Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Eric S. Marr"'
Autor:
Eric S. Marr, Simone Sciabola, Robin T. Nelson, Anabella Villalobos, Xiaomin Chen, Stefan Doerr, Yaozhong Zou, Michelle Vanase-Frawley, Noelia Ferruz, Gianni De Fabritiis, Travis T. Wager, Xinjun Hou, Bethany L. Kormos
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-4 (2019)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Autor:
Robin T. Nelson, Xinjun Hou, Bethany L. Kormos, Michelle Vanase-Frawley, Gianni De Fabritiis, Anabella Villalobos, Xiaomin Chen, Noelia Ferruz, Eric S. Marr, Travis T. Wager, Yaozhong Zou, Stefan Doerr, Simone Sciabola
Publikováno v:
Scientific Reports
Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Recercat. Dipósit de la Recerca de Catalunya
instname
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
The recent increase in the number of X-ray crystal structures of G-protein coupled receptors (GPCRs) has been enabling for structure-based drug design (SBDD) efforts. These structures have revealed that GPCRs are highly dynamic macromolecules whose f
Autor:
Raymond S. Hurst, Mihály Hajós, Dennis J. Hoover, William E. Hoffmann, Nandini Chaturbhai Patel, Christopher L. Shaffer, Xinjun J. Hou, Christopher J. O’Donnell, Dina McGinnis, Jayvardhan Pandit, Eric S. Marr, Randall James Gallaschun, Dianne K. Bryce, John T. Lazzaro, Longfei Xie, Jacob Bradley Schwarz, Fliri Anton F J, Justin L Gazard, Ashley N. Hanks, Renato J. Scialis
Publikováno v:
Journal of Medicinal Chemistry. 56:9180-9191
Positive allosteric modulators ("potentiators") of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPAR) enhance excitatory neurotransmission and may improve the cognitive deficits associated with various neurological disorde
Autor:
Rose Barham, Thuy Hoang, Jeremy T. Starr, Jennifer A. Young, M. Megan Lemmon, Joseph Penzien, Mark J. Mitton-Fry, Thomas M. Harris, Antonia A. Nikitenko, Brian S. Gerstenberger, Sandra P. McCurdy, Veerabahu Shanmugasundaram, Lisa Mullins, Joel R. Hardink, Jeffrey M. Casavant, Eric S. Marr, Jian Lin, Seungil Han, Joel T. Arcari, John P. Mueller, Brandon P. Schuff, Mark S. Plummer, Craig J. McPherson, Michael D. Huband, Mark C. Noe, Manjinder S. Lall, Richard P. Zaniewski, Chao Li, Matthew Frank Brown, Jianmin Sun, Eric B. McElroy, Andrew P. Tomaras
Publikováno v:
Journal of Medicinal Chemistry. 56:5541-5552
Herein we describe the structure-aided design and synthesis of a series of pyridone-conjugated monobactam analogues with in vitro antibacterial activity against clinically relevant Gram-negative species including Pseudomonas aeruginosa , Klebsiella p
Autor:
Veerabahu Shanmugasundaram, Michael D. Huband, Jinshan Michael Chen, Thuy-Trinh Nguyen, Eric S. Marr, Karl Granskog, Bruce A. Maguire, Sandra P. McCurdy, Timothy A. Subashi, Seungil Han, Magee Thomas Victor
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1727-1731
A novel series of 3- O -carbamoyl erythromycin A derived analogs, labeled carbamolides, with activity versus resistant bacterial isolates of staphylococci (including macrolide and oxazolidinone resistant strains) and streptococci are reported. An ( R
Autor:
Carol B. Fox, Spiros Liras, Douglas S. Chapin, Frederick R. Nelson, Jayvardhan Pandit, Xinjun Hou, Christopher John Helal, John M. Humphrey, Christopher J. Schmidt, Thomas Allen Chappie, Kimberly F. Fennell, Frank S. Menniti, Zhijun Kang, Julia Cianfrogna, Judith A. Siuciak, Mary C. MacDougall, Kari R. Fonseca, Rebecca E. O’Connor, Lois K. Chenard, Eric S. Marr, Lorraine A. Lebel, Laura McDowell, Robert D. Williams
Publikováno v:
Journal of Medicinal Chemistry. 54:4536-4547
Utilizing structure-based virtual library design and scoring, a novel chimeric series of phosphodiesterase 10A (PDE10A) inhibitors was discovered by synergizing binding site interactions and ADME properties of two chemotypes. Virtual libraries were d
Autor:
Artem G. Evdokimov, Veerabahu Shanmugasundaram, Seungil Han, J. Richard Miller, Eric S. Marr, Brian M. Lacey, Richard P. Zaniewski, Andrew P. Tomaras
Publikováno v:
Proceedings of the National Academy of Sciences. 107:22002-22007
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen that causes nosocomial infections for which there are limited treatment options. Penicillin-binding protein PBP3, a key therapeutic target, is an essential enzyme responsible for the f
Autor:
Ing-Kae Wang, Zuoyu Xu, Richard P. Zaniewski, Samuel P. Simons, Timothy A. Subashi, Thomas J. Dougherty, Thomas J. McLellan, Charlene R. Desbonnet, Peter K. LeMotte, Bruce A. Maguire, Paul A. Aeed, Eric S. Marr, Lillian M. Wondrack
Publikováno v:
Analytical Biochemistry. 395:77-85
We have developed an affinity purification of the large ribosomal subunit from Deinococcus radiodurans that exploits its association with FLAG-tagged 30S subunits. Thus, capture is indirect so that no modification of the 50S is required and elution i
Autor:
Christopher J. Schmidt, Frank S. Menniti, Kari R. Fonseca, Spiros Liras, Robert D. Williams, Michelle Vanase-Frawley, Frederick R. Nelson, Christopher John Helal, Eric S. Marr, Patrick Robert Verhoest, Xinjun Hou, Shenping Liu, Lois K. Chenard, Michael L. Corman, Anne W. Schmidt, Caroline Proulx-Lafrance, Robin J. Kleiman
Publikováno v:
Journal of Medicinal Chemistry. 52:7946-7949
By use of chemical enablement and prospective design, a novel series of selective, brain penetrant PDE9A inhibitors have been identified that are capable of producing in vivo elevations of brain cGMP.
Autor:
Eric S. Marr, Timothy A. Subashi, Bruce A. Maguire, Seungil Han, Ing-Kae Wang, Lillian M. Wondrack, Thomas J. McLellan, Paul A. Aeed, Zuoyu Xu
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 65:1270-1282
A systematic analysis was undertaken to seek correlations between the integrity, purity and activity of 50S ribosomal subunit preparations from Deinococcus radiodurans and their ability to crystallize. Conditions of fermentation, purification and cry