SAPS3 subunit of protein phosphatase 6 is an AMPK inhibitor and controls metabolic homeostasis upon dietary challenge in male mice

Autor: Ying Yang, Michael A. Reid, Eric A. Hanse, Haiqing Li, Yuanding Li, Bryan I. Ruiz, Qi Fan, Mei Kong

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Inhibition of AMPK leads to metabolic perturbations yet how AMPK is inactivated is not fully understood. Here the authors show protein phosphatase 6 subunit SAPS3 is a negative regulator of AMPK and loss of SAPS3 activates AMPK and protects male mice

Externí odkaz: https://doaj.org/article/8f7ad0483fc24007b0f8a6180e5a79ba

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

Autor: Mari B. Ishak Gabra, Ying Yang, Haiqing Li, Parijat Senapati, Eric A. Hanse, Xazmin H. Lowman, Thai Q. Tran, Lishi Zhang, Linda T. Doan, Xiangdong Xu, Dustin E. Schones, David A. Fruman, Mei Kong

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

The availability of nutrients within the tumour microenvironment can influence tumour growth. Here, the authors find that, in a melanoma mouse model, mice fed a high glutamine diet have reduced tumour growth, increased sensitivity to Braf inhibitors

Externí odkaz: https://doaj.org/article/f55f7d0478ab4cf7851235354cd349ce

p53 Promotes Cancer Cell Adaptation to Glutamine Deprivation by Upregulating Slc7a3 to Increase Arginine Uptake

Autor: Xazmin H. Lowman, Eric A. Hanse, Ying Yang, Mari B. Ishak Gabra, Thai Q. Tran, Haiqing Li, Mei Kong

Publikováno v: Cell Reports, Vol 26, Iss 11, Pp 3051-3060.e4 (2019)

Summary: Cancer cells heavily depend on the amino acid glutamine to meet the demands associated with growth and proliferation. Due to the rapid consumption of glutamine, cancer cells frequently undergo glutamine starvation in vivo. We and others have

Externí odkaz: https://doaj.org/article/436fe2b531ba49b3a816c5598a9e6dd7

Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth

Autor: Dustin E. Schones, Linda Doan, Xazmin H. Lowman, Mari B. Ishak Gabra, Haiqing Li, Eric A. Hanse, Xiangdong Xu, David A. Fruman, Lishi Zhang, Ying Yang, Mei Kong, Thai Q. Tran, Parijat Senapati

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications

Tumour cells adapt to nutrient deprivation in vivo, yet strategies targeting the nutrient poor microenvironment remain unexplored. In melanoma, tumour cells often experience low glutamine levels, which promote cell dedifferentiation. Here, we show th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf4cf82621dc0c7d4e73de1f6629b584
https://doaj.org/article/f55f7d0478ab4cf7851235354cd349ce

MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1

Autor: Juan Liu, Ying Yang, Xazmin H. Lowman, Ziv Gil, Jason W. Locasale, Eric A. Hanse, Michael A. Reid, Mei Kong, Thai Q. Tran, Mari B. Ishak Gabra, Haiqing Li, Neta Milman

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Yang, Ying; Ishak Gabra, Mari B; Hanse, Eric A; Lowman, Xazmin H; Tran, Thai Q; Li, Haiqing; et al.(2019). MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1.. Nature communications, 10(1), 809. doi: 10.1038/s41467-019-08759-0. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/88p6h77m

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers. It thrives in a nutrient-poor environment; however, the mechanisms by which PDAC cells undergo metabolic reprogramming to adapt to metabolic stress are still poorly unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2363638684d49b7411237adaf70619f3
https://doaj.org/article/a9fee3fb145c4ef5be976c2f1bd995e7