An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters

Autor: Henri-Baptiste Marjault, Ola Karmi, Ke Zuo, Dorit Michaeli, Yael Eisenberg-Domovich, Giulia Rossetti, Benoit de Chassey, Jacky Vonderscher, Ioav Cabantchik, Paolo Carloni, Ron Mittler, Oded Livnah, Eric Meldrum, Rachel Nechushtai

Publikováno v: Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)

Marjault et al. report two crystal structures of a drug molecule bound to NEET proteins mNT and NAF-1 and the effects of this molecule on diabetic mice, suggesting an approach for reducing mitochondrial iron and ROS levels in diabetic patients.

Externí odkaz: https://doaj.org/article/5fdc9f8e63f74c36ac4f3fdb8fd0831a

Mitochondrial morphodynamics alteration induced by influenza virus infection as a new antiviral strategy.

Autor: Irene Pila-Castellanos, Diana Molino, Joe McKellar, Laetitia Lines, Juliane Da Graca, Marine Tauziet, Laurent Chanteloup, Ivan Mikaelian, Laurène Meyniel-Schicklin, Patrice Codogno, Jacky Vonderscher, Cédric Delevoye, Olivier Moncorgé, Eric Meldrum, Caroline Goujon, Etienne Morel, Benoit de Chassey

Publikováno v: PLoS Pathogens, Vol 17, Iss 2, p e1009340 (2021)

Influenza virus infections are major public health threats due to their high rates of morbidity and mortality. Upon influenza virus entry, host cells experience modifications of endomembranes, including those used for virus trafficking and replicatio

Externí odkaz: https://doaj.org/article/811c473002d34a5981e5034b7202dc51

Chemical targeting of NEET proteins reveals their function in mitochondrial morphodynamics

Autor: Ahmed Hamaï, Nivea Dias Amoedo, Francesca Giordano, Yang Sung Sohn, Peter Machin, Benoît de Chassey, Diana Molino, Patrice Codogno, Ola Karmi, Henri-Baptiste Marjault, Laetitia Lines, Irene Pila-Castellanos, Alessia Ruggieri, Damien Arnoult, Pauline Radreau, Rodrigue Rossignol, Etienne Morel, Eric Meldrum, Leila Rochin, Jacky Vonderscher, Rachel Nechushtai, Stéphane Joly, Katja Kopp

Publikováno v: EMBO Rep
EMBO Reports
EMBO Reports, EMBO Press, 2020, 21 (12), ⟨10.15252/embr.201949019⟩
EMBO Reports, EMBO Press, 2020, ⟨10.15252/embr.201949019⟩

International audience; Several human pathologies including neurological, cardiac, infectious , cancerous, and metabolic diseases have been associated with altered mitochondria morphodynamics. Here, we identify a small organic molecule, which we name

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05b0954eedbb6d731ad6194e35c1b2c
https://pubmed.ncbi.nlm.nih.gov/33180995

Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance

Autor: Ashish Kurundkar, Thomas D. Hock, Louise Hecker, Eric Meldrum, Victor J. Thannickal, Naomi J. Logsdon, Deepali Kurundkar, Yan Y. Sanders, Karen Bernard

Publikováno v: Science translational medicine. 6(231)

The incidence and prevalence of pathological fibrosis increase with advancing age, although mechanisms for this association are unclear. We assessed the capacity for repair of lung injury in young (2 months) and aged (18 months) mice. Whereas the sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde573396fc682e58660b2dc7ca0fbae
https://pubmed.ncbi.nlm.nih.gov/25668226

Phospholipases in yeast

Autor: Catherine N. Torgler, Mariastella de Tiani, Eric Meldrum

Publikováno v: Seminars in Cell & Developmental Biology. 8:333-338

The central role that different phospholipases play in many signal transduction pathways has been intensively studied by classical biochemical and molecular approaches. One approach not extensively pursued, has been the use of yeast as a model system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817aa6b4180d7764e0fde5f6ecf6d4ce
https://doi.org/10.1006/scdb.1997.0155