Zobrazeno 1 - 10
of 532
pro vyhledávání: '"Eric A, Schmidt"'
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110834- (2024)
Summary: The varied pigments found in animals play both ecological and physiological roles. Virtually all echinoderms contain putative pigment biosynthetic enzymes, the polyketide synthases (PKSs). Among these, crinoids have complex pigments found bo
Externí odkaz:
https://doaj.org/article/db910d340f3046fba0eee822f02f98e2
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Animals synthesize simple lipids using a distinct fatty acid synthase (FAS) related to the type I polyketide synthase (PKS) enzymes that produce complex specialized metabolites. The evolutionary origin of the animal FAS and its relationship
Externí odkaz:
https://doaj.org/article/a1c8dbea0fb34a798fadcda3fcf72d7a
Autor:
Heidi A. Crosby, Klara Keim, Jakub M. Kwiecinski, Christophe J. Langouët-Astrié, Kaori Oshima, Wells B. LaRivière, Eric P. Schmidt, Alexander R. Horswill
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTStaphylococcus aureus is one of the leading causes of hospital-acquired infections, many of which begin following attachment and accumulation on indwelling medical devices or diseased tissue. These infections are often linked to the establish
Externí odkaz:
https://doaj.org/article/58e55729bb694669b833e2b8a927e904
Autor:
Sarah C. Katsandres, Jane Hall, Kyle Danielson, Sana Sakr, Sarah G. Dean, David J. Carlbom, Mark M. Wurfel, Pavan K. Bhatraju, Joseph A. Hippensteel, Eric P. Schmidt, Kaori Oshima, Catherine R. Counts, Michael R. Sayre, Daniel J. Henning, Nicholas J. Johnson
Publikováno v:
Resuscitation Plus, Vol 17, Iss , Pp 100590- (2024)
Background: Acute respiratory distress syndrome (ARDS) is often seen in patients resuscitated from out-of-hospital cardiac arrest (OHCA). We aim to test whether inflammatory or endothelial injury markers are associated with the development of ARDS in
Externí odkaz:
https://doaj.org/article/14d367a77e734af6aff90455f48a0361
Autor:
Jennifer Warner-Schmidt, Martin Stogniew, Blake Mandell, R. Scott Rowland, Eric F. Schmidt, Benjamin Kelmendi
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
BackgroundPost-traumatic stress disorder (PTSD) is a highly prevalent psychiatric disorder that can become chronic and debilitating when left untreated. Available pharmacotherapies are limited, take weeks to show modest benefit and remain ineffective
Externí odkaz:
https://doaj.org/article/211f26b9053c4d86b492e662cd5096f8
Autor:
Albebson L. Lim, Bailey W. Miller, Zhenjian Lin, Mark A. Fisher, Louis R. Barrows, Margo G. Haygood, Eric W. Schmidt
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Turnercyclamycin A and B lipopeptides exhibit Gram-negative bacteria-specific toxicity. This includes CDC urgent threat organisms such as multidrug-resistant Acinetobacter baumannii. Like the last-line agent colistin, turnercyclamycins inter
Externí odkaz:
https://doaj.org/article/54c4046ef672420ebbd5753d2a69f3bd
Autor:
Lili Sun, Jie Zhang, Changshan Niu, Cassandra E. Deering-Rice, Ronald W. Hughen, John G. Lamb, Katherine Rose, Kevin M. Chase, Marysol Almestica-Roberts, Markel Walter, Eric W. Schmidt, Alan R. Light, Baldomero M. Olivera, Christopher A. Reilly
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 1, Pp 68-81 (2023)
Pain is often debilitating, and current treatments are neither universally efficacious nor without risks. Transient receptor potential (TRP) ion channels offer alternative targets for pain relief, but little is known about the regulation or identitie
Externí odkaz:
https://doaj.org/article/6bb12ec7d65448d6a83796dbcdf8242d
Autor:
James F. Colbert, Joshua M. Kirsch, Christopher L. Erzen, Christophe J. Langouët-Astrié, Grace E. Thompson, Sarah A. McMurtry, Jennifer M. Kofonow, Charles E. Robertson, Elizabeth J. Kovacs, Ryan C. Sullivan, Joseph A. Hippensteel, Namrata V. Sawant, Nicole J. De Nisco, Bruce D. McCollister, Robert S. Schwartz, Alexander R. Horswill, Daniel N. Frank, Breck A. Duerkop, Eric P. Schmidt
Publikováno v:
mBio, Vol 14, Iss 3 (2023)
ABSTRACT Prior research has focused on host factors as mediators of exaggerated sepsis-associated morbidity and mortality in older adults. This focus on the host, however, has failed to identify therapies that improve sepsis outcomes in the elderly.
Externí odkaz:
https://doaj.org/article/3534f0ab7eb1418a8befb8cb4e008912
Autor:
Christine U. Vohwinkel, Nana Burns, Ethan Coit, Xiaoyi Yuan, Eszter K. Vladar, Christina Sul, Eric P. Schmidt, Peter Carmeliet, Kurt Stenmark, Eva S. Nozik, Rubin M. Tuder, Holger K. Eltzschig
Publikováno v:
JCI Insight, Vol 7, Iss 24 (2022)
Acute lung injury (ALI) is a severe form of lung inflammation causing acute respiratory distress syndrome in patients. ALI pathogenesis is closely linked to uncontrolled alveolar inflammation. We hypothesize that specific enzymes of the glycolytic pa
Externí odkaz:
https://doaj.org/article/e7487e67c5aa432793b2364d3d6e26f1
Autor:
Eric W. Schmidt, Zhenjian Lin
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Chemists have studied marine animals for the better part of a century because they contain a diverse array of bioactive compounds. Tens of thousands of compounds have been reported, many with elaborate structural motifs and biological mechan
Externí odkaz:
https://doaj.org/article/10fb51b0ec0f40ecb74e07aef9f5b58b