Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Eric Bertolino"'
Publikováno v:
Developmental Biology. 413:128-144
C/EBPα plays an instructive role in the macrophage-neutrophil cell-fate decision and its expression is necessary for neutrophil development. How Cebpa itself is regulated in the myeloid lineage is not known. We decoded the cis-regulatory logic of Ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998a2b3d03a9a15a6c1b9bd86bb8465c
https://doi.org/10.1016/j.ydbio.2016.02.030
https://doi.org/10.1016/j.ydbio.2016.02.030
Autor:
Eric Bertolino, Zhengshan Chen, Karen L. Reddy, Ignacio A. Demarco, Damien Reynaud, Stephen T. Smale, Susan Winandy, Harinder Singh, Hilde Schjerven
Publikováno v:
Nature Immunology. 9:927-936
The transcription factor Ikaros is essential for B cell development. However, its molecular functions in B cell fate specification and commitment have remained elusive. We show here that the transcription factor EBF restored the generation of CD19(+)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5e8c5de645708c8e70083fdeef6a95
https://doi.org/10.1038/ni.1626
https://doi.org/10.1038/ni.1626
Autor:
Thomas Treiber, Eric Bertolino, Daniel L. Northrup, Rudolf Grosschedl, Kay L. Medina, Matthew Thomas, David Allman, Jagan M. R. Pongubala, Harinder Singh, David W. Lancki
Publikováno v:
Nature Immunology
Alternative lineage restriction and B cell fate commitment require the transcription factor Pax5, but the function of early B cell factor (EBF) in these processes remains mostly unexplored. Here we show that in the absence of EBF, 'expandable' and cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b3dcfa2f54b90d46e77aeac3a95884a
https://doi.org/10.1038/ni1555
https://doi.org/10.1038/ni1555
Publikováno v:
Nature Immunology. 6:836-843
Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments has been suggested to be regulated by interleukin 7 signaling in pro-B cells. However, the genetic evidence for this recombination pathway has been challenged. Furthermore, no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc507e6e16d646e8d2a1b812f62fa16c
https://doi.org/10.1038/ni1226
https://doi.org/10.1038/ni1226
Autor:
Harinder Singh, Eric Bertolino
Publikováno v:
Molecular Cell. 10:397-407
Enhancers when functioning at a distance cannot effectively stimulate transcription from core promoters. We demonstrate that this is due to the inability of enhancer-bound activators to recruit TBP to a distal TATA box. Surprisingly, binding of a tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::819e594fad7ca90246d66f93af718d02
https://doi.org/10.1016/s1097-2765(02)00597-x
https://doi.org/10.1016/s1097-2765(02)00597-x
Publikováno v:
The EMBO Journal. 16:7105-7117
Oct-1 and Oct-2 represent the prototypical example of related transcription factors with identical DNA recognition properties. They bind functionally critical octamer elements found in diverse regulatory sequences. It has not been possible to determi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d7b5b288d45d2cfd99ce869d54bec6
https://doi.org/10.1093/emboj/16.23.7105
https://doi.org/10.1093/emboj/16.23.7105
Publikováno v:
Developmental Dynamics. 205:410-420
The TGIF homeobox gene encodes a homeoprotein that represses the 9-cis retinoic acid receptor-dependent transcription activation. To investigate the potential role of this gene in vertebrate development, we have isolated cDNA clones of the murine TGI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63713eec218558e85458225a401a709
https://doi.org/10.1002/(sici)1097-0177(199604)205:4<410::aid-aja5>3.0.co
https://doi.org/10.1002/(sici)1097-0177(199604)205:4<410::aid-aja5>3.0.co
Autor:
Joseph Triggs, Harinder Singh, Malay Mandal, Eric Bertolino, Mark Maienschein-Cline, Kyoko Ochiai, Aaron R. Dinner, Marcus R. Clark, Roger Sciammas
The molecular crosstalk between the interleukin 7 receptor (IL-7R) and the precursor to the B cell antigen receptor (pre-BCR) in B lymphopoiesis has not been elucidated. Here we demonstrate that in pre-B cells, the IL-7R but not the pre-BCR was coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f55fd706df0d721fae5746551e8041
https://europepmc.org/articles/PMC4028049/
https://europepmc.org/articles/PMC4028049/
Autor:
Peter Laslo, Yin C. Lin, Eric Bertolino, Harinder Singh, Sven Heinz, Nathanael J. Spann, Christopher K. Glass, Cornelis Murre, Christopher Benner, Jason X. Cheng
Publikováno v:
Molecular cell. 38(4)
Genome-scale studies have revealed extensive, cell type-specific colocalization of transcription factors, but the mechanisms underlying this phenomenon remain poorly understood. Here, we demonstrate in macrophages and B cells that collaborative inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2b5ebf09c94f208ef4499f89f42789
https://pubmed.ncbi.nlm.nih.gov/20513432
https://pubmed.ncbi.nlm.nih.gov/20513432
Autor:
Hilde Schjerven, Chauncey J. Spooner, Damien Reynaud, Karen L. Reddy, Harinder Singh, Stephen T. Smale, Eric Bertolino, Susan Winandy
Publikováno v:
The FASEB Journal. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1775ac8c494d19918b20fd8d8fc2be5
https://doi.org/10.1096/fasebj.22.1_supplement.844.7
https://doi.org/10.1096/fasebj.22.1_supplement.844.7