Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Eric Barklis"'
Autor:
Timothy A Bates, Mila Trank-Greene, Xammy Nguyenla, Aidan Anastas, Sintayehu K Gurmessa, Ilaria R Merutka, Shandee D Dixon, Anthony Shumate, Abigail R Groncki, Matthew AH Parson, Jessica R Ingram, Eric Barklis, John E Burke, Ujwal Shinde, Hidde L Ploegh, Fikadu G Tafesse
Publikováno v:
eLife, Vol 12 (2024)
Mycobacterium tuberculosis (Mtb) is known to survive within macrophages by compromising the integrity of the phagosomal compartment in which it resides. This activity primarily relies on the ESX-1 secretion system, predominantly involving the protein
Externí odkaz:
https://doaj.org/article/02546070fb4649659e3251bb6aab7254
Autor:
Jules B. Weinstein, Timothy A. Bates, Hans C. Leier, Savannah K. McBride, Eric Barklis, Fikadu G. Tafesse
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103960- (2022)
Summary: The spike glycoprotein of SARS-CoV-2 engages with human ACE 2 to facilitate infection. Here, we describe an alpaca-derived heavy chain antibody fragment (VHH), saRBD-1, that disrupts this interaction by competitively binding to the spike pro
Externí odkaz:
https://doaj.org/article/70a99d0c5b10463697388cb36e8ef93a
Autor:
Hans C. Leier, Jules B. Weinstein, Jennifer E. Kyle, Joon-Yong Lee, Lisa M. Bramer, Kelly G. Stratton, Douglas Kempthorne, Aaron R. Navratil, Endale G. Tafesse, Thorsten Hornemann, William B. Messer, Edward A. Dennis, Thomas O. Metz, Eric Barklis, Fikadu G. Tafesse
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Zika virus (ZIKV) remodels intracellular membranes for replication, but the role of different lipid types for infection and disease is unclear. Here, the authors perform lipidomics, show perturbation of the lipid network during ZIKV infection and sho
Externí odkaz:
https://doaj.org/article/e3700eeb09074ab692ee327211963128
Publikováno v:
Virology. 579:54-66
Trimers of the HIV-1 envelope (Env) protein perform receptor binding and virus-cell fusion functions during the virus life cycle. The cytoplasmic tail (CT) of Env forms an unusual baseplate structure, and is palmitoylated, rich in arginines, carries
Autor:
Ce Ann Romanaggi, Ayna Alfadhli, Robin Lid Barklis, Timothy A. Bates, Fikadu G. Tafesse, Ilaria Merutka, Eric Barklis
Publikováno v:
Virology
The capsid (CA) domain of the HIV-1 precursor Gag (PrGag) protein plays multiple roles in HIV-1 replication, and is central to the assembly of immature virions, and mature virus cores. CA proteins themselves are composed of N-terminal domains (NTDs)
Publikováno v:
Virology
Wild type (WT) HIV-1 envelope (Env) protein cytoplasmic tails (CTs) appear to be composed of membrane-proximal, N-terminal unstructured regions, and three C-terminal amphipathic helices. Previous studies have shown that WT and CT-deleted (ΔCT) Env p
Publikováno v:
J Mol Biol
Mutations of the Ras proteins HRAS, KRAS4A, KRAS4B, and NRAS are associated with a high percentage of all human cancers. The proteins are composed of highly homologous N-terminal catalytic or globular domains, plus C-terminal hypervariable regions (H
Autor:
Thomas O. Metz, Iris D. Zelnik, Lisa M. Bramer, Eric Barklis, R. Max Petty, Kent J. Bloodsworth, Jennifer E. Kyle, Ayna Alfadhli, Anthony H. Futerman, Robin Lid Barklis, Fikadu G. Tafesse, Hans C. Leier
Publikováno v:
The Journal of Biological Chemistry
The lipid composition of HIV-1 virions is enriched in sphingomyelin (SM), but the roles that SM or other sphingolipids (SLs) might play in the HIV-1 replication pathway have not been elucidated. In human cells, SL levels are regulated by ceramide syn
Autor:
Douglas Kempthorne, Jennifer E. Kyle, Kelly G. Stratton, Joon-Yong Lee, Edward A. Dennis, Thorsten Hornemann, Lisa M. Bramer, Jules B. Weinstein, Endale G. Tafesse, Eric Barklis, Aaron R. Navratil, Fikadu G. Tafesse, William B. Messer, Hans C. Leier, Thomas O. Metz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Zika virus (ZIKV), an arbovirus of global concern, remodels intracellular membranes to form replication sites. How ZIKV dysregulates lipid networks to allow this, and consequences for disease, is poorly understood. Here, we perform comprehensive lipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1f923f9d5dd4b4ac955dd9851ef4fc
https://doi.org/10.1101/2020.01.27.910919
https://doi.org/10.1101/2020.01.27.910919
Autor:
August O. Staubus, Ayna Alfadhli, Eric Barklis, Eric O. Freed, Philip R. Tedbury, Mariia Novikova
Publikováno v:
Journal of Virology. 93
The matrix (MA) domains of HIV-1 precursor Gag (PrGag) proteins direct PrGag proteins to plasma membrane (PM) assembly sites where envelope (Env) protein trimers are incorporated into virus particles. MA targeting to PM sites is facilitated by its bi