Výsledky vyhledávání - "Eric C Griffith"

Akademický článek

A scalable platform for the development of cell-type-specific viral drivers

Autor: Sinisa Hrvatin, Christopher P Tzeng, M Aurel Nagy, Hume Stroud, Charalampia Koutsioumpa, Oren F Wilcox, Elena G Assad, Jonathan Green, Christopher D Harvey, Eric C Griffith, Michael E Greenberg

Publikováno v: eLife, Vol 8 (2019)

Enhancers are the primary DNA regulatory elements that confer cell type specificity of gene expression. Recent studies characterizing individual enhancers have revealed their potential to direct heterologous gene expression in a highly cell-type-spec

Externí odkaz: https://doaj.org/article/9e25154002544c1190234773b67776a3

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A NPAS4–NuA4 complex couples synaptic activity to DNA repair

Autor: Elizabeth A. Pollina, Daniel T. Gilliam, Andrew T. Landau, Cindy Lin, Naomi Pajarillo, Christopher P. Davis, David A. Harmin, Ee-Lynn Yap, Ian R. Vogel, Eric C. Griffith, M. Aurel Nagy, Emi Ling, Erin E. Duffy, Bernardo L. Sabatini, Charles J. Weitz, Michael E. Greenberg

Publikováno v: Nature. 614:732-741

Neuronal activity is crucial for adaptive circuit remodelling but poses an inherent risk to the stability of the genome across the long lifespan of postmitotic neurons1–5. Whether neurons have acquired specialized genome protection mechanisms that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f9ed43ab482915578c0efe328c0b468
https://doi.org/10.1038/s41586-023-05711-7

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Developmental dynamics of RNA translation in the human brain

Publikováno v: Nature neuroscience, vol 25, iss 10

The precise regulation of gene expression is fundamental to neurodevelopment, plasticity and cognitive function. Although several studies have profiled transcription in the developing human brain, there is a gap in understanding of accompanying trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f1812dea783a335dcb51a8256cbbf1
https://escholarship.org/uc/item/6gc2q79k

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Activity-dependent regulome of human GABAergic neurons reveals new patterns of gene regulation and neurological disease heritability

Autor: Eric C. Griffith, Jesse M. Engreitz, Gabriella L. Boulting, Michael R. Blanchard, Daniel Hochbaum, Ava C. Carter, David A. Harmin, Michael E. Greenberg, Maxwell A. Sherman, Adam J. Granger, Kevin Mei, Sinisa Hrvatin, Bulent Ataman, Marty G. Yang, Ershela Durresi

Publikováno v: Nature neuroscience

Neuronal activity-dependent gene expression is essential for brain development. Although transcriptional and epigenetic effects of neuronal activity have been explored in mice, such an investigation is lacking in humans. Because alterations in GABAer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a768f66e9dda312e76589792c9a152b
https://doi.org/10.1038/s41593-020-00786-1

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Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network

Autor: Cindy Lin, Onur Dagliyan, Christopher D. Harvey, Noah L. Pettit, David A. Harmin, Christopher P. Davis, Eric C. Griffith, Ee Lynn Yap, Emily Golden, M. Aurel Nagy, Michael E. Greenberg, Nikhil Sharma, Stephanie Rudolph

Publikováno v: Nature

Behavioural experiences activate the FOS transcription factor in sparse populations of neurons that are critical for encoding and recalling specific events1–3. However, there is limited understanding of the mechanisms by which experience drives cir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb20a216d24c67b70f8fb8fc5e5d4e96
https://doi.org/10.1038/s41586-020-3031-0

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Maternal immune activation in mice disrupts proteostasis in the fetal brain

Autor: Michael E. Greenberg, Yeong Shin Yim, Lilin Tong, Benjamin Finander, Erin E. Duffy, Hyunju Kim, Jun R. Huh, Gloria B. Choi, Eunha Kim, Casey K. Gilman, Randal J. Kaufman, Eric C. Griffith, Brian T. Kalish

Publikováno v: PMC
Nature neuroscience

© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. Maternal infection and inflammation during pregnancy are associated with neurodevelopmental disorders in offspring, but little is understood about the molecular mechanis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb394b5bcef6a7a33c99c4aa5945947
https://hdl.handle.net/1721.1/134109

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Neurons that regulate mouse torpor

Autor: Hanqi Yao, Sage Aronson, Elena G. Assad, Oren F Wilcox, Michaela E. Palmer, Alexander S. Banks, Senmiao Sun, Sinisa Hrvatin, Marcelo Cicconet, Eric C. Griffith, Michael E. Greenberg, Aurora J. Lavin-Peter

Publikováno v: Nature

The advent of endothermy, which is achieved through the continuous homeostatic regulation of body temperature and metabolism1,2, is a defining feature of mammalian and avian evolution. However, when challenged by food deprivation or harsh environment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c9d14c499023b563b4fffe7a810d63
https://pubmed.ncbi.nlm.nih.gov/32612215

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MeCP2 represses the rate of transcriptional initiation of highly methylated long genes

Autor: Benyam Kinde, Alexander W. Greben, Emmy Li, Hume Stroud, Andrew Silberfeld, Lisa D. Boxer, Tess Whitwam, Eric C. Griffith, Boyan B. Bonev, Michael E. Greenberg, Marty G. Yang, William Renthal

Publikováno v: Mol. Cell 77, 294-309.e9 (2020)
Mol Cell

Mutations in the methyl-DNA-binding repressor protein MeCP2 cause the devastating neurodevelopmental disorder Rett syndrome. It has been challenging to understand how MeCP2 regulates transcription because MeCP2 binds broadly across the genome, and Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3274932aec2be562569c83f8776db003
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=57858

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