Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Eric Bortell"'
Autor:
Qingping Jiang, Bhumit Patel, Xin Jin, Deanna Di Grandi, Eric Bortell, Brooke Czapkowski, Thomas F. Lerch, Debra Meyer, Shruti Patel, Jodi Pegg, Alan Arbuckle, Julius Lagliva, Verl Sriskanda, Leo Letendre, Heyi Li, Elizabeth Thomas, Durgesh Nadkarni
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 6468-6475 (2019)
Externí odkaz:
https://doaj.org/article/8006d31914f840718224be2dbb3dfec2
Autor:
Shruti Patel, Julius Lagliva, Brooke Czapkowski, Xin Jin, Bhumit A. Patel, Verl Sriskanda, Alan Arbuckle, Eric Bortell, Pegg Jodi Ann, Durgesh V. Nadkarni, Leo Letendre, Debra M. Meyer, Heyi Li, Thomas F. Lerch, Deanna Di Grandi, Elizabeth Thomas, Qingping Jiang
Publikováno v:
ACS Omega, Vol 4, Iss 4, Pp 6468-6475 (2019)
The preparation of antibody drug conjugates (ADCs), particularly those containing hydrophobic payloads, may promote aggregate formation. The aggregate (high molecular mass species, HMMS) is an impurity that must be controlled in the final drug substa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e00ab32f41301c494eb6af23ae1b86d
https://doi.org/10.1021/acsomega.8b03627
https://doi.org/10.1021/acsomega.8b03627
Publikováno v:
Organic Process Research & Development. 21:601-610
As antibody drug conjugates (ADCs) move through clinical development, from phase 1 to pivotal studies, supported by clinical efficacy and appropriate safety, the development of late stage and commercial-ready processes and methods becomes a priority.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::569c164ce1514a49d79015e81bb92b54
https://doi.org/10.1021/acs.oprd.7b00023
https://doi.org/10.1021/acs.oprd.7b00023
Autor:
Sriram Srinivasan, Brad Evans, John Farley, Eric Bortell, Weiqiang Sun, Khurram Sunasara, Daniel Griffin, Michele Bailey Piatchek, Scott Cook, Katherine Arch-Douglas, John Cundy
Publikováno v:
Vaccine. 36(22)
The phrase "Process is the Product" is often applied to biologics, including multicomponent vaccines composed of complex components that evade complete characterization. Vaccine production processes must be defined and locked early in the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feae658bf780428c8c279d6fec6b6543
https://pubmed.ncbi.nlm.nih.gov/28433330
https://pubmed.ncbi.nlm.nih.gov/28433330
Autor:
Vicki Barniak, Dexiang Chen, John C. McMichael, Eric Bortell, Amy W. Masi, Karl R. VanDerMeid, Deb N. Chakravarti, Jeffrey D. Caplan
Publikováno v:
Vaccine. 18(1-2)
An outer membrane protein from Moraxella catarrhalis with a mass of 74-kDa was isolated and evaluated as a vaccine candidate. The 74-kDa protein binds transferrin, and appears to be related to the other proteins from the organism that are reported to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985ad89cc22ea84c225db3cb5b061368
https://pubmed.ncbi.nlm.nih.gov/10501241
https://pubmed.ncbi.nlm.nih.gov/10501241
Isolation and Characterization of Two Proteins from Moraxella catarrhalis That Bear a Common Epitope
Autor:
Jeffrey D. Caplan, Deb N. Chakravarti, Michael J. Fiske, Vicki Barniak, Eric Bortell, Dexiang Chen, Karl R. VanDerMeid, Steven M. Baker, Ross Fredenburg, John C. McMichael, Rasappa Arumugham
The UspA1 and UspA2 proteins of Moraxella catarrhalis are potential vaccine candidates for preventing disease caused by this organism. We have characterized both proteins and evaluated their vaccine potential using both in vitro and in vivo assays. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3c5c32d5f613bf141dada0e11c4533
https://europepmc.org/articles/PMC108528/
https://europepmc.org/articles/PMC108528/
Publikováno v:
Biotechnology progress. 14(1)
A recent advance in the state of the art of displacement chromatography has been the development of selective displacement chromatography. In this process, the bioproduct of interest is selectively displaced while impurities with lower retention are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9648aeb41a8c9d07b697b57fe9b89c
https://pubmed.ncbi.nlm.nih.gov/9496673
https://pubmed.ncbi.nlm.nih.gov/9496673