Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Eric A. Fischer"'
Autor:
Nadine Lorenz, Uwe Scheithauer, Eric Schwarzer-Fischer, Sindy Mosch, Martin Propst, Jan Sieder-Katzmann, Christian Bach
Publikováno v:
Open Ceramics, Vol 20, Iss , Pp 100660- (2024)
The aim of this work was to gain an initial impression of the surface quality that can be achieved with additively manufactured ceramic components. For this purpose, an assessment body was generated, which has partially double-curved surfaces that ca
Externí odkaz:
https://doaj.org/article/a0aca39555f34b4695bbd8c656ee9eaa
Autor:
Zhengnian Li, Han‐Yuan Liu, Zhixiang He, Antara Chakravarty, Ryan P. Golden, Zixuan Jiang, Inchul You, Hong Yue, Katherine A. Donovan, Guangyan Du, Jianwei Che, Jason Tse, Isaac Che, Wenchao Lu, Eric S. Fischer, Tinghu Zhang, Nathanael S. Gray, Priscilla L. Yang
Publikováno v:
Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)
Abstract Targeted protein degradation has been widely adopted as a new approach to eliminate both established and previously recalcitrant therapeutic targets. Here, it is reported that the development of small molecule degraders of the envelope (E) p
Externí odkaz:
https://doaj.org/article/d886eb34b9c74a7eabd320cf5081d214
Autor:
Han-Yuan Liu, Zhengnian Li, Theresia Reindl, Zhixiang He, Xueer Qiu, Ryan P. Golden, Katherine A. Donovan, Adam Bailey, Eric S. Fischer, Tinghu Zhang, Nathanael S. Gray, Priscilla L. Yang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Viral genetic diversity presents significant challenges in developing antivirals with broad-spectrum activity and high barriers to resistance. Here we report development of proteolysis targeting chimeras (PROTACs) targeting the dengue virus
Externí odkaz:
https://doaj.org/article/7d9b7ee5a0a0432baec898202007a68e
Autor:
Lena-Christin Ingwersen, Matthias Ahlhelm, Eric Schwarzer-Fischer, Sascha Kurz, Elena Riemer, Hendrik Naujokat, Klaas Loger, Rainer Bader, Anika Jonitz-Heincke
Publikováno v:
Materials & Design, Vol 238, Iss , Pp 112687- (2024)
This study deals with synthetic biomaterials that are biocompatible and mechanically stable to serve as a potential bone graft for improved mandibular reconstruction. To fabricate novel hybrid scaffolds containing beta-tricalcium phosphate (β-TCP) a
Externí odkaz:
https://doaj.org/article/fb218d77128c472e894969f005f51043
Autor:
Christof Koplin, Eric Schwarzer-Fischer, Eveline Zschippang, Yannick Marian Löw, Martin Czekalla, Arthur Seibel, Anna Rörich, Joachim Georgii, Felix Güttler, Sinef Yarar-Schlickewei, Andreas Kailer
Publikováno v:
J, Vol 6, Iss 1, Pp 180-197 (2023)
When finger joints become immobile due to an accident during sports or a widespread disease such as rheumatoid arthritis, customised finger joint implants are to be created. In an automated process chain, implants will be produced from ceramic or met
Externí odkaz:
https://doaj.org/article/7716d1c1e9da4404bb816a6b451a27e6
Autor:
Uwe Scheithauer, Tetyana Romanova, Oleksandr Pankratov, Eric Schwarzer-Fischer, Martin Schwentenwein, Florian Ertl, Andreas Fischer
Publikováno v:
Ceramics, Vol 6, Iss 1, Pp 630-650 (2023)
Thanks to the layer-by-layer creation of components, additive manufacturing (AM) processes enable the flexible production of components with highly complex geometries, that were previously not realizable or only with very great effort. While AM techn
Externí odkaz:
https://doaj.org/article/a1a42d197df447a49b37fab20a773916
Publikováno v:
Ceramics, Vol 6, Iss 1, Pp 416-431 (2023)
Aluminum nitride (AlN) is an excellent material for heat sinks and is used, for example, in high-performance electronics, high-power LEDs and photovoltaics. In order to meet the constantly increasing demands on substrate materials and heat sinks resu
Externí odkaz:
https://doaj.org/article/d02e34af5a2b44b0beeb1390ac4c2625
Autor:
Wubing Zhang, Shourya S. Roy Burman, Jiaye Chen, Katherine A. Donovan, Yang Cao, Chelsea Shu, Boning Zhang, Zexian Zeng, Shengqing Gu, Yi Zhang, Dian Li, Eric S. Fischer, Collin Tokheim, X. Shirley Liu
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 20, Iss 5, Pp 882-898 (2022)
Targeted protein degradation (TPD) has rapidly emerged as a therapeutic modality to eliminate previously undruggable proteins by repurposing the cell’s endogenous protein degradation machinery. However, the susceptibility of proteins for targeting
Externí odkaz:
https://doaj.org/article/e1cece95525d43e4af03b52377a9d03e
Autor:
Julie K. Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A. Donovan, Michelle W. Ma, Cyrus Y. Jin, Marilyn Leonard, Eric S. Fischer, Eric J. Bennett
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112496- (2023)
Summary: HUWE1 is a large, enigmatic HECT-domain ubiquitin ligase implicated in the regulation of diverse pathways, including DNA repair, apoptosis, and differentiation. How HUWE1 engages its structurally diverse substrates and how HUWE1 activity is
Externí odkaz:
https://doaj.org/article/adc1daeb5c5d4f8581b20f042daa562e
Autor:
Charles Zou, Hojong Yoon, Paul M.C. Park, J.J. Patten, Jesse Pellman, Jeannie Carreiro, Jonathan M. Tsai, Yen-Der Li, Shourya S. Roy Burman, Katherine A. Donovan, Jessica Gasser, Adam S. Sperling, Radosław P. Nowak, Eric S. Fischer, Robert A. Davey, Benjamin L. Ebert, Mikołaj Słabicki
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106601- (2023)
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) hijacks multiple human proteins during infection and viral replication. To examine whether any viral proteins employ human E3 ubiquitin ligases, we evaluated the stability of SARS-
Externí odkaz:
https://doaj.org/article/cb16503b59c14a149316faaa454be17e