Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Eric A. Horne"'
Autor:
Nephi Stella, Linda Wordeman, Denny Liggitt, Rodney J.Y. Ho, John D. Scott, Juan Jesus Vicente, Barry Rickman, Eric A. Horne, Jonathan Coy, David A. Canton, Jennifer Freeling, Michael Wagenbach, Katie Swinney, Cong Xu, Susan Fung, Alipi V. Naydenov, Brian R. Haas, Allison E. Cherry
Figure S1: Representative histological features of orthotropic DBT tumor 3 weeks after implantation Figure S2: Semi-quantitative analysis of microglial invasion of DBT tumors Figure S3: ST-11 reduces proliferation and triggers apoptosis in DBT cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3997f3f2ee600e57080d05a17f49ca
https://doi.org/10.1158/1535-7163.22504173.v1
https://doi.org/10.1158/1535-7163.22504173.v1
Autor:
Nephi Stella, Linda Wordeman, Denny Liggitt, Rodney J.Y. Ho, John D. Scott, Juan Jesus Vicente, Barry Rickman, Eric A. Horne, Jonathan Coy, David A. Canton, Jennifer Freeling, Michael Wagenbach, Katie Swinney, Cong Xu, Susan Fung, Alipi V. Naydenov, Brian R. Haas, Allison E. Cherry
T98G cell transfected with GFP-EB3 (green) to label growing MT tips and RFP-CenpB (red) to label centromeres. Speed = 10Ã-.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31002cf893c043e9dab6cebdc897e248
https://doi.org/10.1158/1535-7163.22504179
https://doi.org/10.1158/1535-7163.22504179
Autor:
Eric A. Horne, Patrick J. Cimino, Eric C. Holland, N. Wageling, Debra K. Kumasaka, Linda Wordeman, Daniel D Azorín, Ernest Hamel, Cong Xu, Michael Wagenbach, Philippe Diaz, Frank Winkler, Nephi Stella, Erik Jung
Publikováno v:
Neuro-oncology Advances
BackgroundGlioma is sensitive to microtubule-targeting agents (MTAs), but most MTAs do not cross the blood brain barrier (BBB). To address this limitation, we developed the new chemical entity, ST-401, a brain-penetrant MTA.MethodsSynthesis of ST-401
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1bfc145b0391ed89f1823a0578d8834
https://doi.org/10.1093/noajnl/vdaa165
https://doi.org/10.1093/noajnl/vdaa165
Autor:
Michael Wagenbach, Erik Jung, Eric A. Horne, Eric C. Holland, Cong Xu, Juan Ruiz, Frank Winkler, Ernest Hamel, Linda Wordeman, Philippe Diaz, Nephi Stella, Patrick J. Cimino, Debra K. Kumasaka
Publikováno v:
Neuro Oncol
Most cancer therapeutics developed to date are excluded from the brain and are therefore ineffective in treating glioma, the most devastating type of brain cancer in adults. Microtubule targeting agents (MTAs) are indispensable medicines to treat a w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b07f46801883bf4dca8218851d65f44
https://europepmc.org/articles/PMC7650914/
https://europepmc.org/articles/PMC7650914/
Autor:
Eric A. Horne, Ernest Hamel, Philippe Diaz, Mike Wagenbach, Hothi Parvinder, Cong Xu, Ravil R. Petrov, Brian Hass, Rick Gussio, Linda Wordeman, Nephi Stella
Small molecules that target microtubules (MTs) represent promising therapeutics to treat certain types of cancer, including glioblastoma multiform (GBM). We synthesized modified carbazoles and evaluated their antitumor activity in GBM cells in cultur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3e26c2bf8b02a24851ab9c18be2171f
https://europepmc.org/articles/PMC6216603/
https://europepmc.org/articles/PMC6216603/
Autor:
Eric A. Horne, Heather O'Leary, Mark L. Dell'Acqua, Holly R. Robertson, K. Ulrich Bayer, Steven J. Coultrap, Kevin M. Woolfrey, Dayton J. Goodell
