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pro vyhledávání: '"Eric A J Simko"'
G-quadruplexes offer a conserved structural motif for NONO recruitment to NEAT1 architectural lncRNA
Autor:
Adan Velasquez, Tao Zhang, Shraddha Teli, Jiou Wang, Hong-he Liu, Eric A J Simko, Aaron R. Haeusler
Publikováno v:
Nucleic Acids Research
The long non-coding RNA NEAT1 serves as a scaffold for the assembly of paraspeckles, membraneless nuclear organelles involved in gene regulation. Paraspeckle assembly requires NEAT1 recruitment of the RNA-binding protein NONO, however the NEAT1 eleme
Autor:
Christopher J. Donnelly, Jeffrey D. Rothstein, Eric A J Simko, Aaron R. Haeusler, Juan C. Troncoso, Nicholas J. Maragakis, Min-Sik Kim, Jiou Wang, Rita Sattler, Akhilesh Pandey, Patrick G. Shaw, Goran Periz
Publikováno v:
Nature
Summary A hexanucleotide repeat expansion (HRE), (GGGGCC)n, in C9orf72 is the most common genetic cause of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we identify a molecular mechanism by
RNA plays an active role in structural polymorphism of the genome through the formation of stable RNA•DNA hybrids (R-loops). R-loops can modulate normal physiological processes and are also associated with pathological conditions, such as those rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34e7e18385fd3e139e165ef371be2eb
https://europepmc.org/articles/PMC4614400/
https://europepmc.org/articles/PMC4614400/