Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Eric A W Slob"'
Autor:
Hans van Kippersluis, Pietro Biroli, Rita Dias Pereira, Titus J. Galama, Stephanie von Hinke, S. Fleur W. Meddens, Dilnoza Muslimova, Eric A. W. Slob, Ronald de Vlaming, Cornelius A. Rietveld
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Measurement error in polygenic indices (PGIs) attenuates the estimation of their effects in regression models. We analyze and compare two approaches addressing this attenuation bias: Obviously Related Instrumental Variables (ORIV) and the PG
Externí odkaz:
https://doaj.org/article/9b2301c9e74b47289315b4c95041393b
Autor:
Maddalena Ardissino, Eric A. W. Slob, Skanda Rajasundaram, Rohin K. Reddy, Benjamin Woolf, Joanna Girling, Mark R. Johnson, Fu Siong Ng, Dipender Gill
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-10 (2022)
Abstract Background Beta-blocker (BB) and calcium channel blocker (CCB) antihypertensive drugs are commonly used in pregnancy. However, data on their relative impact on maternal and foetal outcomes are limited. We leveraged genetic variants mimicking
Externí odkaz:
https://doaj.org/article/ef54e1af48f94ad385a08513f5d6572a
Multivariate estimation of factor structures of complex traits using SNP-based genomic relationships
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Heritability and genetic correlation can be estimated from genome-wide single-nucleotide polymorphism (SNP) data using various methods. We recently developed multivariate genomic-relatedness-based restricted maximum likelihood (MG
Externí odkaz:
https://doaj.org/article/4fc565e0deb04703976500ec4dd8d233
Autor:
Maddalena Ardissino, Eric A. W. Slob, Paul Carter, Tormod Rogne, Joanna Girling, Stephen Burgess, Fu Siong Ng
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 5 (2023)
Background Observational studies suggest that reproductive factors are associated with cardiovascular disease, but these are liable to influence by residual confounding. This study explores the causal relevance of reproductive factors on cardiovascul
Externí odkaz:
https://doaj.org/article/cbc5ae82a0c04faf9a9dad476effc211
The identification of mediating effects using genome-based restricted maximum likelihood estimation.
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010638 (2023)
Mediation analysis is commonly used to identify mechanisms and intermediate factors between causes and outcomes. Studies drawing on polygenic scores (PGSs) can readily employ traditional regression-based procedures to assess whether trait M mediates
Externí odkaz:
https://doaj.org/article/7f914e77cff64f77854d736e19623472
Autor:
Ronald de Vlaming, Eric A. W. Slob, Philip R. Jansen, Alain Dagher, Philipp D. Koellinger, Patrick J. F. Groenen, Cornelius A. Rietveld
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Ronald de Vlaming and Eric Slob et al. present MGREML, a multivariate tool to estimate pairwise genetic correlations between multiple traits. They apply MGREML to UK Biobank data for 74 brain imaging phenotypes and 8 behavioral traits, demonstrating
Externí odkaz:
https://doaj.org/article/61965f8c3cfa45558858895d9c0d260e
Autor:
Alisha Aman, Eric A W Slob, Joey Ward, Breda Cullen, Nicholas Graham, Donald M Lyall, Naveed Sattar, Rona J Strawbridge
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279381 (2022)
Prescription of PCSK9-inhibitors has increased in recent years but not much is known about its off-target effects. PCSK9-expression is evident in non-hepatic tissues, notably the brain, and genetic variation in the PCSK9 locus has recently been shown
Externí odkaz:
https://doaj.org/article/c4f6534f0ef64dc2b636c2ff58463ffc
Autor:
Eric A. W. Slob, Cornelius A. Rietveld
Publikováno v:
PLoS ONE, Vol 16, Iss 11 (2021)
Background Tobacco consumption is one of the leading causes of preventable death. In this study, we analyze whether someone’s genetic predisposition to smoking moderates the response to tobacco excise taxes. Methods We interact polygenic scores for
Externí odkaz:
https://doaj.org/article/caaf36e918c440699bdbc2059f4aaeb0
Autor:
Bilal Rayes, Maddalena Ardissino, Eric A. W. Slob, Kiran Haresh Kumar Patel, Joanna Girling, Fu Siong Ng
Publikováno v:
JAMA network open, 6(2). American Medical Association
ImportanceHypertensive disorders in pregnancy (HDPs) are major causes of maternal and fetal morbidity and are observationally associated with future maternal risk of cardiovascular disease. However, observational results may be subject to residual co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f569c7637c9642dbdba75428819be9a7
https://doi.org/10.1001/jamanetworkopen.2023.0034
https://doi.org/10.1001/jamanetworkopen.2023.0034
Autor:
Philip R. Jansen, Patrick J. F. Groenen, Cornelius A. Rietveld, Ronald de Vlaming, Alain Dagher, Philipp Koellinger, Eric A. W. Slob
Publikováno v:
Communications Biology
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications biology, vol. 4, 1180, pp. 1-9 . https://doi.org/10.1038/s42003-021-02712-y
Communications Biology, 4(1):1180. Springer Nature
Communications biology, 4:1180, 1-9. Nature Research
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications Biology, vol. 4, no. 1, 1180 . https://doi.org/10.1038/s42003-021-02712-y
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P, Groenen, P J F & Rietveld, C A 2021 ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ' bioRxiv, bioRxiv . https://doi.org/10.1101/2021.04.19.440478
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications biology, vol. 4, 1180, pp. 1-9 . https://doi.org/10.1038/s42003-021-02712-y
Communications Biology, 4(1):1180. Springer Nature
Communications biology, 4:1180, 1-9. Nature Research
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P D, Groenen, P J F & Rietveld, C A 2021, ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ', Communications Biology, vol. 4, no. 1, 1180 . https://doi.org/10.1038/s42003-021-02712-y
de Vlaming, R, Slob, E A W, Jansen, P R, Dagher, A, Koellinger, P, Groenen, P J F & Rietveld, C A 2021 ' Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior ' bioRxiv, bioRxiv . https://doi.org/10.1101/2021.04.19.440478
Human variation in brain morphology and behavior are related and highly heritable. Yet, it is largely unknown to what extent specific features of brain morphology and behavior are genetically related. Here, we introduce a computationally efficient ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c069ca86ebfb6186627a8a306e0d249
https://doi.org/10.1038/s42003-021-02712-y
https://doi.org/10.1038/s42003-021-02712-y