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Autor:
Rubin Jiang, Eric Brodean, Hao Chen, T. Craig Seamans, John Bowers, Kristin O'Neill, Sen Xu, Balrina Gupta, Linda Hoshan
Publikováno v:
Biotechnology Progress. 33:1146-1159
Bioreactor scale-up is a critical step in the production of therapeutic proteins such as monoclonal antibodies (MAbs). With the scale-up criterion such as similar power input per volume or O2 volumetric mass transfer coefficient ( kLa), adequate oxyg