Výsledky vyhledávání - "Eric A. G. Blomme"

Akademický článek

Preclinical species gene expression database: Development and meta-analysis

Autor: Caitlin Krause, Kinga Suwada, Eric A. G. Blomme, Kenneth Kowalkowski, Michael J. Liguori, Prathap Kumar Mahalingaiah, Scott Mittelstadt, Richard Peterson, Lauren Rendino, Andy Vo, Terry R. Van Vleet

Publikováno v: Frontiers in Genetics, Vol 13 (2023)

The evaluation of toxicity in preclinical species is important for identifying potential safety liabilities of experimental medicines. Toxicology studies provide translational insight into potential adverse clinical findings, but data interpretation

Externí odkaz: https://doaj.org/article/7881aa456498428f9b206c7a58d855ee

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Akademický článek

Identification of VEGF Signaling Inhibition-Induced Glomerular Injury in Rats through Site-Specific Urinary Biomarkers

Autor: Yi Yang, Kenneth Kowalkowski, Rita Ciurlionis, Wayne R. Buck, Keith B. Glaser, Daniel H. Albert, Eric A. G. Blomme

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 23, p 12629 (2021)

Cancer therapies targeting the vascular endothelial growth factor (VEGF) signaling pathway can lead to renal damage by disrupting the glomerular ultrafiltration apparatus. The objective of the current study was to identify sensitive biomarkers for VE

Externí odkaz: https://doaj.org/article/303ab7d571f24aa7899afe4e5febdaf2

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Akademický článek

Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies

Autor: Mohan S. Rao, Terry R. Van Vleet, Rita Ciurlionis, Wayne R. Buck, Scott W. Mittelstadt, Eric A. G. Blomme, Michael J. Liguori

Publikováno v: Frontiers in Genetics, Vol 9 (2019)

Gene expression profiling is a useful tool to predict and interrogate mechanisms of toxicity. RNA-Seq technology has emerged as an attractive alternative to traditional microarray platforms for conducting transcriptional profiling. The objective of t

Externí odkaz: https://doaj.org/article/8f54e5a06be041a38c8aef764788a34c

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Akademický článek

Global Transcriptomic Profiling Using Small Volumes of Whole Blood: A Cost-Effective Method for Translational Genomic Biomarker Identification in Small Animals

Autor: Yi Yang, Eric A. G. Blomme, Michael J. Liguori, Paul M. Jung, Amy C. Ditewig, Meagan M. Fricano

Publikováno v: International Journal of Molecular Sciences, Vol 12, Iss 4, Pp 2502-2517 (2011)

Blood is an ideal tissue for the identification of novel genomic biomarkers for toxicity or efficacy. However, using blood for transcriptomic profiling presents significant technical challenges due to the transcriptomic changes induced by ex vivo han

Externí odkaz: https://doaj.org/article/d636467d74a24f9a93fa4054f7c844da

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Akademický článek

Comparison of TNFα to Lipopolysaccharide as an Inflammagen to Characterize the Idiosyncratic Hepatotoxicity Potential of Drugs: Trovafloxacin as an Example

Autor: Jeffrey F. Waring, Patricia E. Ganey, Robert A. Roth, Eric A. G. Blomme, David M. Nelson, Amy C. Ditewig, Jane F. Maddox, James P. Luyendyk, Lois D. Lehman-McKeeman, Vasanthi M. Bhaskaran, Michael J. Liguori

Publikováno v: International Journal of Molecular Sciences, Vol 11, Iss 11, Pp 4697-4714 (2010)

Idiosyncratic drug reactions (IDRs) are poorly understood, unpredictable, and not detected in preclinical studies. Although the cause of these reactions is likely multi-factorial, one hypothesis is that an underlying inflammatory state lowers the tol

Externí odkaz: https://doaj.org/article/cd16481e4a9f4fe5ad6ba562b8b8db9a

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Identification of VEGF Signaling Inhibition-Induced Glomerular Injury in Rats through Site-Specific Urinary Biomarkers

Autor: Kenneth Kowalkowski, Keith B. Glaser, Wayne R. Buck, Yi Yang, Rita Ciurlionis, Eric A. G. Blomme, Daniel H. Albert

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 12629, p 12629 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12629

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210f677cdf88bcd6d72e8a4c2ff07611
https://www.mdpi.com/1422-0067/22/23/12629

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Novel Computational Approach to Predict Off-Target Interactions for Small Molecules

Autor: Scott W. Mittelstadt, Eric A. G. Blomme, Mufeng Hu, Srinivasa R. Mantena, Mohan S. Rao, Xin Huang, Terry R. Van Vleet, Rishi R Gupta, Michael J. Liguori

Publikováno v: Frontiers in Big Data

Most small molecule drugs interact with unintended, often unknown, biological targets and these off-target interactions may lead to both preclinical and clinical toxic events. Undesired off-target interactions are often not detected using current dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ae2ac5bd03530d200ed210bd9ad037
http://europepmc.org/articles/PMC7931946

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Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies

Autor: Wayne R. Buck, Mohan S. Rao, Scott W. Mittelstadt, Rita Ciurlionis, Terry R. Van Vleet, Eric A. G. Blomme, Michael J. Liguori

Publikováno v: Frontiers in Genetics
Frontiers in Genetics, Vol 9 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68e6f13f68fe23ef312bf32ac8a264a
https://doi.org/10.3389/fgene.2018.00636

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Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury

Autor: Richard J, Weaver, Catherine, Betts, Eric A G, Blomme, Helga H J, Gerets, Klaus, Gjervig Jensen, Philip G, Hewitt, Satu, Juhila, Gilles, Labbe, Michael J, Liguori, Natalie, Mesens, Monday O, Ogese, Mikael, Persson, Jan, Snoeys, James L, Stevens, Tracy, Walker, B Kevin, Park

Publikováno v: Expert opinion on drug metabolismtoxicology. 13(7)

The liver is an important target for drug-induced toxicities. Early detection of hepatotoxic drugs requires use of well-characterized test systems, yet current knowledge, gaps and limitations of tests employed remains an important issue for drug deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a103b9bba96c164ef146861a2a771354
https://pubmed.ncbi.nlm.nih.gov/28604124

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Evaluation of miR-122 as a Serum Biomarker for Hepatotoxicity in Investigative Rat Toxicology Studies

Autor: Wayne R. Buck, V. Devanarayan, Eric A. G. Blomme, J. Maher, Bruce E. LeRoy, T. Sharapova, Michael J. Liguori

Publikováno v: Veterinary pathology. 53(1)

MicroRNAs are short noncoding RNAs involved in regulation of gene expression. Certain microRNAs, including miR-122, seem to have ideal properties as biomarkers due to good stability, high tissue specificity, and ease of detection across multiple spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c8fb0c0e145edf252b2a82bc7f7fcc5
https://pubmed.ncbi.nlm.nih.gov/26123229

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