Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Eric A. Huebner"'
Autor:
Rotem Ben-Tov Perry, Ida Rishal, Ella Doron-Mandel, Ashley L. Kalinski, Katalin F. Medzihradszky, Marco Terenzio, Stefanie Alber, Sandip Koley, Albina Lin, Meir Rozenbaum, Dmitry Yudin, Pabitra K. Sahoo, Cynthia Gomes, Vera Shinder, Wasim Geraisy, Eric A. Huebner, Clifford J. Woolf, Avraham Yaron, Alma L. Burlingame, Jeffery L. Twiss, Mike Fainzilber
Publikováno v:
Cell Reports, Vol 16, Iss 6, Pp 1664-1676 (2016)
How can cells sense their own size to coordinate biosynthesis and metabolism with their growth needs? We recently proposed a motor-dependent bidirectional transport mechanism for axon length and cell size sensing, but the nature of the motor-transpor
Externí odkaz:
https://doaj.org/article/fc300a54f86641f7bb4eff5b310e8bd0
Autor:
Alban Latremoliere, Long Cheng, Michelle DeLisle, Chen Wu, Sheena Chew, Elizabeth B. Hutchinson, Andrew Sheridan, Chloe Alexandre, Frederic Latremoliere, Shu-Hsien Sheu, Sara Golidy, Takao Omura, Eric A. Huebner, Yanjie Fan, Mary C. Whitman, Elaine Nguyen, Crystal Hermawan, Carlo Pierpaoli, Max A. Tischfield, Clifford J. Woolf, Elizabeth C. Engle
Publikováno v:
Cell Reports, Vol 24, Iss 7, Pp 1865-1879.e9 (2018)
Summary: We generated a knockout mouse for the neuronal-specific β-tubulin isoform Tubb3 to investigate its role in nervous system formation and maintenance. Tubb3−/− mice have no detectable neurobehavioral or neuropathological deficits, and upr
Externí odkaz:
https://doaj.org/article/39973573a0814e0c95602d286adca792
Autor:
Tammy Szu-Yu Ho, Eric A. Huebner, Nick Andrews, Luis M. Pereira, Takao Omura, Lee Barrett, Stephen M. Strittmatter, Zhaoxin Jiang, Clifford J. Woolf, Stephane Budel, Bhagat Singh, Janie Merkel, Michael Costigan, Kush Kapur, Xingxing Wang
Publikováno v:
Mol Neurobiol
Axotomy results in permanent loss of function after brain and spinal cord injuries due to the minimal regenerative propensity of the adult central nervous system (CNS). To identify pharmacological enhancers of axon regeneration, 960 compounds were sc
Autor:
Lee L. Rubin, Clifford J. Woolf, Bjoern Schwer, Frederick W. Alt, Devlin Frost, Riki Kawaguchi, Jelena Ivanis, Priscilla Riva, Yung-Chih Cheng, Lance S. Davidow, Michael Costigan, Anthony C. Arvanites, Alyssa Grantham, Andrew Snavely, Eric A. Huebner, Rie Maeda, Ivan Tochitsky, Crystal Herman, Vatsal Oza, Xuefei Zhang, Giovanni Coppola, Bhagat Singh, Lee Barrett, Q. Wang, Kathleen L. Pfaff, Amelia N. Chang, Miyuki Sakuma
Publikováno v:
Cell Reports. 36:109666
Although axonal damage induces rapid changes in gene expression in primary sensory neurons, it remains unclear how this process is initiated. The transcription factor ATF3, one of the earliest genes responding to nerve injury, regulates expression of
Autor:
Marco Terenzio, Vera Shinder, Ida Rishal, Stefanie Alber, Dmitry Yudin, Ella Doron-Mandel, Pabitra K. Sahoo, Clifford J. Woolf, Alma L. Burlingame, Avraham Yaron, Cynthia Gomes, Meir Rozenbaum, Albina Lin, Sandip Koley, Mike Fainzilber, Rotem Ben-Tov Perry, Ashley L. Kalinski, Wasim Geraisy, Katalin F. Medzihradszky, Jeffery L. Twiss, Eric A. Huebner
Publikováno v:
Cell Reports
Cell Reports, Vol 16, Iss 6, Pp 1664-1676 (2016)
Cell Reports, Vol 16, Iss 6, Pp 1664-1676 (2016)
Summary How can cells sense their own size to coordinate biosynthesis and metabolism with their growth needs? We recently proposed a motor-dependent bidirectional transport mechanism for axon length and cell size sensing, but the nature of the motor-
Autor:
Lee Barrett, Peter Langfelder, Zhigang He, Giovanni Coppola, Jeremy Davis-Turak, Armin Blesch, Takao Omura, Michael Costigan, Vijayendran Chandran, Izhak Michaelevski, Mike Fainzilber, Clifford J. Woolf, Homaira Nawabi, Revital Versano, Eric A. Huebner, Ajay S. Yekkirala, Daniel H. Geschwind, Fuying Gao, Alice Zhang, Larry I. Benowitz, Steve Horvath, Mark H. Tuszynski
