Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Eric C. Beyer"'
Autor:
Felipe Villanelo, Peter J. Minogue, Jaime Maripillán, Mauricio Reyna-Jeldes, Joaquin Jensen-Flores, Isaac E. García, Eric C. Beyer, Tomás Pérez-Acle, Viviana M. Berthoud, Agustín D. Martínez
Publikováno v:
Biological Research, Vol 57, Iss 1, Pp 1-18 (2024)
Abstract Background Members of the β-subfamily of connexins contain an intracellular pocket surrounded by amino acid residues from the four transmembrane helices. The presence of this pocket has not previously been investigated in members of the α-
Externí odkaz:
https://doaj.org/article/06defa631d704d8c9d7c419ba703475f
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
Our recent studies in mice suggest that a crucial event for the development of cataracts is the formation of calcium-containing deposits. To examine the generality of pathologic mineralization as a novel mechanism of cataract formation, we analyzed l
Externí odkaz:
https://doaj.org/article/d09b46ac46314a8cad6af590a282bd8e
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/3054744a84a143cf8ec1e8b2128f1124
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The lens is an avascular organ that is supported by an internal circulation of water and solutes. This circulation is driven by ion pumps, channels and transporters in epithelial cells and by ion channels in fiber cells and is maintained by fiber-fib
Externí odkaz:
https://doaj.org/article/d3b0dda7798c48c3a6d8d15ca8483ca6
Autor:
Peter J. Minogue, Andre J. Sommer, James C. Williams, Sharon B. Bledsoe, Eric C. Beyer, Viviana M. Berthoud
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Cataracts are lens opacities that are among the most common causes of blindness. It is commonly believed that cataracts develop through the accumulation of damage to lens proteins. However, recent evidence suggests that cataracts can result from calc
Externí odkaz:
https://doaj.org/article/2c33be56711345c4b7a6489b38d520f1
Publikováno v:
Cells, Vol 11, Iss 18, p 2786 (2022)
In the lens, cell homeostasis and transparency are supported by intercellular communication facilitated by the channels formed of connexin46 (Cx46) and connexin50 (Cx50). Mutations of these connexins are linked to inherited cataracts. We studied the
Externí odkaz:
https://doaj.org/article/2986c8a258fb4ad3ba71e640dba9eee8
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Endothelial damage is central to the pathogenesis of many of the complications of sickle cell disease. Circulating extracellular vesicles (EVs) have been implicated in modulating endothelial behavior in a variety of different, diseases with vascular
Externí odkaz:
https://doaj.org/article/0568afc5e87745379e073aaad6e75d26
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1418 (2020)
Cataracts of many different etiologies are associated with oxidation of lens components. The lens is protected by maintenance of a pool of reduced glutathione (GSH) and other antioxidants. Because gap junction channels made of the lens connexins, Cx4
Externí odkaz:
https://doaj.org/article/0aab8764106c40519d0a3c8a79230aa9
Autor:
Guoqiang Zhong, Nazem Akoum, Daniel A. Appadurai, Volodya Hayrapetyan, Osman Ahmed, Agustin D. Martinez, Eric C. Beyer, Alonso P. Moreno
Publikováno v:
Frontiers in Physiology, Vol 8 (2017)
In cardiac tissues, the expression of multiple connexins (Cx40, Cx43, Cx45, and Cx30.2) is a requirement for proper development and function. Gap junctions formed by these connexins have distinct permeability and gating mechanisms. Since a single cel
Externí odkaz:
https://doaj.org/article/92bbe9bcf95544a59704fc7268fe51c8
Autor:
Eric C. Beyer, Viviana M. Berthoud
Publikováno v:
F1000Research, Vol 6 (2017)
Gap junction channels facilitate the intercellular exchange of ions and small molecules, a process that is critical for the function of many different kinds of cells and tissues. Recent crystal structures of channels formed by one connexin isoform (c
Externí odkaz:
https://doaj.org/article/19e3f61803144536a7fcb2b079f3edde