Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP.

Autor: Danijela Koppers-Lalic, Marieke C Verweij, Andrea D Lipińska, Ying Wang, Edwin Quinten, Eric A Reits, Joachim Koch, Sandra Loch, Marisa Marcondes Rezende, Franz Daus, Krystyna Bieńkowska-Szewczyk, Nikolaus Osterrieder, Thomas C Mettenleiter, Mirjam H M Heemskerk, Robert Tampé, Jacques J Neefjes, Shafiqul I Chowdhury, Maaike E Ressing, Frans A M Rijsewijk, Emmanuel J H J Wiertz

Publikováno v: PLoS Pathogens, Vol 4, Iss 5, p e1000080 (2008)

Cytotoxic T-lymphocytes play an important role in the protection against viral infections, which they detect through the recognition of virus-derived peptides, presented in the context of MHC class I molecules at the surface of the infected cell. The

Externí odkaz: https://doaj.org/article/81655c8859bb45398e9374c1f1a2d239

Nucleocapsid protein accumulates in renal tubular epithelium of a post-COVID-19 patient

Autor: Anita E. Grootemaat, Niek Wiersma, Sanne van der Niet, Irene M. Schimmel, Sandrine Florquin, Eric A. Reits, Sara E. Miller, Nicole N. van der Wel

Publikováno v: Microbiology Spectrum, Vol 11, Iss 6 (2023)

ABSTRACT In this study, we investigated whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins and virus particles can be detected (i) in post-mortem kidney of fatal coronavirus disease 2019 (COVID-19) patients and (ii) i

Externí odkaz: https://doaj.org/article/9d7d820279094e5d828e7e4800f35143

Lipid and Nucleocapsid N-Protein Accumulation in COVID-19 Patient Lung and Infected Cells

Autor: Anita E. Grootemaat, Sanne van der Niet, Edwin R. Scholl, Eva Roos, Bernadette Schurink, Marianna Bugiani, Sara E. Miller, Per Larsen, Jeannette Pankras, Eric A. Reits, Nicole N. van der Wel

Publikováno v: Microbiology spectrum, 10(1):e01271-21. American Society for Microbiology
Grootemaat, A E, van der Niet, S, Scholl, E R, Roos, E, Schurink, B, Bugiani, M, Miller, S E, Larsen, P, Pankras, J, Reits, E A & van der Wel, N N 2022, ' Lipid and Nucleocapsid N-Protein Accumulation in COVID-19 Patient Lung and Infected Cells ', Microbiology spectrum, vol. 10, no. 1, e01271-21 . https://doi.org/10.1128/spectrum.01271-21

The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global outbreak and prompted an enormous research effort. Still, the subcellular localization of the coronavirus in lungs of COVID-19 patients is not well u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a3fc23b9dd135aae7f998c02265a4ad
https://pure.amc.nl/en/publications/lipid-and-nucleocapsid-nprotein-accumulation-in-covid19-patient-lung-and-infected-cells(2c15d6dd-922d-4f0f-9010-88aebfa8b327).html

IL-1R1 dependent signals improve clearance of cytosolic virulent mycobacteria in vivo

Autor: Anita E. Grootemaat, Katrin D. Mayer-Barber, Sanne van der Niet, Roland Brosch, Diane Houben, Astrid M. van der Sar, Wilbert Bitter, Maaike van Zon, Maria T. Pena, Peter J. Peters, Eric E Reits, Karin de Punder, Nicole N. van der Wel, Simone J.C.F.M. Moorlag, Rogelio Hernandez, Sofie Rutten

Mycobacterium tuberculosis infections claim more than a million lives each year and better treatments or vaccines are required. A crucial pathogenicity factor is translocation from the phago-lysosomes to the cytosol upon phagocytosis by macrophages.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5535d939d3feb194e6fc84c33a3dab4d
https://doi.org/10.1101/2020.09.27.315739

Frequency of nuclear mutant huntingtin inclusion formation in neurons and glia is cell-type-specific

Autor: Anne H P, Jansen, Maurik, van Hal, Ilse C, Op den Kelder, Romy T, Meier, Anna-Aster, de Ruiter, Menno H, Schut, Donna L, Smith, Corien, Grit, Nieske, Brouwer, Willem, Kamphuis, H W G M, Boddeke, Wilfred F A, den Dunnen, Willeke M C, van Roon, Gillian P, Bates, Elly M, Hol, Eric A, Reits

Publikováno v: Glia

Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder that is caused by a CAG expansion in the Huntingtin (HTT) gene, leading to HTT inclusion formation in the brain. The mutant huntingtin protein (mHTT) is ubiquitou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30dfe1e8e85fdb908324c0e58dcaedec
https://pubmed.ncbi.nlm.nih.gov/27615381