Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Eric Blair"'
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Cajal bodies (CBs) are major sub-nuclear structures in most eucaryotic cells. In human adenovirus 5 (Ad5) infection, CBs are reorganized into microfoci in the late phase of infection. Here we show that many CB protein components (p80-coilin,
Externí odkaz:
https://doaj.org/article/fba5d21e0f094aabb21460faa1457d28
Publikováno v:
Viruses, Vol 15, Iss 12, p 2311 (2023)
Nuclear bodies (NBs) are dynamic structures present in eukaryotic cell nuclei. They are not bounded by membranes and are often considered biomolecular condensates, defined structurally and functionally by the localisation of core components. Nuclear
Externí odkaz:
https://doaj.org/article/2268a2a19af4464b86f577b6a352d2e4
Autor:
Ethan L Morgan, Molly R Patterson, Emma L Ryder, Siu Yi Lee, Christopher W Wasson, Katherine L Harper, Yigen Li, Stephen Griffin, G Eric Blair, Adrian Whitehouse, Andrew Macdonald
Publikováno v:
PLoS Pathogens, Vol 16, Iss 6, p e1008624 (2020)
Human papillomaviruses (HPV) are a major cause of malignancy worldwide. They are the aetiological agents of almost all cervical cancers as well as a sub-set of other anogenital and head and neck cancers. Hijacking of host cellular pathways is essenti
Externí odkaz:
https://doaj.org/article/11bc911be97c4261b00c98e7510f9fc3
Autor:
Nnenna Nwogu, James R Boyne, Samuel J Dobson, Krzysztof Poterlowicz, G Eric Blair, Andrew Macdonald, Jamel Mankouri, Adrian Whitehouse
Publikováno v:
PLoS Pathogens, Vol 14, Iss 9, p e1007276 (2018)
Merkel cell carcinoma (MCC) is an aggressive skin cancer with a high propensity for recurrence and metastasis. Merkel cell polyomavirus (MCPyV) is recognised as the causative factor in the majority of MCC cases. The MCPyV small tumour antigen (ST) is
Externí odkaz:
https://doaj.org/article/4456a8d95da6401d8478db6c16dec394
Autor:
Özlem Cesur, Clare Nicol, Helen Groves, Jamel Mankouri, George Eric Blair, Nicola J. Stonehouse
Publikováno v:
Viruses, Vol 7, Iss 7, Pp 3443-3461 (2015)
Human papillomavirus (HPV) is the most common viral infection of the reproductive tract, affecting both men and women. High-risk oncogenic types are responsible for almost 90% of anogenital and oropharyngeal cancers including cervical cancer. Some of
Externí odkaz:
https://doaj.org/article/0fd62018c8924c9596f42c3331165ae0
Autor:
Tamara A. Belyaeva, Clare Nicol, Özlem Cesur, Gilles Travé, George Eric Blair, Nicola J. Stonehouse
Publikováno v:
Cancers, Vol 6, Iss 3, Pp 1553-1569 (2014)
Human papillomavirus 16 (HPV16) is a high-risk DNA tumour virus which is the primary causative agent of cervical cancer. Cell transformation arises from deregulated expression of the E6 and E7 oncogenes. E6 has been shown to bind a number of cellular
Externí odkaz:
https://doaj.org/article/7535139d317b4ebc87ae009c377dd3d3
Autor:
Frédéric Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT Human adenovirus (Ad) E1A proteins have long been known as the central regulators of virus infection as well as the major source of adenovirus oncogenic potential. Not only do they activate expression of other early viral genes, they make vi
Externí odkaz:
https://doaj.org/article/3384865bcf664ed09b505b5af535d394
Autor:
Frédéric Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT The human adenovirus E4orf6/E1B55K E3 ubiquitin ligase is well known to promote viral replication by degrading an increasing number of cellular proteins that inhibit the efficient production of viral progeny. We report here a new function of
Externí odkaz:
https://doaj.org/article/c01a38eed5be44cc8477ec767683e17f
Autor:
Clare Nicol, Özlem Cesur, Sophie Forrest, Tamara A Belyaeva, David H J Bunka, G Eric Blair, Nicola J Stonehouse
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64781 (2013)
BackgroundHuman papillomavirus 16 (HPV16) is a high-risk DNA tumour virus, which is a major causative agent of cervical cancer. Cellular transformation is associated with deregulated expression of the E6 and E7 oncogenes. E7 has been shown to bind a
Externí odkaz:
https://doaj.org/article/294d773af4774c22bff726cfb29127e1
Autor:
Siu Yi Lee, G. Eric Blair, Christopher W. Wasson, Molly R. Patterson, Yigen Li, Ethan L. Morgan, Andrew Macdonald, Katherine L. Harper, Adrian Whitehouse, Emma L. Ryder, Stephen Griffin
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 6, p e1008624 (2020)
PLoS Pathogens, Vol 16, Iss 6, p e1008624 (2020)
Human papillomaviruses (HPV) are a major cause of malignancy worldwide. They are the aetiological agents of almost all cervical cancers as well as a sub-set of other anogenital and head and neck cancers. Hijacking of host cellular pathways is essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f790f0f257673bcea947648c172db203
https://eprints.whiterose.ac.uk/161071/8/journal.ppat.1008624.pdf
https://eprints.whiterose.ac.uk/161071/8/journal.ppat.1008624.pdf