Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Eric Bareke"'
Autor:
Gerry A. Shipman, Reinnier Padilla, Cynthia Horth, Bo Hu, Eric Bareke, Francisca N. Vitorino, Joanna M. Gongora, Benjamin A. Garcia, Chao Lu, Jacek Majewski
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-28 (2024)
Abstract Background Methylation of histone 3 lysine 36 (H3K36me) has emerged as an essential epigenetic component for the faithful regulation of gene expression. Despite its importance in development and disease, how the molecular agents collectively
Externí odkaz:
https://doaj.org/article/452dd2d77ae044f69ef58363298ad192
Autor:
Elsa Brunet-Ratnasingham, Sacha Morin, Haley E. Randolph, Marjorie Labrecque, Justin Bélair, Raphaël Lima-Barbosa, Amélie Pagliuzza, Lorie Marchitto, Michael Hultström, Julia Niessl, Rose Cloutier, Alina M. Sreng Flores, Nathalie Brassard, Mehdi Benlarbi, Jérémie Prévost, Shilei Ding, Sai Priya Anand, Gérémy Sannier, Amanda Marks, Dick Wågsäter, Eric Bareke, Hugo Zeberg, Miklos Lipcsey, Robert Frithiof, Anders Larsson, Sirui Zhou, Tomoko Nakanishi, David Morrison, Dani Vezina, Catherine Bourassa, Gabrielle Gendron-Lepage, Halima Medjahed, Floriane Point, Jonathan Richard, Catherine Larochelle, Alexandre Prat, Janet L. Cunningham, Nathalie Arbour, Madeleine Durand, J. Brent Richards, Kevin Moon, Nicolas Chomont, Andrés Finzi, Martine Tétreault, Luis Barreiro, Guy Wolf, Daniel E. Kaufmann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized pat
Externí odkaz:
https://doaj.org/article/59f2aa4758444b718331711ce163fcf7
Autor:
Manqi Liang, Beena Suresh, Eric Bareke, Sanaa Choufani, Sujatha Jagadeesh, Rosanna Weksberg, Jacek Majewski, Rima Slim
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 12, Iss 2, Pp n/a-n/a (2024)
Abstract Background Recurrent miscarriage (RM) affects 1% to 5% of couples trying to conceive. Despite extensive clinical and laboratory testing, half of the RM cases remain unexplained. We report the genetic analysis of a couple with eight miscarria
Externí odkaz:
https://doaj.org/article/5643f311622043daa83507010d712958
Autor:
Audrey Labarre, Ericka Guitard, Gilles Tossing, Anik Forest, Eric Bareke, Marjorie Labrecque, Martine Tétreault, Matthieu Ruiz, J. Alex Parker
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-19 (2022)
A probiotic bacterial strain (Lacticaseibacillus rhamnosus) delays neurodegeneration phenotypes in C. elegans models of amyotrophic lateral sclerosis and Huntington’s disease, with fatty acid extracts from the bacteria able to reproduce the protect
Externí odkaz:
https://doaj.org/article/d4113e284c59414499856b89a89a1b1e
Autor:
Jean Mezreani, Sébastien Audet, Florence Martin, Jade Charbonneau, Valérie Triassi, Eric Bareke, Annie Laplante, Jason Karamchandani, Rami Massie, Colin H. Chalk, Erin O’Ferrall, Martine Tétreault
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-5 (2022)
Abstract Despite the growing accessibility of clinical sequencing, functional interpretation of variants remains a major hurdle to molecular diagnostics of Mendelian diseases. We aimed to describe a new adult-onset myopathy with muscle weakness and h
Externí odkaz:
https://doaj.org/article/755335b34f2a4c4abab5bcab98830aad
Autor:
Sabrina Shameen Alam, Shruti Kumar, Marie-Claude Beauchamp, Eric Bareke, Alexia Boucher, Nadine Nzirorera, Yanchen Dong, Reinnier Padilla, Si Jing Zhang, Jacek Majewski, Loydie A. Jerome-Majewska
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 6 (2022)
Heterozygous mutations in SNRPB, an essential core component of the five small ribonucleoprotein particles of the spliceosome, are responsible for cerebrocostomandibular syndrome (CCMS). We show that Snrpb heterozygous mouse embryos arrest shortly af
Externí odkaz:
https://doaj.org/article/1afd30dd48e1408eb3025a80778fcc3e
Autor:
Nargess Farhangdoost, Cynthia Horth, Bo Hu, Eric Bareke, Xiao Chen, Yinglu Li, Mariel Coradin, Benjamin A. Garcia, Chao Lu, Jacek Majewski
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108769- (2021)
Summary: Chromatin dysregulation has emerged as an important mechanism of oncogenesis. To develop targeted treatments, it is important to understand the transcriptomic consequences of mutations in chromatin modifier genes. Recently, mutations in the
Externí odkaz:
https://doaj.org/article/fdfe19949dae4154a4bffa104cdbb0ba
Autor:
Ashot S. Harutyunyan, Haifen Chen, Tianyuan Lu, Cynthia Horth, Hamid Nikbakht, Brian Krug, Caterina Russo, Eric Bareke, Dylan M. Marchione, Mariel Coradin, Benjamin A. Garcia, Nada Jabado, Jacek Majewski
Publikováno v:
Cell Reports, Vol 33, Iss 7, Pp 108390- (2020)
Summary: The discovery of H3K27M mutations in pediatric gliomas marked a new chapter in cancer epigenomics. Numerous studies have investigated the effect of this mutation on H3K27 trimethylation, but only recently have we started to realize its addit
Externí odkaz:
https://doaj.org/article/ad26cd7d47e94a5684d71e175b0b6da1
Autor:
Carolina Cavalieri Gomes, Tenzin Gayden, Andrea Bajic, Osama F. Harraz, Jonathan Pratt, Hamid Nikbakht, Eric Bareke, Marina Gonçalves Diniz, Wagner Henriques Castro, Pascal St-Onge, Daniel Sinnett, HyeRim Han, Barbara Rivera, Leonie G. Mikael, Nicolas De Jay, Claudia L. Kleinman, Elvis Terci Valera, Angelia V. Bassenden, Albert M. Berghuis, Jacek Majewski, Mark T. Nelson, Ricardo Santiago Gomez, Nada Jabado
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Giant cell lesions of the jaw (GCLJ) are debilitating benign tumors of unclear origin. The authors identify driver recurrent somatic mutations in TRPV4, KRAS and FGFR1 and show they converge on aberrant activation of the MAPK pathway. Their findings
Externí odkaz:
https://doaj.org/article/e7587955769c46cb9c57d9d348d2db3d
Autor:
Sophie Depiereux, Bertrand De Meulder, Eric Bareke, Fabrice Berger, Florence Le Gac, Eric Depiereux, Patrick Kestemont
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0128598 (2015)
Sex steroids play a key role in triggering sex differentiation in fish, the use of exogenous hormone treatment leading to partial or complete sex reversal. This phenomenon has attracted attention since the discovery that even low environmental doses
Externí odkaz:
https://doaj.org/article/ab289c593d1848eb9dad25e9c152effb