Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Eric D. Moher"'
Autor:
Tetsuya Yamamoto, Tohru Yokozawa, Sze-Wing Wong, Radhe K. Vaid, Martin D. Johnson, Carla V. Luciani, Eric D. Moher, Shujauddin M. Changi, Hikaru Nakajima, Matthew C. Embry
Publikováno v:
Reaction Chemistry & Engineering. 2:720-739
A comprehensive assessment of a Ru-catalyzed direct asymmetric reductive amination (DARA) reaction for producing an intermediate for an active pharmaceutical ingredient (API) was carried out. Experiments were conducted to investigate the impact of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cff291e2ec1a74663d09ab60380f1b0
https://doi.org/10.1039/c7re00055c
https://doi.org/10.1039/c7re00055c
Autor:
Adam D. McFarland, Olivia Gowran, Marie Kissane, Scott A. May, Alison N. Campbell, Gordon R. Lambertus, Paul E. Sheehan, Shon Roland Pulley, Niall G. Kerrigan, Martin D. Johnson, Philip C. Hoffman, Timothy D. White, Eric D. Moher, Richard D. Spencer, Brian D. Haeberle, Aoife P. Corrigan, Scott Alan Frank, James R. Stout, D. Hurley, Regina R. Lynch, Jonas Y. Buser
Publikováno v:
Organic Process Research & Development. 20:1870-1898
The design, development, and scale up of a continuous iridium-catalyzed homogeneous high pressure reductive amination reaction to produce 6, the penultimate intermediate in Lilly’s CETP inhibitor evacetrapib, is described. The scope of this report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32bd7db8bd98561d2e637348d8e92ac8
https://doi.org/10.1021/acs.oprd.6b00148
https://doi.org/10.1021/acs.oprd.6b00148
Autor:
Charles A. Alt, Jeremy T. Spitler, Sathish K. Boini, Eric D. Moher, Chad E. Hadden, Scott Alan Frank, Radhe K. Vaid
Publikováno v:
Synthesis. 46:2463-2470
A high-yielding five-step synthesis of the title compound, methyl 7,9-dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate, starting from 2,4-dimethylaniline was developed. This synthesis involved N-alkylation of 2,4-dimethylaniline w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc99d123bce7a756e56d091e4564e0e9
https://doi.org/10.1055/s-0034-1378279
https://doi.org/10.1055/s-0034-1378279
Autor:
Sarah O’Keeffe, Rebecca E. Deasy, Humphrey A. Moynihan, Nicholas A. Magnus, Michael E. Kopach, Denis Lynch, Douglas Patton Kjell, David Mitchell, Orla A. McNamara, Catherine N. Slattery, Anita R. Maguire, Marie Kissane, Eric D. Moher
Publikováno v:
Organic Process Research & Development. 19:344-346
There is a growing trend in Ireland toward greater collaboration between academia and the pharmaceutical industry. This is an activity encouraged at a national policy level as a means of providing researchers from academic institutions the opportunit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5718c4f3e6551e8d0e5919e76f042488
https://doi.org/10.1021/op5003825
https://doi.org/10.1021/op5003825
Autor:
Martin Müllner, Kevin A. Sullivan, Michael E. Laurila, Richard D. Miller, Michael Leroy Phillips, Tanja Leitner, Mario Waser, David W. Hoard, Marvin M. Hansen, Chaoyu Xie, Marcus Kordian, Sandy S. K. Borders, Jeffrey A. Ward, Michael E. LeTourneau, Eric D. Moher, Cheryl A. Bye, Brigitte Herzog-Krimbacher
Publikováno v:
Organic Process Research & Development. 15:1266-1274
To fuel clinical development of the experimental CNS medicine LY2140023, we developed a scalable route for the multistep synthesis of a pivotal synthetic intermediate. The core of the conformationally restricted glutamic acid-based amino acid analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::864de8e0e1bf7c7dd96cc65b0fc6c539
https://doi.org/10.1021/op100325h
https://doi.org/10.1021/op100325h
Autor:
Eric D. Moher, Charles A. Alt, Chad E. Hadden, Radhe K. Vaid, Scott Alan Frank, Sathish K. Boini, Jeremy T. Spitler
Publikováno v:
ChemInform. 46
The synthesis of (Ia) on an industrial scale is elaborated and applied to the preparation of (Ib,c) and (II).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8179ead97d3a1c542e6a69e7a32c505b
https://doi.org/10.1002/chin.201509247
https://doi.org/10.1002/chin.201509247
Autor:
Thomas H. Corbett, Jian Liang, Rima S. Al-awar, Lisa Polin, David A. Hay, Chuan Shih, James Abraham Aikins, Vasu Vasudevan, Richard E. Moore, Lowell Lee Gibson, Juiwanna Kushner, Kathryn White, James Edward Ray, Michael J. Martinelli, Eric D. Moher, Susan Pugh, Varie David Lee, Tony Y. Zhang, Chiab Simpson, John E. Munroe
Publikováno v:
Investigational New Drugs. 23:213-224
Cryptophycins-1 and 52 (epoxides) were discovered to have in-vitro and in-vivo antitumor activity in the early 1990s. The chlorohydrins of these, Cryptophycins-8 and 55 (also discovered in the early 1990s) were markedly more active, but could not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc11771b8b45636496b48fe4a3174d8
https://doi.org/10.1007/s10637-005-6729-9
https://doi.org/10.1007/s10637-005-6729-9
Publikováno v:
Organic Process Research & Development. 8:593-596
The preparation of Elanco Animal Health immunopotentiator (S)-ethyl-1-(2-thiopheneacetyl)-3-piperidinecarboxylate (1) is described. The synthesis includes a new resolution of racemic ethyl nipecotate with dibenzoyl-l-tartaric acid. The resolved salt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a86b49f7b8798f9690c56c5e80ca2076
https://doi.org/10.1021/op049941c
https://doi.org/10.1021/op049941c
Autor:
Eric D. Moher, Lisa M. H. Zollars, Ulhas P. Dhokte, Naresh K. Nayyar, Michael J. Martinelli, Christopher W. Doecke, Rajappa Vaidyanathan, Vien V. Khau, Berta Kosmrlj, Pawlak Joseph Matthew
Publikováno v:
Journal of the American Chemical Society. 124:3578-3585
This paper describes a convenient protocol for the regioselective sulfonylation of alpha-chelatable alcohols. Typically, the reaction of alpha-heterosubstituted alcohols with 1 equiv of p-TsCl and 1 equiv of Et(3)N in the presence of 2 mol % of Bu(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8242174665f1627f77973a6f9caccb
https://doi.org/10.1021/ja016031r
https://doi.org/10.1021/ja016031r
Autor:
Naresh K. Nayyar, Ulhas P. Dhokte, and Joseph M. Pawlak, Eric D. Moher, Rajappa Vaidyanathan, Michael J. Martinelli
Publikováno v:
Organic Letters. 1:447-450
The reaction of substituted glycols with catalytic dibutyltin oxide, stoichiometric p-toluenesulfonyl chloride, and triethylamine in CH2Cl2 resulted in the complete and rapid sulfonylation at the primary alcohol. The α-heterosubstituted primary alco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5dc4db91aa6181f60b792606583ca3a
https://doi.org/10.1021/ol990658l
https://doi.org/10.1021/ol990658l