A glycosyltransferase gene signature to detect pancreatic ductal adenocarcinoma patients with poor prognosis

Autor: Yousra Mohamed Abd-El-Halim, Abdessamad El Kaoutari, Françoise Silvy, Marion Rubis, Martin Bigonnet, Julie Roques, Jérôme Cros, Rémy Nicolle, Juan Iovanna, Nelson Dusetti, Eric Mas

Publikováno v: EBioMedicine, Vol 71, Iss , Pp 103541- (2021)

Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by an important heterogeneity, reflected by different clinical outcomes and chemoresistance. During carcinogenesis, tumor cells display aberrant glycosylated structures, synthetized

Externí odkaz: https://doaj.org/article/6bdc66b51d9a458a9e97509acbe65ac8

Data from Monoclonal antibody 16D10 to the COOH-terminal domain of the feto-acinar pancreatic protein targets pancreatic neoplastic tissues

Autor: Eric Mas, Dominique Lombardo, François Romagné, Laurent Gauthier, Françoise Silvy, Pierre Bongrand, Anne-Marie Benoliel, José Sahel, Bernard Sastre, Mehdi Ouaissi, Mireille Delmas, Cécile Franceschi, Lydie Crescence, Marie-José Payan-Defais, Jean-Paul Bernard, Liliane Benkoël

We have shown that the 16D10 antigen located on the mucin-like COOH-terminal domain of the feto-acinar pancreatic protein (FAPP) is expressed at the surface of human pancreatic tumor cell lines such as SOJ-6 cell line. Furthermore, an in vivo study i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07884d1d86017430d7b37a14b3a0788
https://doi.org/10.1158/1535-7163.c.6531690.v1

Dendritic cell-based vaccination: powerful resources of immature dendritic cells against pancreatic adenocarcinoma

Autor: Aurélie Collignon, Françoise Silvy, Stéphane Robert, Malika Trad, Sébastien Germain, Jérémy Nigri, Frédéric André, Véronique Rigot, Richard Tomasini, Bernard Bonnotte, Dominique Lombardo, Eric Mas, Evelyne Beraud

Publikováno v: OncoImmunology, Vol 7, Iss 12 (2018)

Pancreatic adenocarcinoma (PAC) has a poor prognosis. One treatment approach, investigated here, is to reinforce antitumor immunity. Dendritic cells (DCs) are essential for the development and regulation of adaptive host immune responses against tumo

Externí odkaz: https://doaj.org/article/64caf32902694b35a6197ca1d25f0fab

Monoclonal Antibody 16D10 to the C-Terminal Domain of the Feto-Acinar Pancreatic Protein Binds to Membrane of Human Pancreatic Tumoral SOJ-6 Cells and Inhibits the Growth of Tumor Xenografts

Autor: Laurence Panicot-Dubois, Muriel Aubert, Cécile Franceschi, Eric Mas, Françoise Silvy, Christian Crotte, Jean-Paul Bernard, Dominique Lombardo, Marie-Odile Sadoulet

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 6, Iss 6, Pp 713-724 (2004)

Feto-acinar pancreatic protein (FAPP) characterized by mAbJ28 reactivity is a specific component associated with ontogenesis and behaves as an oncodevelopment-associated antigen. We attempted to determine whether pancreatic tumoral SOJ-6 cells are ex

Externí odkaz: https://doaj.org/article/3d3133d536b140168d6bf216eb21b87b

Docetaxel–trastuzumab stealth immunoliposome: development and in vitro proof of concept studies in breast cancer

Autor: Fanny Bouquet, Sarah Giacometti, Joseph Ciccolini, Bruno Lacarelle, Ariel Savina, Anne Rodallec, Jean Michel Brunel, Raphaelle Fanciullino, Helene Maccario, Florian Correard, Eric Mas, Caroline Orneto

Publikováno v: International Journal of Nanomedicine
International Journal of Nanomedicine, Dove Medical Press, 2018, 13, pp.3451-3465. ⟨10.2147/IJN.S162454⟩
International Journal of Nanomedicine, 2018, 13, pp.3451-3465. ⟨10.2147/IJN.S162454⟩

Background Trastuzumab plus docetaxel is a mainstay to treat HER2-positive breast cancers. However, developing nanoparticles could help to improve the efficacy/toxicity balance of this doublet by improving drug trafficking and delivery to tumors. Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad8cb7ad3b9709f53027c302e3d9d24
http://europepmc.org/articles/PMC6014390