Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Eric A W Slob"'
The identification of mediating effects using genome-based restricted maximum likelihood estimation.
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010638 (2023)
Mediation analysis is commonly used to identify mechanisms and intermediate factors between causes and outcomes. Studies drawing on polygenic scores (PGSs) can readily employ traditional regression-based procedures to assess whether trait M mediates
Externí odkaz:
https://doaj.org/article/7f914e77cff64f77854d736e19623472
Autor:
Alisha Aman, Eric A W Slob, Joey Ward, Breda Cullen, Nicholas Graham, Donald M Lyall, Naveed Sattar, Rona J Strawbridge
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279381 (2022)
Prescription of PCSK9-inhibitors has increased in recent years but not much is known about its off-target effects. PCSK9-expression is evident in non-hepatic tissues, notably the brain, and genetic variation in the PCSK9 locus has recently been shown
Externí odkaz:
https://doaj.org/article/c4f6534f0ef64dc2b636c2ff58463ffc
Autor:
Eric A W Slob, Cornelius A Rietveld
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259210 (2021)
BackgroundTobacco consumption is one of the leading causes of preventable death. In this study, we analyze whether someone's genetic predisposition to smoking moderates the response to tobacco excise taxes.MethodsWe interact polygenic scores for smok
Externí odkaz:
https://doaj.org/article/40514eacc9354d4785f349fec3b23b9a
Autor:
Bilal Rayes, Maddalena Ardissino, Eric A. W. Slob, Kiran Haresh Kumar Patel, Joanna Girling, Fu Siong Ng
Publikováno v:
JAMA network open, 6(2). American Medical Association
ImportanceHypertensive disorders in pregnancy (HDPs) are major causes of maternal and fetal morbidity and are observationally associated with future maternal risk of cardiovascular disease. However, observational results may be subject to residual co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f569c7637c9642dbdba75428819be9a7
https://doi.org/10.1001/jamanetworkopen.2023.0034
https://doi.org/10.1001/jamanetworkopen.2023.0034
Autor:
Philip R. Jansen, Patrick J. F. Groenen, Cornelius A. Rietveld, Ronald de Vlaming, Alain Dagher, Philipp Koellinger, Eric A. W. Slob
Publikováno v:
Communications Biology
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications biology, vol. 4, 1180, pp. 1-9 . https://doi.org/10.1038/s42003-021-02712-y
Communications Biology, 4(1):1180. Springer Nature
Communications biology, 4:1180, 1-9. Nature Research
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications Biology, vol. 4, no. 1, 1180 . https://doi.org/10.1038/s42003-021-02712-y
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P, Groenen, P J F & Rietveld, C A 2021 ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ' bioRxiv, bioRxiv . https://doi.org/10.1101/2021.04.19.440478
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications biology, vol. 4, 1180, pp. 1-9 . https://doi.org/10.1038/s42003-021-02712-y
Communications Biology, 4(1):1180. Springer Nature
Communications biology, 4:1180, 1-9. Nature Research
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications Biology, vol. 4, no. 1, 1180 . https://doi.org/10.1038/s42003-021-02712-y
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P, Groenen, P J F & Rietveld, C A 2021 ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ' bioRxiv, bioRxiv . https://doi.org/10.1101/2021.04.19.440478
Human variation in brain morphology and behavior are related and highly heritable. Yet, it is largely unknown to what extent specific features of brain morphology and behavior are genetically related. Here, we introduce a computationally efficient ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c069ca86ebfb6186627a8a306e0d249
https://doi.org/10.1038/s42003-021-02712-y
https://doi.org/10.1038/s42003-021-02712-y
Autor:
Cornelius A. Rietveld, Eric A. W. Slob
Tobacco consumption is one of the leading causes of preventable death. While some public policies have been effective in reducing the smoking prevalence in the United States, high tobacco excise taxes do not appear to deter all individuals from start
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0494689f9a36fe4896c69ded06cb12a6
https://doi.org/10.1101/2020.12.02.20242388
https://doi.org/10.1101/2020.12.02.20242388
Publikováno v:
Small Business Economics. Springer Netherlands
Studies analyzing the heritability of entrepreneurship indicate that explanations for why people engage in entrepreneurship that ignore genes are incomplete. However, despite promises that were solidly backed up with ex ante power calculations, attem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ec075a949aedf57b2c21a2fcec825a
https://pure.eur.nl/en/publications/8a532071-88e2-4c83-9076-329745643c35
https://pure.eur.nl/en/publications/8a532071-88e2-4c83-9076-329745643c35
Autor:
Eric A. W. Slob, Stephen Burgess
Publikováno v:
Genetic Epidemiology
Genetic Epidemiology, 44(4), 313-329. Wiley-Liss Inc.
Genetic Epidemiology, 44(4), 313-329. Wiley-Liss Inc.
The number of Mendelian randomization analyses including large numbers of genetic variants is rapidly increasing. This is due to the proliferation of genome-wide association studies, and the desire to obtain more precise estimates of causal effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787bd6ba3fc57fe3d2f55513fb6204d2
Publikováno v:
International Journal of Epidemiology
International Journal of Epidemiology, 46(6), 2094-2097. Oxford University Press
International Journal of Epidemiology, 46(6), 2094-2097. Oxford University Press
A large number of epidemiological studies use genetic variants as instrumental variables to infer causal relationships. For a genetic variant to be a valid instrument in these so-called Mendelian randomization (MR) studies, three assumptions need to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422471029b62672ee1b95795c2e8a222
https://pubmed.ncbi.nlm.nih.gov/29025021
https://pubmed.ncbi.nlm.nih.gov/29025021
Autor:
Hans van Kippersluis, Pietro Biroli, Rita Dias Pereira, Titus J. Galama, Stephanie von Hinke, S. Fleur W. Meddens, Dilnoza Muslimova, Eric A. W. Slob, Ronald de Vlaming, Cornelius A. Rietveld
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Measurement error in polygenic indices (PGIs) attenuates the estimation of their effects in regression models. We analyze and compare two approaches addressing this attenuation bias: Obviously Related Instrumental Variables (ORIV) and the PG
Externí odkaz:
https://doaj.org/article/9b2301c9e74b47289315b4c95041393b