Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Eric A. Sigel"'
Autor:
Denes Haase, John W. Cuozzo, John Barker, Pia Thommes, Michael Zahn, Avery Hunt, Vasileios Roumpelakis, Ying Zhang, Emily Trimby, Elise Gadouleau, Alain Dorali, Kostas Papadopoulos, Ole A. Andersen, Christoph E. Dumelin, Christel Compper, Michelle Southey, Christopher Lumley, Eric A. Sigel, Paolo A. Centrella, Barbara Mertins, Maisie Holbrow-Wilshaw, Spencer Napier, Adele Faulkner, Magali Dejob, Timothy Gorman, Alastair L Parkes, Boudewijn Dejonge, Thomas Krulle, Ricky Cain, Jennifer Williams, Boer Deng, Olivier Barbeau, Anthony D. Keefe, Sian Evans, David F. Corbett, Donnya Etheridge, Daniel B. Stein, Ryan M Dominic, Dawn M. Troast, Xianfu Li, Rajesh Odedra, Matthew A. Clark, Anthony P Dickie, Holly T Soutter, Kate Spear, Angelo Sanzone
Publikováno v:
Journal of Medicinal Chemistry. 64:14377-14425
This study describes a novel series of UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitors that was identified through affinity-mediated selection from a DNA-encoded compound library. The original hit was a selective inhibitor of Pseudomonas ae
Publikováno v:
Clinical Pediatrics. :000992282211469
The goal of this project was to determine whether screening youth and parents for firearm presence and imbedding those results in the electronic medical record (EMR) increased health care provider (HCP) documentation of firearms and subsequent delive
Autor:
M Dominic, Ryan, Alastair L, Parkes, David, Corbett, Anthony P, Dickie, Michelle, Southey, Ole A, Andersen, Daniel B, Stein, Olivier R, Barbeau, Angelo, Sanzone, Pia, Thommes, John, Barker, Ricky, Cain, Christel, Compper, Magali, Dejob, Alain, Dorali, Donnya, Etheridge, Sian, Evans, Adele, Faulkner, Elise, Gadouleau, Timothy, Gorman, Denes, Haase, Maisie, Holbrow-Wilshaw, Thomas, Krulle, Xianfu, Li, Christopher, Lumley, Barbara, Mertins, Spencer, Napier, Rajesh, Odedra, Kostas, Papadopoulos, Vasileios, Roumpelakis, Kate, Spear, Emily, Trimby, Jennifer, Williams, Michael, Zahn, Anthony D, Keefe, Ying, Zhang, Holly T, Soutter, Paolo A, Centrella, Matthew A, Clark, John W, Cuozzo, Christoph E, Dumelin, Boer, Deng, Avery, Hunt, Eric A, Sigel, Dawn M, Troast, Boudewijn L M, DeJonge
Publikováno v:
Journal of medicinal chemistry. 64(19)
This study describes a novel series of UDP
Autor:
Matthew A. Clark, Xie Zhifeng, Ying Zhang, Daniel I. Resnicow, Louis Renzetti, Heather A. Thomson, Frank Ruebsam, John W. Cuozzo, Mark Mulvihill, Eric A. Sigel, Anna Kohlmann, Wang Ce, Anthony D. Keefe, Ni Haihong
Publikováno v:
Journal of medicinal chemistry. 63(14)
The activity of the secreted phosphodiesterase autotaxin produces the inflammatory signaling molecule LPA and has been associated with a number of human diseases including idiopathic pulmonary fibrosis (IPF). We screened a single DNA-encoded chemical
Autor:
Xia Tian, Patrick Riley, Diana Gikunju, Ying Zhang, Christopher D. Hupp, Ling Xue, Matthew A. Clark, Betty Chan, Steven Kearnes, Christelle Huguet, Anthony D. Keefe, Dennis Joseph Moccia, John P. Guilinger, Marie-Aude Guié, Christopher James Mulhern, Kevin McCloskey, John W. Cuozzo, Sana Bazzaz, Eric A. Sigel
Publikováno v:
Journal of medicinal chemistry. 63(16)
DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein targets of therapeutic value through screening of libraries with up to billions of unique small molecules. We demonstrate a new approach
