Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Eric C Schirmer"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
Nuclear envelope transmembrane proteins (NETs) can reside in the outer or inner nuclear membrane, but distinguishing which membrane they reside in, and their translocation rate, is technically challenging. Here the authors develop a FRAP-based super-
Externí odkaz:
https://doaj.org/article/12654410bba34692906c4ecb63070f9b
Publikováno v:
Frontiers in Genetics, Vol 7 (2016)
It is well established that the nuclear envelope has many distinct direct connections to chromatin that contribute to genome organization. The functional consequences of genome organization on gene regulation are less clear. Even less understood is h
Externí odkaz:
https://doaj.org/article/1238363036504906bd2949c8bbf20fbf
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127712 (2015)
Recent work indicates that the nuclear envelope is a major signaling node for the cell that can influence tissue differentiation processes. Here we present two nuclear envelope trans-membrane proteins TMEM120A and TMEM120B that are paralogs encoded b
Externí odkaz:
https://doaj.org/article/e2e861eb9925477c807370bf129105d0
Autor:
Poonam Malik, Nikolaj Zuleger, Jose I de las Heras, Natalia Saiz-Ros, Alexandr A Makarov, Vassiliki Lazou, Peter Meinke, Martin Waterfall, David A Kelly, Eric C Schirmer
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111851 (2014)
Changes in the peripheral distribution and amount of condensed chromatin are observed in a number of diseases linked to mutations in the lamin A protein of the nuclear envelope. We postulated that lamin A interactions with nuclear envelope transmembr
Externí odkaz:
https://doaj.org/article/da7d495c934a4cabbed98c6922a14800
Autor:
Nadia Korfali, Vlastimil Srsen, Martin Waterfall, Dzmitry G Batrakou, Vanja Pekovic, Christopher J Hutchison, Eric C Schirmer
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18762 (2011)
Disruption of cell cycle regulation is one mechanism proposed for how nuclear envelope protein mutation can cause disease. Thus far only a few nuclear envelope proteins have been tested/found to affect cell cycle progression: to identify others, 39 n
Externí odkaz:
https://doaj.org/article/f2120497a649423292d49bd7e6f354b9
Autor:
Eric C. Schirmer
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/0f7032cc594c47a1a4b7b1e56e3094cb
Autor:
Eric C. Schirmer, Joanna M. Bridger
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/091feb11a2ce48baa5e6158d0e578db7
Autor:
Andrea Rizzotto, Sylvain Tollis, Nhan T. Pham, Yijing Zheng, Maria Alba Abad, Jan Wildenhain, A. Arockia Jeyaprakash, Manfred Auer, Mike Tyers, Eric C. Schirmer
Publikováno v:
Cells, Vol 13, Iss 1, p 57 (2023)
Increased nuclear size correlates with lower survival rates and higher grades for prostate cancer. The short-chain dehydrogenase/reductase (SDR) family member DHRS7 was suggested as a biomarker for use in prostate cancer grading because it is largely
Externí odkaz:
https://doaj.org/article/ac36edf31ab54a338b9f8da30a7b02e4
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Research on metastasis has recently regained considerable interest with the hope that single cell technologies might reveal the most critical changes that support tumor spread. However, it is possible that part of the answer has been visible through
Externí odkaz:
https://doaj.org/article/0ec24cf4e4994ef3bb95a4c10286d88d
Autor:
Charles R. Dixon, Poonam Malik, Jose I. de las Heras, Natalia Saiz-Ros, Flavia de Lima Alves, Mark Tingey, Eleanor Gaunt, A. Christine Richardson, David A. Kelly, Martin W. Goldberg, Greg J. Towers, Weidong Yang, Juri Rappsilber, Paul Digard, Eric C. Schirmer
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103055- (2021)
Summary: STimulator of INterferon Genes (STING) is an adaptor for cytoplasmic DNA sensing by cGAMP/cGAS that helps trigger innate immune responses (IIRs). Although STING is mostly localized in the ER, we find a separate inner nuclear membrane pool of
Externí odkaz:
https://doaj.org/article/7c77bb3feb48478187feaae2f2cec97e