Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Eric A. Toth"'
Autor:
Matthew C. Metcalf, Benjamin M. Janus, Rui Yin, Ruixue Wang, Johnathan D. Guest, Edwin Pozharski, Mansun Law, Roy A. Mariuzza, Eric A. Toth, Brian G. Pierce, Thomas R. Fuerst, Gilad Ofek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Hepatitis C virus (HCV) is a major global health burden as the leading causative agent of chronic liver disease and hepatocellular carcinoma. While the main antigenic target for HCV-neutralizing antibodies is the membrane-associated E1E2 sur
Externí odkaz:
https://doaj.org/article/5c8f3813e8b4474bb3fa9ada06482823
Autor:
Brian G. Pierce, Nathaniel Felbinger, Matthew Metcalf, Eric A. Toth, Gilad Ofek, Thomas R. Fuerst
Publikováno v:
Viruses, Vol 16, Iss 5, p 803 (2024)
Hepatitis C virus (HCV) is a major medical health burden and the leading cause of chronic liver disease and cancer worldwide. More than 58 million people are chronically infected with HCV, with 1.5 million new infections occurring each year. An effec
Externí odkaz:
https://doaj.org/article/af9cc06e950b41f584ef5b3cb302dc5d
Autor:
Yingwei Chen, Eric A. Toth, Biao Ruan, Eun Jung Choi, Richard Simmerman, Yihong Chen, Yanan He, Ruixue Wang, Raquel Godoy-Ruiz, Harlan King, Gregory Custer, D. Travis Gallagher, David A. Rozak, Melani Solomon, Silvia Muro, David J. Weber, John Orban, Thomas R. Fuerst, Philip N. Bryan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Chen et al. describe a rational design of subtilisin mutants that degrade active RAS by cleaving a conserved sequence in switch 2. They further modified the active site to be dependent on a cofactor to generate high target specificity. Proteases engi
Externí odkaz:
https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6
Autor:
Andrey Romanyuk, Ruixue Wang, Alexander Marin, Benjamin M. Janus, Eric I. Felner, Dengning Xia, Yenny Goez-Gazi, Kendra J. Alfson, Abdul S. Yunus, Eric A. Toth, Gilad Ofek, Ricardo Carrion, Mark R. Prausnitz, Thomas R. Fuerst, Alexander K. Andrianov
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 1, p 16 (2022)
Ebolavirus (EBOV) infection in humans is a severe and often fatal disease, which demands effective interventional strategies for its prevention and treatment. The available vaccines, which are authorized under exceptional circumstances, use viral vec
Externí odkaz:
https://doaj.org/article/a885540978ff4542aea23a7fac2aa739
Publikováno v:
Viruses, Vol 13, Iss 6, p 1027 (2021)
An effective vaccine for the hepatitis C virus (HCV) is a major unmet medical and public health need, and it requires an antigen that elicits immune responses to multiple key conserved epitopes. Decades of research have generated a number of vaccine
Externí odkaz:
https://doaj.org/article/15f70596146a4edd86604c3d60c91b4c
Autor:
Kevin Mauge-Lewis, Brittney Gordon, Fareeha Syed, Saarah Syed, Enock Bonyi, Muzaffer Mohammed, Eric A. Toth, Dereje Seifu, Kadir Aslan
Publikováno v:
Nano Biomedicine and Engineering, Vol 8, Iss 2, Pp 60-71 (2016)
The effect of metal surfaces on the crystallization of lysozyme using the Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique and a monomode microwave system is described. Our microwave system (is called the iCrys
Externí odkaz:
https://doaj.org/article/adf1495c225d494ab49169994d04e1db
Autor:
Rena G. Lapidus, Brandon A. Carter-Cooper, Mariola Sadowska, Eun Yong Choi, Omasiri Wonodi, Nidal Muvarak, Karthika Natarajan, Lakshmi S. Pidugu, Anil Jaiswal, Eric A. Toth, Feyruz V. Rassool, Arash Etemadi, Edward A. Sausville, Maria R. Baer, Ashkan Emadi
Publikováno v:
Pharmaceuticals, Vol 9, Iss 1, p 4 (2016)
Selective targeting of the oxidative state, which is a tightly balanced fundamental cellular property, is an attractive strategy for developing novel anti-leukemic chemotherapeutics with potential applications in the treatment of acute myeloid leukem
Externí odkaz:
https://doaj.org/article/9e1d3d412caa48ea961cdee4faf734f5
Autor:
Frances Rocamora, Angelo G Peralta, Seunghyeon Shin, James Sorrentino, Mina Wu, Eric A Toth, Thomas R Fuerst, Nathan E Lewis
Over recent decades, therapeutic proteins have had widespread success in treating a myriad of diseases. Glycosylation, a near universal feature of this class of drugs, is a critical quality attribute that significantly influences the physical propert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2b87fec95f855bab48b07427add325
https://doi.org/10.20944/preprints202303.0072.v1
https://doi.org/10.20944/preprints202303.0072.v1
Autor:
Eric M Toth, MD Minhaz Chowdhury
Publikováno v:
2022 IEEE World AI IoT Congress (AIIoT).
Autor:
John Orban, Yihong Chen, Yanan He, David J. Weber, Eun Jung Choi, Raquel Godoy-Ruiz, Biao Ruan, D. Travis Gallagher, Melani Solomon, Thomas R. Fuerst, Ruixue Wang, David A. Rozak, Gregory S. Custer, Philip N. Bryan, Harlan King, Silvia Muro, Eric A. Toth, Yingwei Chen, Richard Simmerman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
We describe the design, kinetic properties, and structures of engineered subtilisin proteases that degrade the active form of RAS by cleaving a conserved sequence in switch 2. RAS is a signaling protein that, when mutated, drives a third of human can