Publikováno v:
Neuron, vol 89, iss 5
Summary The regenerative capacity of the injured CNS in adult mammals is severely limited, yet axons in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury. We reasoned that coordinate regulation of gene expression in
Autor:
Larry I. Benowitz, Joshua S. Martin, Stella J. Lee, Clifford J. Woolf, S. Thomas Carmichael, Michio W. Painter, Kumiko Omura, Véronique Lisi, Bhagat Singh, Andrea Tedeschi, Kenneth S. Kosik, Giovanni Coppola, Zhigang He, Alban Latremoliere, Daniel H. Geschwind, Kush Kapur, Priscilla Riva, Songlin Li, Fuying Gao, Yuqin Yin, Tom Crisman, Takao Omura, Eric A. Huebner, Leticia Rojas, Michael Costigan, Lee Barrett
Publikováno v:
Omura, T; Omura, K; Tedeschi, A; Riva, P; Painter, MW; Rojas, L; et al.(2015). Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron, 86(5), 1215-1227. doi: 10.1016/j.neuron.2015.05.005. UCLA: Retrieved from: http://www.escholarship.org/uc/item/17d6z0rz
Neuron, vol 86, iss 5
Neuron, vol 90, iss 3
Neuron
Neuron, vol 86, iss 5
Neuron, vol 90, iss 3
Neuron
© 2015 Elsevier Inc. Axon regeneration in the CNS requires reactivating injured neurons' intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dors
Autor:
Wardiya Afshar Saber, Amy J. Wang, Lee L. Rubin, Kush Kapur, Christian Brenneis, Clifford J. Woolf, Kevin Eggan, Lee Barrett, Júlia Teixeira Oliveira, Seungkyu Lee, Canan Bilgin, Naomi Tsujimoto, Cassidy Mellin, Isaac M. Chiu, Justin K. Ichida, Elizabeth D. Buttermore, Eric A. Huebner, Brian J. Wainger
Publikováno v:
Nature neuroscience
Reprogramming somatic cells from one cell fate to another can generate specific neurons suitable for disease modeling. To maximize the utility of patient-derived neurons, they must model not only disease-relevant cell classes, but also the diversity
Autor:
Véronique Lisi, Clifford J. Woolf, Elmer Guzman, Yung-Chih Cheng, Michael Costigan, Michio W. Painter, Bhagat Singh, Kenneth S. Kosik, Eric A. Huebner, Giovanni Coppola, Michel Giroux
Publikováno v:
Cell reports, vol 20, iss 5
Lisi, V; Singh, B; Giroux, M; Guzman, E; Painter, MW; Cheng, Y-C; et al.(2017). Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury. CELL REPORTS, 20(5), 1136-1147. doi: 10.1016/j.celrep.2017.07.010. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/98n0q06r
Cell Reports, Vol 20, Iss 5, Pp 1136-1147 (2017)
Lisi, V; Singh, B; Giroux, M; Guzman, E; Painter, MW; Cheng, Y-C; et al.(2017). Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury. CELL REPORTS, 20(5), 1136-1147. doi: 10.1016/j.celrep.2017.07.010. UC Santa Barbara: Retrieved from: http://www.escholarship.org/uc/item/98n0q06r
Cell Reports, Vol 20, Iss 5, Pp 1136-1147 (2017)
Summary: Peripheral nerve regeneration after injury requires a broad program of transcriptional changes. We investigated the basis for the enhanced nerve regenerative capacity of the CAST/Ei mouse strain relative to C57BL/6 mice. RNA sequencing of do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315e509b47018f8f7cdd9f2f5af548fa
Autor:
Clifford J. Woolf, Sheena Chew, Max A. Tischfield, Shu Hsien Sheu, Sara Golidy, Alban Latremoliere, Long Cheng, Elaine Nguyen, Elizabeth C. Engle, Chen Wu, Yanjie Fan, Elizabeth B. Hutchinson, Takao Omura, Mary C. Whitman, Chloe Alexandre, Frederic Latremoliere, Eric A. Huebner, Andrew Sheridan, Crystal Hermawan, Michelle M. DeLisle, Carlo Pierpaoli
Publikováno v:
Cell Reports, Vol 24, Iss 7, Pp 1865-1879.e9 (2018)
Summary: We generated a knockout mouse for the neuronal-specific β-tubulin isoform Tubb3 to investigate its role in nervous system formation and maintenance. Tubb3−/− mice have no detectable neurobehavioral or neuropathological deficits, and upr