Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Eric A Mellon"'
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0191036 (2018)
Inverse planning is trial-and-error iterative process. This work introduces a fully automated inverse optimization approach, where the treatment plan is closely tailored to the unique patient anatomy. The auto-optimization is applied to pancreatic st
Externí odkaz:
https://doaj.org/article/f551e50740884929b9f55347e8493e27
Autor:
Anuradha G. Trivedi, Su Hyun Kim, Karthik K. Ramesh, Alexander S. Giuffrida, Brent D. Weinberg, Eric A. Mellon, Lawrence R. Kleinberg, Peter B. Barker, Hui Han, Hui-Kuo G. Shu, Hyunsuk Shim, Eduard Schreibmann
Publikováno v:
Tomography, Vol 9, Iss 3, Pp 1052-1061 (2023)
Accurate radiation therapy (RT) targeting is crucial for glioblastoma treatment but may be challenging using clinical imaging alone due to the infiltrative nature of glioblastomas. Precise targeting by whole-brain spectroscopic MRI, which maps tumor
Externí odkaz:
https://doaj.org/article/5e485b96372241f582bdefa0ac6356d7
Autor:
Jonathan B. Bell, William Jin, Mohammed Z. Goryawala, Gregory A. Azzam, Matthew C. Abramowitz, Tejan Diwanji, Michael E. Ivan, Maria del Pilar Guillermo Prieto Eibl, Macarena I. de la Fuente, Eric A. Mellon
Publikováno v:
Radiation Oncology, Vol 18, Iss 1, Pp 1-8 (2023)
Abstract Background Glioblastoma (GBM) cellularity correlates with whole brain spectroscopic MRI (sMRI) generated relative choline to N-Acetyl-Aspartate ratio (rChoNAA) mapping. In recurrent GBM (rGBM), tumor volume (TV) delineation is challenging an
Externí odkaz:
https://doaj.org/article/2c2f8cec5a8147c0872508e5ed6a78f1
Autor:
Karthik K. Ramesh, Vicki Huang, Jeffrey Rosenthal, Eric A. Mellon, Mohammed Goryawala, Peter B. Barker, Saumya S. Gurbani, Anuradha G. Trivedi, Alexander S. Giuffrida, Eduard Schreibmann, Hui Han, Macarena de le Fuente, Erin M. Dunbar, Matthias Holdhoff, Lawrence R. Kleinberg, Hui-Kuo G. Shu, Hyunsuk Shim, Brent D. Weinberg
Publikováno v:
Tomography, Vol 9, Iss 1, Pp 362-374 (2023)
Glioblastoma (GBM) is a fatal disease, with poor prognosis exacerbated by difficulty in assessing tumor extent with imaging. Spectroscopic MRI (sMRI) is a non-contrast imaging technique measuring endogenous metabolite levels of the brain that can ser
Externí odkaz:
https://doaj.org/article/7e1bf384b7a148daa2140d6801c84cdc
Autor:
Adrian L. Breto, Kaylie Cullison, Evangelia I. Zacharaki, Veronica Wallaengen, Danilo Maziero, Kolton Jones, Alessandro Valderrama, Macarena I. de la Fuente, Jessica Meshman, Gregory A. Azzam, John C. Ford, Radka Stoyanova, Eric A. Mellon
Publikováno v:
Cancers, Vol 15, Iss 21, p 5241 (2023)
Glioblastoma changes during chemoradiotherapy are inferred from high-field MRI before and after treatment but are rarely investigated during radiotherapy. The purpose of this study was to develop a deep learning network to automatically segment gliob
Externí odkaz:
https://doaj.org/article/e7c65f6205514f3eb78de8882d7c97f1
Autor:
Karthik K. Ramesh, Karen M. Xu, Anuradha G. Trivedi, Vicki Huang, Vahid Khalilzad Sharghi, Lawrence R. Kleinberg, Eric A. Mellon, Hui-Kuo G. Shu, Hyunsuk Shim, Brent D. Weinberg
Publikováno v:
Cancers, Vol 15, Iss 15, p 3956 (2023)
Glioblastoma (GBM) has a poor survival rate even with aggressive surgery, concomitant radiation therapy (RT), and adjuvant chemotherapy. Standard-of-care RT involves irradiating a lower dose to the hyperintense lesion in T2-weighted fluid-attenuated
Externí odkaz:
https://doaj.org/article/aca9332a0a5445f69643065783db7ad4
Autor:
Anuradha G. Trivedi, Karthik K. Ramesh, Vicki Huang, Eric A. Mellon, Peter B. Barker, Lawrence R. Kleinberg, Brent D. Weinberg, Hui-Kuo G. Shu, Hyunsuk Shim
Publikováno v:
Cancers, Vol 15, Iss 13, p 3524 (2023)
Despite aggressive treatment, glioblastoma has a poor prognosis due to its infiltrative nature. Spectroscopic MRI-measured brain metabolites, particularly the choline to N-acetylaspartate ratio (Cho/NAA), better characterizes the extent of tumor infi
Externí odkaz:
https://doaj.org/article/d6f908a72e864f2a914f813d52df29dd
Autor:
Adrian L. Breto, Benjamin Spieler, Olmo Zavala-Romero, Mohammad Alhusseini, Nirav V. Patel, David A. Asher, Isaac R. Xu, Jacqueline B. Baikovitz, Eric A. Mellon, John C. Ford, Radka Stoyanova, Lorraine Portelance
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Background/HypothesisMRI-guided online adaptive radiotherapy (MRI-g-OART) improves target coverage and organs-at-risk (OARs) sparing in radiation therapy (RT). For patients with locally advanced cervical cancer (LACC) undergoing RT, changes in bladde
Externí odkaz:
https://doaj.org/article/f416a47054234a139ea7e17848c6709f
Autor:
Beatriz Guevara, Kaylie Cullison, Danilo Maziero, Gregory A. Azzam, Macarena I. De La Fuente, Karen Brown, Alessandro Valderrama, Jessica Meshman, Adrian Breto, John Chetley Ford, Eric A. Mellon
Publikováno v:
Cancers, Vol 15, Iss 5, p 1555 (2023)
During radiation therapy (RT) of glioblastoma, daily MRI with combination MRI–linear accelerator (MRI–Linac) systems has demonstrated significant anatomic changes, including evolving post-surgical cavity shrinkage. Cognitive function RT for brain
Externí odkaz:
https://doaj.org/article/4b142695362144ff8e38ccee74f1b6b8
Autor:
Soumon Rudra, Naomi Jiang, Stephen A. Rosenberg, Jeffrey R. Olsen, Michael C. Roach, Leping Wan, Lorraine Portelance, Eric A. Mellon, Anna Bruynzeel, Frank Lagerwaard, Michael F. Bassetti, Parag J. Parikh, Percy P. Lee
Publikováno v:
Cancer Medicine, Vol 8, Iss 5, Pp 2123-2132 (2019)
Abstract Background Adaptive magnetic resonance imaging‐guided radiation therapy (MRgRT) can escalate dose to tumors while minimizing dose to normal tissue. We evaluated outcomes of inoperable pancreatic cancer patients treated using MRgRT with and
Externí odkaz:
https://doaj.org/article/f30e8ac561b748a5a3604eb81c6ea0df