr, Jeffrey W. Taub, Lillian E. Ranspach

Publikováno v: Toxics, Vol 7, Iss 4, p 50 (2019)
Toxics
Volume 7
Issue 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd53e93756a30b03720c79728198dd9f
https://doi.org/10.3390/toxics7040050

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Discovery of 5-Substituted Pyrrolo[2,3-d]pyrimidine Antifolates as Dual-Acting Inhibitors of Glycinamide Ribonucleotide Formyltransferase and 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase in De Novo Purine Nucleotide Biosynthesis: Implications of Inhibiting 5-Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase to AMPK Activation and Antitumor Activity

Autor: Aleem Gangjee, Manasa P. Ravindra, Shermaine Mitchell-Ryan, Larry H. Matherly, Steven Orr, Eric C. Hales, Sudhir Raghavan, Christina Cherian, Zhanjun Hou, Yiqiang Wang

Publikováno v: Journal of Medicinal Chemistry. 56:10016-10032

We synthesized 5-substituted pyrrolo[2,3-d]pyrimidine antifolates (compounds 5-10) with one-to-six bridge carbons and a benozyl ring in the side chain as antitumor agents. Compound 8 with a 4-carbon bridge was the most active analogue and potently in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04814daf7076b8793492dfa4f0b9b0fe
https://doi.org/10.1021/jm401328u

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Notch1 Receptor Regulates AKT Protein Activation Loop (Thr308) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells

Autor: Steven Orr, Jeffrey W. Taub, Larry H. Matherly, Amanda Larson Gedman, Eric C. Hales

Publikováno v: Journal of Biological Chemistry. 288:22836-22848

Notch1 activating mutations occur in more than 50% of T-cell acute lymphoblastic leukemia (T-ALL) cases and increase expression of Notch1 target genes, some of which activate AKT. HES1 transcriptionally silences phosphatase and tensin homolog (PTEN),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3282cc74716dcbda6e6caeddf00d83f2
https://doi.org/10.1074/jbc.m113.451625

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Therapeutic Targeting of a Novel 6-Substituted Pyrrolo [2,3-d]pyrimidine Thienoyl Antifolate to Human Solid Tumors Based on Selective Uptake by the Proton-Coupled Folate Transporter

Autor: Sita Kugel Desmoulin, Aleem Gangjee, Christina Cherian, Juiwanna Kushner, Eric C. Hales, Larry H. Matherly, Lisa Polin, Lei Wang, Kathryn White, Zhanjun Hou, Mark Stout

Publikováno v: Molecular Pharmacology. 80:1096-1107

The proton-coupled folate transporter (PCFT) is a proton-folate symporter with an acidic pH optimum. By real-time reverse transcription-polymerase chain reaction, PCFT was expressed in the majority of 53 human tumor cell lines, with the highest level

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf1855c3ef246d33626cf1627a5e298
https://doi.org/10.1124/mol.111.073833

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Abstract 4116: Notch1 regulates AKT-T308 dephosphorylation through modulation of the PP2A phosphatase in GSI-resistant T-cell acute lymphoblastic leukemia (T-ALL) cells

Autor: Eric C. Hales, Amanda Larson Gedman, Jeffrey W. Taub, Steven Orr, Larry H. Matherly

Publikováno v: Cancer Research. 73:4116-4116

Pediatric T-ALL typically has a poorer prognosis than B-precursor ALL, as T-ALL patients exhibit 5-event free survival rates approximating 70-75% compared to > 90% for B-precursor-ALL. Notch1 activating mutations occur in more than 50% of T-ALL cases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::973c00beba8983ee438b98d18df23ff4
https://doi.org/10.1158/1538-7445.am2013-4116

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Abstract 2226: Mechanisms for cross-talk between Notch1 and AKT signaling in T-cell acute lymphoblastic leukemia

Autor: Larry H. Matherly, Eric C. Hales, Amanda Larson Gedman, Steven Orr, Jeffrey W. Taub

Publikováno v: Cancer Research. 72:2226-2226

Pediatric T-cell acute lymphoblastic leukemia (T-ALL) has a variable prognosis, with many patients exhibiting high-risk features at diagnosis, including older age and high presenting white blood cell counts. Activating mutations involving the Notch1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a905a6df58dff6988049a3c56c86c196
https://doi.org/10.1158/1538-7445.am2012-2226

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Abstract 2881: Posttranslational inactivation of PTEN promoted by loss of Notch1 signaling in T-ALL

Autor: Eric C. Hales, Amanda Larson Gedman, Larry H. Matherly, Jeffrey W. Taub, Yubin Ge

Publikováno v: Cancer Research. 71:2881-2881

T-cell acute lymphoblastic leukemias (T-ALL) are frequently associated with mutations in Notch 1, many of which lead to increased susceptibilities to cleavage by gamma secretase and generation of ICN1, promoting enhanced Notch1 signaling. Increased N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a25792a54e45e181df2e89566195cd01
https://doi.org/10.1158/1538-7445.am2011-2881

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