Publikováno v:
The Journal of biological chemistry. 293(5)
Both long-term potentiation (LTP) and depression (LTD) of excitatory synapse strength require the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) and its autonomous activity generated by Thr-286 autophosphorylation. Additionally, LTP and L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113151304b4628eb2616093d044cb0b5
https://pubmed.ncbi.nlm.nih.gov/29196604
https://pubmed.ncbi.nlm.nih.gov/29196604
Autor:
Michael Wagenbach, Philippe Diaz, Patrick J. Cimino, Juan-Jesus Vicente, Ernest Hamel, Linda Wordeman, Nephi Stella, Rick Gussio, Eric A. Horne, Thomas Deckwerth, Cong Xu, Eric C. Holland, Benjamin Uhlenbruck
Publikováno v:
Neuro Oncol
Glioblastomas are particularly sensitive to mitotic disruption when compared with nonmalignant cells and thus microtubule-targeting agents (MTA) represent promising therapeutics to treat patients with glioblastomas; but few such compounds pass the bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a8af72cf425cc5ae6d0b4276bd1422
https://doi.org/10.1093/neuonc/noz175.280
https://doi.org/10.1093/neuonc/noz175.280
Autor:
Rodney J. Y. Ho, Susan Fung, Michael Wagenbach, Eric A. Horne, Barry Rickman, Allison E. Cherry, John D. Scott, Linda Wordeman, Juan Jesus Vicente, Cong Xu, Jonathan Coy, Brian Haas, Nephi Stella, Denny Liggitt, Alipi Naydenov, David A. Canton, Katie Swinney, Jennifer P. Freeling
Glioblastoma multiforme is a devastating and intractable type of cancer. Current antineoplastic drugs do not improve the median survival of patients diagnosed with glioblastoma multiforme beyond 14 to 15 months, in part because the blood–brain barr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25df3e4058f502d70f6c84e40c571a07
https://europepmc.org/articles/PMC5010991/
https://europepmc.org/articles/PMC5010991/
Autor:
Susan Fung, Ken Mackie, Grace Woodruff, Eric A. Horne, Ágnes L. Bodor, Jacqueline L. Blankman, Jessica P. Alexander, Thomas Möller, Nephi Stella, Jonathan Coy, Aurore Thomazeau, Weiwei Li, Sherry Shu Jung Hu, Olivier J. Manzoni, Benjamin F. Cravatt, Giulio G. Muccioli, William R. Marrs, Yi Hsing Lin, Jonathan Z. Long, Mathieu Lafourcade, Cong Xu
Publikováno v:
Nature Neuroscience, Vol. 13, no. 8, p. 951-7 (2010)
Nature Neuroscience
Nature Neuroscience, 2010, 13 (8), pp.951-957. ⟨10.1038/nn.2601⟩
Nature Neuroscience
Nature Neuroscience, 2010, 13 (8), pp.951-957. ⟨10.1038/nn.2601⟩
International audience; The endocannabinoid 2-arachidonoylglycerol (2-AG) regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. Enzymes that hydrolyze 2-AG, su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57535df1cdec0bb8ed0906959b18e96
https://doi.org/10.1038/nn.2601
https://doi.org/10.1038/nn.2601
Autor:
Eric A. Horne, Vicente Martinez, Jeremy Clark, Paul E. M. Phillips, Stefan G. Sandberg, Ingo Willuhn, Andrew S. Hart, Christina A. Akers, Nephi Stella, Jones Griffith Parker, Matthew J. Wanat, Jerylin O. Gan, Scott B. Evans
Publikováno v:
Nature methods
Neurotransmission operates on a millisecond timescale, but is changed by normal experience or neuropathology over days, weeks or even months. Despite the great importance of long-term neurotransmitter dynamics, no technique exists to track these chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96369f1baa3de21730e6f02810a4492
https://doi.org/10.1038/nmeth.1412
https://doi.org/10.1038/nmeth.1412