Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Eric C Greene"'
Autor:
Jihyun Choi, Muwen Kong, Danielle N Gallagher, Kevin Li, Gabriel Bronk, Yiting Cao, Eric C Greene, James E Haber
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010056 (2022)
Using budding yeast, we have studied Rad51-dependent break-induced replication (BIR), where the invading 3' end of a site-specific double-strand break (DSB) and a donor template share 108 bp of homology that can be easily altered. BIR still occurs ab
Externí odkaz:
https://doaj.org/article/9b7086fc651b42c1a94cc5e31d1434a4
Autor:
Bryan Gibb, Ling F Ye, Stephanie C Gergoudis, YoungHo Kwon, Hengyao Niu, Patrick Sung, Eric C Greene
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87922 (2014)
Replication protein A (RPA) is a ubiquitous eukaryotic single-stranded DNA (ssDNA) binding protein necessary for all aspects of DNA metabolism involving an ssDNA intermediate, including DNA replication, repair, recombination, DNA damage response and
Externí odkaz:
https://doaj.org/article/8ad7a22fc0174f91a97b79220695b64a
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Srs2 is an Sf1a helicase that helps maintain genome stability in Saccharomyces cerevisiae through its ability to regulate homologous recombination. Srs2 downregulates HR by stripping Rad51 from single–stranded DNA, and Srs2 is also thought
Externí odkaz:
https://doaj.org/article/e92b342e61184bc08259e2881ed226a4
Autor:
Bryan Gibb, Eric C Greene
Publikováno v:
eLife, Vol 1 (2012)
Single-molecule imaging experiments have shed new light on the methods used by the enzyme RecA to align single- and double-stranded DNA so that double-strand breaks can be repaired.
Externí odkaz:
https://doaj.org/article/312d7a70a26b4e8fa3498aa917d80573
Autor:
Muwen Kong, Eric C. Greene
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
DNA double strand breaks (DSBs) are among some of the most deleterious forms of DNA damage. Left unrepaired, they are detrimental to genome stability, leading to high risk of cancer. Two major mechanisms are responsible for the repair of DSBs, homolo
Externí odkaz:
https://doaj.org/article/abc753da62a74618b4508711a51a7895
Dissociation of Rad51 Presynaptic Complexes and Heteroduplex DNA Joints by Tandem Assemblies of Srs2
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3166-3177 (2017)
Srs2 is a superfamily 1 (SF1) helicase and antirecombinase that is required for genome integrity. However, the mechanisms that regulate Srs2 remain poorly understood. Here, we visualize Srs2 as it acts upon single-stranded DNA (ssDNA) bound by the Ra
Externí odkaz:
https://doaj.org/article/a07f8631a2fb4ef5b5c35d232be50c04
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 988-998 (2016)
Cohesin is essential for the hierarchical organization of the eukaryotic genome and plays key roles in many aspects of chromosome biology. The conformation of cohesin bound to DNA remains poorly defined, leaving crucial gaps in our understanding of h
Externí odkaz:
https://doaj.org/article/cd39bc2c851e45709d2c7f69650044ab
Publikováno v:
Nucleic Acids Research
Mycobacterial AdnAB is a heterodimeric helicase-nuclease that initiates homologous recombination by resecting DNA double-strand breaks. The AdnB subunit hydrolyzes ATP to drive single-nucleotide steps of 3′-to-5′ translocation of AdnAB on the tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cc7dc46bcb61dc0c64ca9a5323de7e
http://europepmc.org/articles/PMC8789073
http://europepmc.org/articles/PMC8789073
Autor:
Eric C. Greene, Rodney Rothstein
Publikováno v:
Current Opinion in Genetics & Development. 71:iii-vii
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a14feef322308696c5e110ec1092085
https://doi.org/10.1016/j.gde.2021.10.003
https://doi.org/10.1016/j.gde.2021.10.003
Publikováno v:
Journal of Biological Chemistry. :104817
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b4d0a5c94bc0393e8f0fc18e8896a38
https://doi.org/10.1016/j.jbc.2023.104817
https://doi.org/10.1016/j.jbc.2023.104817