Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Eric Ailor"'
Autor:
Jesus Velasco, Robert W. Cross, Rebekah M. James, Galit Alter, Kartik Chandran, Niaz Rahim, Dafna M. Abelson, John M. Dye, Andrew S. Herbert, Kevin J. Whaley, Xiangguo Qiu, Michael H. Pauly, Shihua He, Do H. Kim, Logan Banadyga, Natasha Bohorova, Kevin Tierney, Viktoriya Borisevich, Anna Z. Wec, Eric Ailor, Laura M. Walker, Joan B. Geisbert, Eileen C. Goodwin, Chad E. Mire, Bronwyn M. Gunn, Wenjun Zhu, Ognian Bohorov, Thomas W. Geisbert, Zachary A. Bornholdt, William S. Shestowsky, Krystle N. Agans, Larry Zeitlin
All available experimental vaccines and immunotherapeutics1,2 against Ebola virus (EBOV), including rVSV-ZEBOV3 and ZMappTM4, lack activity against other ebolaviruses associated with human disease outbreaks. This year, two separate outbreaks of EBOV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c61c819d381e3e9deb68c869a4089e0
https://doi.org/10.1101/395533
https://doi.org/10.1101/395533
Autor:
Laura M. Walker, Shihua He, Logan Banadyga, Thomas W. Geisbert, Joan B. Geisbert, Galit Alter, Kartik Chandran, Natasha Bohorova, Xiangguo Qiu, Viktoriya Borisevich, Dafna M. Abelson, Rebekah M. James, Ariel S. Wirchnianski, Do H. Kim, Niaz Rahim, Bronwyn M. Gunn, Jesus Velasco, Wenjun Zhu, Andrew S. Herbert, Kevin J. Whaley, Robert W. Cross, Anna Z. Wec, Chad E. Mire, Ognian Bohorov, Kevin Tierney, Zachary A. Bornholdt, Michael H. Pauly, Eric Ailor, Eileen C. Goodwin, William S. Shestowsky, Larry Zeitlin, Krystle N. Agans, John M. Dye
Publikováno v:
Cell Host & Microbe. 25:49-58.e5
Summary Recent and ongoing outbreaks of Ebola virus disease (EVD) underscore the unpredictable nature of ebolavirus reemergence and the urgent need for antiviral treatments. Unfortunately, available experimental vaccines and immunotherapeutics are sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c3f7cc53f9285ce82687183e77b15f0
https://doi.org/10.1016/j.chom.2018.12.005
https://doi.org/10.1016/j.chom.2018.12.005
Autor:
Weixing Yang, Eric Ailor, Flora Huang, Michelle C. Vendel, Jennifer L. Gardner, Dorre A. Grueneberg, Edward J Richards, Stephen Demarest, Xiangyang Tan, Suzanne Szak, Louise A. Koopman, Adam Doern, Wilson O. Endege, Ed Harlow
Publikováno v:
Biochemistry. 52:3102-3118
Tyro3, a member of the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases, has emerged as a potential oncogene in melanoma. Here, we confirm that Tyro3 is specifically overexpressed in primary melanoma samples and show that Tyro3 is expressed at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea93669302efe97ec10911b99651e9b1
https://doi.org/10.1021/bi301588c
https://doi.org/10.1021/bi301588c
Autor:
Kandasamy Hariharan, Melissa Levesque, Angelina Altshuler, William B. Snyder, Christopher L. Reyes, Eric Ailor, Michael Favis, Hon Tran, Flora Huang, Rachel Rennard, Steffan Ho, Michael Shields, Stephen Demarest, Tracey Murphy, C Hession, David Gregson, Scott Glaser, Albert Flavier, Lisa Berquist, Xianjun Cao, Adam Doern, Tracey Snipas, William S. Shestowsky, Susan Tamraz, Xiufeng Wu, Jianying Dong, Ellen Garber, Mitchell Reff, Christilyn Graff, Arlene Sereno, Lindsay J. Cole
Publikováno v:
Journal of Biological Chemistry. 284:10254-10267
Therapeutic antibodies directed against the type 1 insulin-like growth factor receptor (IGF-1R) have recently gained significant momentum in the clinic because of preliminary data generated in human patients with cancer. These antibodies inhibit liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::370bee5e80e2a7da845a4c3a5501533c
https://doi.org/10.1074/jbc.m809709200
https://doi.org/10.1074/jbc.m809709200
Autor:
J. Marie Hardwick, Douglas Osborne, Bruno Figueroa, Eric Ailor, Michael J. Betenbaugh, Mitchell Reff
Publikováno v:
Biotechnology and Bioengineering. 97:877-892
Mammalian cells are used for the production of numerous biologics including monoclonal antibodies. Unfortunately, mammalian cells can lose viability at later stages in the cell culture process. In this study, the effects of expressing the anti-apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d91c9d92a1c4175ad94c9171ad1eb6e
https://doi.org/10.1002/bit.21222
https://doi.org/10.1002/bit.21222
Autor:
Katsuyoshi Masuda, Eric Ailor, Donald L. Jarvis, Noriko Takahashi, Badarulhisam Abdul Rahman, Michael J. Betenbaugh, Yuan C. Lee, Yoshinori Tsukamoto
Publikováno v:
Glycobiology. 10:837-847
The N-glycans of human serum transferrin produced in Trichopulsia ni cells were analyzed to examine N-linked oligosaccharide processing in insect cells. Metabolic radiolabeling of the intra- and extracellular protein fractions revealed the presence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92ca23b20acea2da7410fee53157d90d
https://doi.org/10.1093/glycob/10.8.837
https://doi.org/10.1093/glycob/10.8.837
Autor:
Michael J. Betenbaugh, Eric Ailor
Publikováno v:
Biotechnology and Bioengineering. 58:196-203
The secretion of heterologous IgG proteins in the baculovirus-insect cell expression system is accompanied by substantial insoluble immunoglobulin in the infected cells. The accumulation of these insoluble forms suggests a limitation in the processin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ed905bc22cd867bd6c9a56af5f13bed
https://doi.org/10.1002/(sici)1097-0290(19980420)58:2/3<196::aid-bit12>3.0.co
https://doi.org/10.1002/(sici)1097-0290(19980420)58:2/3<196::aid-bit12>3.0.co
Publikováno v:
Cytotechnology. 20(1-3)
The BEVS has become widely utilized for production of recombinant proteins. However, protein aggregation and inefficient processing often limit yields, especially for secreted and membrane proteins. Since many proteins of pharmaceutical interest requ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba39739f0f7fc495bb3ae9cf229c36e8
https://pubmed.ncbi.nlm.nih.gov/22358480
https://pubmed.ncbi.nlm.nih.gov/22358480
Publikováno v:
ESACT Proceedings ISBN: 1402027915
Mammalian cell culture is widely used for the production of therapeutic proteins and for the generation of cells for cell and gene therapies. During cell culture, these cells can be exposed to a number of external and internal insults including nutri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fae943177970b24a4b2b355c0ab32f1
https://doi.org/10.1007/1-4020-3103-3_7
https://doi.org/10.1007/1-4020-3103-3_7