Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Eric Brecht"'
Autor:
Hongxin Wang, Jiyong Zhao, Simon J. George, Wolfgang Sturhahn, Jay C. Nix, Stephen Keable, Yuming Xiao, Yisong Guo, E. Ercan Alp, Stephen P. Cramer, Eric Brecht, Michael W. W. Adams, Kristen Aznavour, Robert Bau, Francis E. Jenney, John W. Peters, Yoshitaka Yoda
Publikováno v:
Hyperfine Interactions. 222:77-90
We have applied 57Fe nuclear resonance vibrational spectroscopy (NRVS) for the first time to study the dynamics of Fe centers in Iron-sulfur protein crystals, including oxidized wild type rubredoxin crystals from Pyrococcus furiosus, and the MoFe pro
Autor:
Gergley Tóth, Hu Pan, Gary Probst, John-Michael Sauer, Dean R. Artis, Anh P. Truong, Michael P. Bova, Wes Zmolek, Ted Yednock, Jose Aquino, Michael S. Dappen, Kevin P. Quinn, Sukanto Sinha, Varghese John, Hing L. Sham, Michael A. Pleiss, Roy K. Hom, Lany Ruslim, Louis Brogley, Jennifer Sealy, Nanhua Yao, Larry Fang, Jay S. Tung, John A. Tucker, Eric Brecht, Andrei W. Konradi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4789-4794
Herein we describe further evolution of hydroxyethylamine inhibitors of BACE-1 with enhanced permeability characteristics necessary for CNS penetration. Variation at the P2' position of the inhibitor with more polar substituents led to compounds 19 a
Autor:
Hiro Tsuruta, Lance C. Seefeldt, Ranjana Sarma, Robert K. Szilagyi, David W. Mulder, John W. Peters, Eric Brecht
Publikováno v:
Biochemistry. 46:14058-14066
The MgATP-bound conformation of the Fe protein of nitrogenase from Azotobacter vinelandii has been examined in solution by small-angle X-ray scattering (SAXS) and compared to existing crystallographically characterized Fe protein conformations. The r
Autor:
Hing L. Sham, Ying-Zi Xu, Zhao Ren, Shendong Yuan, Julie Lougheed, Eric Brecht, Wayman Chan, Roy K. Hom, Lany Ruslim, Paul Beroza, Michael P. Bova, Dean R. Artis, Yong L. Zhu, Jiangli Yan, Simeon Bowers, Danny Tam, Hu Pan, Nanhua Yao
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(10)
Utilizing a structure based design approach, combined with extensive medicinal chemistry execution, highly selective, potent and novel BACE1 inhibitor 8 (BACE1 Alpha assay IC50=8nM) was made from a weak μM potency hit in an extremely efficient way.
Autor:
Gary Probst, Nanhua Yao, Danny Tam, Julie Lougheed, Zhao Ren, Hu Pan, Ying-Zi Xu, Wayman Chan, Dean R. Artis, Lany Ruslim, Shendong Yuan, Roy K. Hom, Yong L. Zhu, Paul Beroza, Andrei W. Konradi, Eric Brecht, Michael P. Bova, Hing L. Sham, Simeon Bowers
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(7)
The structure–activity relationship of a series of dihydroisoquinoline BACE-1 inhibitors is described. Application of structure-based design to screening hit 1 yielded sub-micromolar inhibitors. Replacement of the carboxylic acid of 1 was guided by
Autor:
Luc Desnoyers, Yuanhui Huang, Andrew Jang, Elizabeth Menendez, Jason Gary Sagert, Shouchun Liu, Eric Brecht, Olga Vasiljeva, Margaret Nguyen, Nicole Lapuyade, James W. West, Michael Krimm, Annie Yang Weaver, Jeanne Grace Flandez, Stephen R. Moore, Judi Ford, W. Michael Kavanaugh, Linnea Diep, Tereza Sputova, Jonathan A. Terrett, Shweta Singh, Amy DuPage, Jennifer Richardson
Publikováno v:
Molecular Cancer Therapeutics. 14:C165-C165
Antibody drug conjugates (ADCs) have shown their greatest clinical utility when targeting antigens expressed at very high levels on cancer cells that have coincidentally lower expression in normal tissues. This is exemplified by the approvals of tras
Autor:
Jay S. Tung, Nanhua Yao, Shawn Gauby, Kevin P. Quinn, May Lin, Lany Ruslim, Jennifer Sealy, Michael A. Pleiss, Luke Tso, John A. Tucker, Hu Pan, Gergely Toth, Sukanto Sinha, Andrei W. Konradi, Varghese John, Ying-Zi Xu, Anh P. Truong, Darren B. Dressen, Wes Zmolek, Gary Probst, Hing L. Sham, Eric Brecht, Jagodzinska Barbara, Jacek Jagodzinski, Michael P. Bova, Simeon Bowers, Roy K. Hom, John-Michael Sauer, Dean R. Artis, Brian P. Stupi, Ted Yednock, Andrea Gailunas, Jose Aquino
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(20)
The structure-activity relationship of the prime region of hydroxyethylamine BACE inhibitors is described. Variation in the aryl linker region with 5- and 6-membered heterocycles provided compounds such as 33 with improved permeability and reduced P-
Autor:
Oliver Kilian, Eric D. Becraft, Michael Kühl, John W. Peters, Arthur R. Grossman, Sheila Ingemann Jensen, Mary M. Bateson, David M. Ward, Eric Brecht, Anne-Soisig Steunou, Devaki Bhaya
Publikováno v:
The ISME journal. 2(4)
Nitrogen fixation, a prokaryotic, O2-inhibited process that reduces N2 gas to biomass, is of paramount importance in biogeochemical cycling of nitrogen. We analyzed the levels of nif transcripts of Synechococcus ecotypes, NifH subunit and nitrogenase
Autor:
David E. Schwab, John W. Peters, Robert K. Szilagyi, Eric Brecht, Cédric Tard, Christopher J. Pickett
Publikováno v:
Chemical communications (Cambridge, England). (35)
X-ray absorption spectroscopic measurements and density functional calculations suggest that the hydrogenase H-cluster is best described as an electronically inseparable 6Fe-cluster due to extensive delocalization of frontier molecular orbitals of th
Autor:
Michael Kühl, Anne-Soisig Steunou, Mary M. Bateson, John W. Peters, Melanie C. Melendrez, Eric Brecht, David M. Ward, Arthur R. Grossman, Devaki Bhaya
Genome sequences of two Synechococcus ecotypes inhabiting the Octopus Spring microbial mat in Yellowstone National Park revealed the presence of all genes required for nitrogenase biosynthesis. We demonstrate that nif genes of the Synechococcus ecoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9bff2b667ac0c77cf82b9eb486f42c
https://hdl.handle.net/10453/15344
https://hdl.handle.net/10453/15344