Zobrazeno 1 - 10 of 495 pro vyhledávání: '"Eric, Oldfield"'
1
Akademický článek
Lipophilic bisphosphonates reduced cyst burden and ameliorated hyperactivity of mice chronically infected with Toxoplasma gondii
Autor: Melissa A. Sleda, Zaid F. Pitafi, WenZhan Song, Eric Oldfield, Silvia N. J. Moreno
Publikováno v: mBio, Vol 15, Iss 11 (2024)
ABSTRACT The current treatments for toxoplasmosis are only active against fast-growing tachyzoites, present in acute infections, with little effect on slow-growing bradyzoites within tissue cysts, present in latent chronic infections. The mitochondri
Externí odkaz: https://doaj.org/article/abce50c507e74e69b5de700c2bb1266a
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2
Akademický článek
Distinct Energy-Coupling Factor Transporter Subunits Enable Flavin Acquisition and Extracytosolic Trafficking for Extracellular Electron Transfer in Listeria monocytogenes
Autor: Rafael Rivera-Lugo, Shuo Huang, Frank Lee, Raphaël Méheust, Anthony T. Iavarone, Ashley M. Sidebottom, Eric Oldfield, Daniel A. Portnoy, Samuel H. Light
Publikováno v: mBio, Vol 14, Iss 1 (2023)
ABSTRACT A variety of electron transfer mechanisms link bacterial cytosolic electron pools with functionally diverse redox activities in the cell envelope and extracellular space. In Listeria monocytogenes, the ApbE-like enzyme FmnB catalyzes extracy
Externí odkaz: https://doaj.org/article/7f74c33962af4e41a4552b9906296863
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3
Akademický článek
The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection
Autor: Melissa A. Sleda, Zhu-Hong Li, Ranjan Behera, Baihetiya Baierna, Catherine Li, Jomkwan Jumpathong, Satish R. Malwal, Makoto Kawamukai, Eric Oldfield, Silvia N. J. Moreno
Publikováno v: mBio, Vol 13, Iss 5 (2022)
ABSTRACT Prenyldiphosphate synthases catalyze the reaction of allylic diphosphates with one or more isopentenyl diphosphate molecules to form compounds such as farnesyl diphosphate, used in, e.g., sterol biosynthesis and protein prenylation, as well
Externí odkaz: https://doaj.org/article/7367969b979b4bf19003c8418411efe0
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5
Akademický článek
In Vivo Efficacy of SQ109 against Leishmania donovani, Trypanosoma spp. and Toxoplasma gondii and In Vitro Activity of SQ109 Metabolites
Autor: Kyung-Hwa Baek, Trong-Nhat Phan, Satish R. Malwal, Hyeryon Lee, Zhu-Hong Li, Silvia N. J. Moreno, Eric Oldfield, Joo Hwan No
Publikováno v: Biomedicines, Vol 10, Iss 3, p 670 (2022)
SQ109 is an anti-tubercular drug candidate that has completed Phase IIb/III clinical trials for tuberculosis and has also been shown to exhibit potent in vitro efficacy against protozoan parasites including Leishmania and Trypanosoma cruzi spp. Howev
Externí odkaz: https://doaj.org/article/21fe0bd9296f49faa14a547b0d351f5a
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7
Mycobacterial membrane protein Large 3‐like ‐family proteins in bacteria, protozoa, fungi, plants, and animals: A bioinformatics and structural investigation
Autor: Satish R. Malwal, Eric Oldfield
Publikováno v: Proteins: Structure, Function, and Bioinformatics. 90:776-790
Lipid transporters play an important role in most if not all organisms, ranging from bacteria to humans. For example, in Mycobacterium tuberculosis, the trehalose monomycolate transporter MmpL3 is involved in cell wall biosynthesis, while in humans,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f999503047395ac8f31e4cb390c71c1
https://doi.org/10.1002/prot.26273
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9
Akademický článek
Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells
Autor: Xiaoying Zhou, Yanzheng Gu, Hongying Xiao, Ning Kang, Yonghua Xie, Guangbo Zhang, Yan Shi, Xiaoyu Hu, Eric Oldfield, Xueguang Zhang, Yonghui Zhang
Publikováno v: Frontiers in Immunology, Vol 8 (2017)
Activated hepatic stellate cells (aHSCs) are now established as a central driver of fibrosis in human liver injury. In the presence of chronic or repeated injury, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) can occur, so there is interest
Externí odkaz: https://doaj.org/article/30b23b484d3245cca09eec8f84e5fae9
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10
Terpene Cyclases and Prenyltransferases: Structures and Mechanisms of Action
Autor: Xianqiang Ma, Xu Han, Rey-Ting Guo, Weidong Liu, Satish R. Malwal, Longhai Dai, Jian Wen Huang, Lixin Ma, Chun-Chi Chen, Janish Desai, Eric Oldfield, Yonghui Zhang, Alli Shillo, Chao Zhai
Publikováno v: ACS Catalysis. 11:290-303
Terpenes and isoprenoids are the most diverse small organic molecules on Earth. Here, we obtained the structures of sesquisabinene and santalene synthases from Santalum album L. in the presence or ...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::203ba97dab8bc69bf971b910da9e8ade
https://doi.org/10.1021/acscatal.0c04710
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