Autor:
Eric A. Sigel, Paolo A. Centrella, Ying Zhang, Stefan Geschwindner, Niek Dekker, Sevan Habeshian, Matthew A. Clark, Cédric Fiez-Vandal, Dawn M. Troast, John W. Cuozzo, Marie-Aude Guié, Linda Sundström, Christoph E. Dumelin, Giselle R. Wiggin, Jing Zhang, Robert M. Cooke, Kaan Certel, Dean G. Brown, Arjan Snijder, Giles A. Brown, Anthony D. Keefe, Oliver Schlenker, Andrew D. Ferguson, Holly T Soutter
Publikováno v:
SLAS Discovery. 23:429-436
The discovery of ligands via affinity-mediated selection of DNA-encoded chemical libraries is driven by the quality and concentration of the protein target. G-protein-coupled receptors (GPCRs) and other membrane-bound targets can be difficult to isol
Autor:
Holly H. Soutter, Matthew A. Clark, Sevan Habeshian, Eric A. Sigel, Paolo A. Centrella, Diana Gikunju, Christopher D. Hupp, John W. Cuozzo, Anthony D. Keefe, Ying Zhang, Heather A. Thomson
Publikováno v:
ChemBioChem. 18:864-871
We have identified and characterized novel potent inhibitors of Bruton's tyrosine kinase (BTK) from a single DNA-encoded library of over 110 million compounds by using multiple parallel selection conditions, including variation in target concentratio
Autor:
Martin J. Packer, David J. Hargreaves, Xiaolan Zheng, Nancy Su, Haiye Lan, Carl Beigie, Christoph E. Dumelin, Matthew A. Belmonte, Chengyan Wu, Hao Ma, Dawn M. Troast, Haidong Shen, Anthony D. Keefe, Ying Zhang, Kate F. Wickson, Philip B. Rawlins, Yunxia Li, John W. Cuozzo, Steven L. Kazmirski, Michelle Lamb, Eric A. Sigel, Paolo A. Centrella, Matthew A. Clark, Camil Joubran, Haiyun Wang, Scott Mlynarski, Shenggen Cao, Stephanie M. Bates, Holly H. Soutter, Qiuying Zhao, Daniel W. Robbins, Jeffrey W. Johannes, Sevan Habeshian, John Breen, Andrew D. Ferguson, Alexander Hird
Publikováno v:
ACS Medicinal Chemistry Letters. 8:239-244
Mcl-1 is a pro-apoptotic BH3 protein family member similar to Bcl-2 and Bcl-xL. Overexpression of Mcl-1 is often seen in various tumors and allows cancer cells to evade apoptosis. Here we report the discovery and optimization of a series of non-natur
Autor:
John W. Cuozzo, Paolo A. Centrella, Diana Gikunju, Sevan Habeshian, Christopher D. Hupp, Anthony D. Keefe, Eric A. Sigel, Holly H. Soutter, Heather A. Thomson, Ying Zhang, Matthew A. Clark
Publikováno v:
Chembiochem : a European journal of chemical biology. 18(24)
Autor:
Haiye Lan, Sevan Habeshian, Yunxia Li, Ying Zhang, Matthew A. Belmonte, Philip B. Rawlins, Chengyan Wu, Daniel W. Robbins, John Breen, Christoph E. Dumelin, Holly H. Soutter, Martin J. Packer, Carl Beigie, Nancy Su, David J. Hargreaves, Xiaolan Zheng, Scott Mlynarski, Stephanie M. Bates, Steven L. Kazmirski, Michelle Lamb, Matthew A. Clark, Dawn M. Troast, Shenggen Cao, Haiyun Wang, Qiuying Zhao, Jeffrey W. Johannes, John W. Cuozzo, Kate F. Wickson, Eric A. Sigel, Paolo A. Centrella, Camil Joubran, Hao Ma, Haidong Shen, Anthony D. Keefe, Alexander Hird, Andrew D. Ferguson
Publikováno v:
ACS medicinal chemistry letters. 8(11)
Mcl-1 is a pro-apoptotic BH3 protein family member similar to Bcl-2 and Bcl-xL. Overexpression of Mcl-1 is often seen in various tumors and allows cancer cells to evade apoptosis. Here we report the discovery and optimization of a series of non-natur