Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Eric A. Standley"'
Autor:
Mihaela M. Esanu, Edmund Leung, Nande Wright, Selcuk Calimsiz, Xiang Wang, Olivier St-Jean, Eric A. Standley, Guojun Yu, Li Wang, Dustin Bringley, Roberts Benjamin James, Jaspal Phull, Anna Chiu, Jason A. Davy, Doxsee Ian James, Jeffrey D. Ng, Wen-Tau T. Chang, Lennie Lin, Jenny Phoenix, David Allen Siler, Olga Lapina, Andrea Ambrosi, Youri Kim, Jeffrey A. O. Garber, Jinyu Shen, Bernard Kwong, Keshab Sarma, Bing Shi, Andrew Anthony Martins
Publikováno v:
Organic Process Research & Development. 25:1215-1236
This manuscript describes the chemical process development and multi-kilogram synthesis of rovafovir etalafenamide (GS-9131), a phosphonamidate prodrug nucleotide reverse transcriptase inhibitor un...
Autor:
Jeffrey A. O. Garber, Edmund Leung, Olga Lapina, Selcuk Calimsiz, Keshab Sarma, Jonah W. Curl, Guojun Yu, Andrew Anthony Martins, Bing Shi, Jaspal Phull, Bernard Kwong, Jinyu Shen, Andrea Ambrosi, Sankar Mohan, Mary Rosario, Huy V. Huynh, Li Wang, Lennie Lin, Dustin Bringley, Eric A. Standley, Teague M. McGinitie, Xueqing Wang, Ben Roberts
Publikováno v:
Organic Process Research & Development. 25:1247-1262
Phosphonamidate 1 is a key fragment in the assembly of rovafovir etalafenamide, a novel nucleotide reverse transcriptase inhibitor under development at Gilead Sciences for the treatment of HIV infe...
Autor:
Frank Glorius, J. Luca Schwarz, Eric A. Standley, Karin Gottschalk, Sabrina Bernard, Elodie Decuypere, Michael Teders, Davide Audisio, Constantin G. Daniliuc, Frédéric Taran
Publikováno v:
Organic letters. 21(23)
Herein we report on the development of an MS tag screening strategy that accelerates the discovery of photocatalytic reactions. By efficiently combining mechanism- and reaction-based screening dimensions, the respective advantages of each strategy we
Publikováno v:
Chemistry - A European Journal. 22:9971-9974
Herein is reported the catalytic, visible light-promoted, decarboxylative halogenation (bromination, chlorination, and iodination) of aliphatic carboxylic acids. This operationally-simple reaction tolerates a range of functional groups, proceeds at r
Autor:
Mark D. Simon, Alexander A. Vinogradov, Eric A. Standley, Zi-Ning Choo, Zachary P. Gates, Sarah Z. Tasker, Anthony J. Quartararo, Evan D. Styduhar, Faycal Touti, Kathryn H. Halloran, Jessica Laura Wilson, Surin K. Mong, Alexander J. Mijalis, Anupam Bandyopadhyay, Jessica M. Weber, Timothy F. Jamison, Ethan D. Evans, Bradley L. Pentelute
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Significance Combinatorial protein libraries—prepared via molecular biology-based approaches—are invaluable tools for protein engineering. The inclusion of noncanonical amino acids in such libraries is of considerable interest. However, at presen
Publikováno v:
Journal of the American Chemical Society. 136:11145-11152
Herein, we report the first ligand-controlled, nickel-catalyzed cross-coupling of aliphatic N-tosylaziridines with aliphatic organozinc reagents. The reaction protocol displays complete regioselectivity for reaction at the less hindered C-N bond, and
Publikováno v:
Organometallics
A series of air-stable nickel complexes of the form L2Ni(aryl) X (L = monodentate phosphine, X = Cl, Br) and LNi(aryl)X (L = bis-phosphine) have been synthesized and are presented as a library of precatalysts suitable for a wide variety of nickel-cat
Publikováno v:
ChemInform. 47
Herein is reported the catalytic, visible light-promoted, decarboxylative halogenation (bromination, chlorination, and iodination) of aliphatic carboxylic acids. This operationally-simple reaction tolerates a range of functional groups, proceeds at r
Autor:
Benjamin L. Ingalls, Sylvanna V. Krawczyk, Eric C. Brown, Benjamin F. Gherman, Nicholas G. Spiropulos, Eric A. Standley, Ian R. Shaw, Bryan Diebels, Atta M. Arif
Publikováno v:
Inorganica Chimica Acta. 386:83-92
Treatment of Zn(II) and Cd(II) hydroxide complexes of the tris(2-pyridylmethyl)amine (TPA) ligand with COS or CS2 in protic solvents (MeOH or EtOH) resulted in [(TPA)Zn–SC(S)OCH3]ClO4 (1), [(TPA)Zn– SC(O)OCH3]BF4 (2), [(TPA)Zn–SC(O)OCH3]ClO4 (3