Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Eric Van Quaquebeke"'
1
Akademický článek
UNBS5162, a Novel Naphthalimide That Decreases CXCL Chemokine Expression in Experimental Prostate Cancers
Autor: Tatjana Mijatovic, Tina Mahieu, Céline Bruyère, Nancy De Nève, Janique Dewelle, Gentiane Simon, Mischaël J.M. Dehoux, Ellen van der Aar, Benjamin Haibe-Kains, Gianluca Bontempi, Christine Decaestecker, Eric Van Quaquebeke, Francis Darro, Robert Kiss
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 6, Pp 573-586 (2008)
Several naphthalimides have been evaluated clinically as potential anticancer agents. UNBS3157, a naphthalimide that belongs to the same class as amonafide, was designed to avoid the specific activating metabolism that induces amonafide’s hematotox
Externí odkaz: https://doaj.org/article/4107d46edf0f43789479a01f83b30729
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2
Akademický článek
Cardenolide-Induced Lysosomal Membrane Permeabilization Demonstrates Therapeutic Benefits in Experimental Human Non-Small Cell Lung Cancers
Autor: Tatjana Mijatovic, Véronique Mathieu, Jean-François Gaussin, Nancy De Néve, Fabrice Ribaucour, Eric Van Quaquebeke, Patrick Dumont, Francis Darro, Robert Kiss
Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 5, Pp 402-412 (2006)
Non-small cell lung cancers (NSCLCs) are the leading cause of cancer deaths in most developed countries. Targeting heat shock protein 70 (Hsp70) expression and function, together with the induction of lysosomal membrane permeabilization (LMP), could
Externí odkaz: https://doaj.org/article/223d995ff71b41e3ae603e20fbdf5d44
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3
Cardiotonic steroids on the road to anti-cancer therapy
Autor: Eric Van Quaquebeke, Bruno Delest, Tatjana Mijatovic, Francis Darro, Robert Kiss, Olivier Debeir
Publikováno v: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1776:32-57
The sodium pump, Na(+)/K(+)-ATPase, could be an important target for the development of anti-cancer drugs as it serves as a versatile signal transducer, it is a key player in cell adhesion and its aberrant expression and activity are implicated in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c8c459785793b2db750055930512d0
https://doi.org/10.1016/j.bbcan.2007.06.002
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5
UNBS1450: A new hemi-synthetic cardenolide with promising anti-cancer activity
Autor: Eric Van Quaquebeke, Florence Lefranc, Frank Van Vynckt, Francis Darro, Robert Kiss, Tatjana Mijatovic
Publikováno v: Drug Development Research. 68:164-173
Several reports suggest the sodium pump as an interesting oncology target, given that its subunit expression is markedly altered in cancer. By binding to the sodium pump, cardiotonic steroids, notably cardenolides, the natural high-affinity Na+/K+-AT
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55a8e6f1e60fc38a49f887f9a86a131e
https://doi.org/10.1002/ddr.20178
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6
Cardenolide-Induced Lysosomal Membrane Permeabilization Demonstrates Therapeutic Benefits in Experimental Human Non-Small Cell Lung Cancers
Autor: Fabrice Ribaucour, Véronique Mathieu, Eric Van Quaquebeke, Tatjana Mijatovic, Jean-François Gaussin, Patrick Dumont, Francis Darro, Robert Kiss, Nancy De Nève
Publikováno v: Neoplasia (New York, N.Y.), 8 (5
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 5, Pp 402-412 (2006)
NeoPlasia : an international journal of oncology research, no. 8, p. 402-412 (2006)
Non-small cell lung cancers (NSCLCs) are the leading cause of cancer deaths in most developed countries. Targeting heat shock protein 70 (Hsp70) expression and function, together with the induction of lysosomal membrane permeabilization (LMP), could
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a165ed060154ef36e2a1256ecabe73d
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7
Structure-activity relationship analysis of novel derivatives of narciclasine (an Amaryllidaceae isocarbostyril derivative) as potential anticancer agents
Autor: Walter Berger, Sébastien Sauvage, Florence Lefranc, Mischaël Dehoux, Laurent Ingrassia, Laurent Pottier, Sabine Spiegl-Kreinecker, Véronique Mathieu, Mohamed El Yazidi, Eric Van Quaquebeke, Janique Dewelle, Robert Kiss
Publikováno v: Journal of medicinal chemistry. 52(4)
Narciclasine (1) is a plant growth regulator that has been previously demonstrated to be proapoptotic to cancer cells at high concentrations (or = 1 microM). Data generated in the present study show that narciclasine displays potent antitumor effects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ae3af26f278566f36e5dc200041791
https://pubmed.ncbi.nlm.nih.gov/19199649
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8
The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells
Autor: Anne Op De Beeck, Janique Dewelle, Eric Van Quaquebeke, Robert Kiss, Francis Darro, Yvan de Launoit, Tatjana Mijatovic
Publikováno v: Molecular cancer therapeutics, 5 (2
Non-small cell lung cancers (NSCLC) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and Vinca alkaloid derivatives, offers patients only slight clinical benefits. Part of the chemoresistanc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d08268b3d623d2b63837d4b6e62a2d0
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51308
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