A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology

Autor: Eric A. Hungate, Sapana R. Vora, Eric R. Gamazon, Takaya Moriyama, Timothy Best, Imge Hulur, Younghee Lee, Tiffany-Jane Evans, Eva Ellinghaus, Martin Stanulla, Jéremie Rudant, Laurent Orsi, Jacqueline Clavel, Elizabeth Milne, Rodney J. Scott, Ching-Hon Pui, Nancy J. Cox, Mignon L. Loh, Jun J. Yang, Andrew D. Skol, Kenan Onel

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)

A risk variant located at 9p21.3 is associated with cancer risk in pediatric B-cell precursor acute lymphoblastic leukaemia. Here, the authors show that this variant affects the gene expression of the tumour suppressor gene Cdkn2b.

Externí odkaz: https://doaj.org/article/3b8c31642c1f4f19aeefef51e4219d06

Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Autor: Anne M. Dickinson, Gail Jones, David C. Linch, Clare Lendrem, David Grimwade, Richard A. Larson, Andrew D. Skol, Yaobo Xu, Adam Ivey, Wei-Yu Lin, Manja Meggendorfer, Rosemary E. Gale, Inés Gómez-Seguí, Giovani Marconi, Jean Norden, Jude Fitzgibbon, Mette K. Andersen, M Bornhäuser, Sarah E. Fordham, Amanda F. Gilkes, Heinz Sill, Eric A. Hungate, José Cervera, Friedrich Stölzel, Julia Gaal-Wesinger, Kim Piechocki, Wendy Stock, Theresa Hahn, Konstantin Strauch, David Allsup, Kenan Onel, Claire Elstob, Alyssa I. Clay-Gilmour, Nicola J. Sunter, Jelena D. Milosevic Feenstra, Meyling Cheok, Abrar Alharbi, Ann K. Daly, Sally Jeffries, Lisa Wagenführ, Olaf Heidenreich, Robert Kralovics, Alan K. Burnett, Giovanni Martinelli, Desiree Kunadt, Christian Gieger, Francesco Lo-Coco, Leo Ruhnke, Maria Teresa Voso, Junke Wang, Catherine Park, Nigel H. Russell, Chimène Moreilhon, Robert Kerrin Hills, Claude Preudhomme, Graham Jackson, Daniel Nowak, Maria Chiara Fontana, James M. Allan, Heidi Altmann, Richard S. Houlston, Anne S. Quante, Michelle M. Le Beau, Thahira Rahman, Christoph Röllig, Rebecca Darlay, Sophie Raynaud, Helen Marr, Csaba Bödör, Louise Palm, Thomas Cluzeau, Szilvia Krizsán, Heather J. Cordell, Mathew Collin, Torsten Haferlach, Lara E. Sucheston-Campbell, Wolf-Karsten Hofmann, Kimmo Porkka, Andras Masszi, Hervé Dombret, Miguel A. Sanz, Elisabeth Douglas, Tobias Menne

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nat. Commun. 12:6233 (2021)
Nature Communications

Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 104

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66da5a2f677e98ca34ff7ab5930a5dd3
http://hdl.handle.net/10138/337099

Neuroblastoma survivors are at increased risk for second malignancies: A report from the International Neuroblastoma Risk Group Project

Autor: Mark A. Applebaum, Sharon J. Diskin, Wendy B. London, Eric A. Hungate, Julie R. Park, Arlene Naranjo, Navin Pinto, Samuel L. Volchenboum, Susan L. Cohn, Barbara E. Stranger, Barbara Hero, Andrew D.J. Pearson, Zalman Vaksman, Tara O. Henderson, Sang Mee Lee

Publikováno v: European Journal of Cancer. 72:177-185

Background: The incidence of second malignant neoplasm (SMN) within the first ten years of diagnosis in high-risk neuroblastoma patients treated with modern, intensive therapy is unknown. Further, the underlying germline genetics that contribute to S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cbf626ec00c1e9e8b6cc8427f781eb8
https://doi.org/10.1016/j.ejca.2016.11.022

The Rising Incidence of Second Cancers: Patterns of Occurrence and Identification of Risk Factors for Children and Adults

Autor: Gregory T. Armstrong, Rochelle E. Curtis, Lindsay M. Morton, Kenan Onel, Eric A. Hungate

Publikováno v: American Society of Clinical Oncology Educational Book. :e57-e67

As the population of cancer survivors has increased and continues to age, the occurrence of second cancers has risen dramatically—from 9% of all cancer diagnoses in 1975–1979 to 19% in 2005–2009. The Childhood Cancer Survivor Study, a cohort of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99715ad5eb8f0daca90310a3ea5ea44c
https://doi.org/10.14694/edbook_am.2014.34.e57

A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology

Autor: Imge Hulur, Laurent Orsi, Eric R. Gamazon, Jérémie Rudant, Mignon L. Loh, Eva Ellinghaus, Eric A. Hungate, Ching-Hon Pui, Martin Stanulla, Andrew D. Skol, Timothy Best, Sapana Vora, Takaya Moriyama, Elizabeth Milne, Younghee Lee, Tiffany-Jane Evans, Jacqueline Clavel, Rodney J. Scott, Nancy J. Cox, Kenan Onel, Jun J. Yang

Publikováno v: Nature communications, vol 7, iss 1
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Nature Communications
Nature communications, 7. Nature Publishing Group

Paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) is the most common cancer of childhood, yet little is known about BCP-ALL predisposition. In this study, in 2,187 cases of European ancestry and 5,543 controls, we discover and repli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc4ac6c5fcd21c7c8e03cb61d0f52ce
https://doi.org/10.1038/ncomms10635