Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Eric, Marsault"'
Autor:
David Coquerel, Julie Lamoureux, Frédéric Chagnon, Kien Trân, Michael Sage, Etienne Fortin-Pellerin, Eugénie Delile, Xavier Sainsily, Justin Fournier, Audrey-Ann Dumont, Mannix Auger-Messier, Philippe Sarret, Eric Marsault, Jean-Paul Praud, Tamàs Fülöp, Olivier Lesur
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Sepsis is a prevalent life-threatening condition related to a systemic infection, and with unresolved issues including refractory septic shock and organ failures. Endogenously released catecholamines are often inefficient to maintain blood p
Externí odkaz:
https://doaj.org/article/01d655baf6da4408a83a36f90f682b23
Autor:
Isabelle Guay, Simon Boulanger, Charles Isabelle, Eric Brouillette, Félix Chagnon, Kamal Bouarab, Eric Marsault, François Malouin
Publikováno v:
BMC Pharmacology and Toxicology, Vol 19, Iss 1, Pp 1-12 (2018)
Abstract Background Tomatidine (TO) is a plant steroidal alkaloid that possesses an antibacterial activity against the small colony variants (SCVs) of Staphylococcus aureus. We report here the spectrum of activity of TO against other species of the B
Externí odkaz:
https://doaj.org/article/e95719d96bb745b0adf36f969769c0e3
Autor:
Tirosh Shapira, I. Abrrey Monreal, Sébastien P. Dion, David W. Buchholz, Brian Imbiakha, Andrea D. Olmstead, Mason Jager, Antoine Désilets, Guang Gao, Mathias Martins, Thierry Vandal, Connor A. H. Thompson, Aaleigha Chin, William D. Rees, Theodore Steiner, Ivan Robert Nabi, Eric Marsault, Julie Sahler, Diego G. Diel, Gerlinde R. Van de Walle, Avery August, Gary R. Whittaker, Pierre-Luc Boudreault, Richard Leduc, Hector C. Aguilar, François Jean
Publikováno v:
Nature. 605:340-348
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced owing to emerging variants of concern1,2. Development of host-directed thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9dca545d7fbe19dcbebd61e81a4589
https://doi.org/10.1038/s41586-022-04661-w
https://doi.org/10.1038/s41586-022-04661-w
Autor:
Léa Théroux, Robin Van Den Hauwe, Kien Trân, Justin Fournier, Michael Desgagné, Nathan Meneboo, Alexis Lavallée, Ulrike Fröhlich, Jérôme Côté, Charlie Hollanders, Jean-Michel Longpré, Alexandre Murza, Eric Marsault, Philippe Sarret, Pierre-Luc Boudreault, Steven Ballet
Apelin is an endogenous peptide that is involved in many diseases such as cardiovascular diseases, obesity, and cancer, which has made it an attractive target for drug discovery. Herein, we explore the penultimate and final sequence positions of [Pyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15bd1073741ed01a6adbbcbf500ae054
https://doi.org/10.1021/acsptsci.2c00219
https://doi.org/10.1021/acsptsci.2c00219
Autor:
Jean-Paul Praud, Eric Marsault, Xavier Sainsily, David Coquerel, Frederic Chagnon, Eugénie Delile, Mannix Auger-Messier, Audrey-Ann Dumont, Tamas Fulop, Etienne Fortin-Pellerin, Michaël Sage, Philippe Sarret, Kien Trân, Julie Lamoureux, Olivier Lesur, Justin Fournier
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Sepsis is a prevalent life-threatening condition related to a systemic infection, and with unresolved issues including refractory septic shock and organ failures. Endogenously released catecholamines are often inefficient to maintain blood pressure,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c86bec1296d4c2b5a85bfeda9847dce0
https://doaj.org/article/01d655baf6da4408a83a36f90f682b23
https://doaj.org/article/01d655baf6da4408a83a36f90f682b23
Autor:
Emmeran Le Moal, Yuguo Liu, Jasmin Collerette-Tremblay, Simon Dumontier, Joël Boutin, Junio Dort, Zakaria Orfi, Joris Michaud, Hugo Giguère, Alexandre Desroches, Kien Trân, François Vézina, Sonia Bedard, Catherine Raynaud, Frederic Balg, Philippe Sarret, Michelle S. Scott, Jerome N. Feige, Jean-Bernard Denault, Nicolas A. Dumont, Eric Marsault, Mannix Auger-Messier, C. Florian Bentzinger
Impaired skeletal muscle stem cell (MuSC) function has long been suspected to contribute to the pathogenesis of muscular dystrophy (MD). Here we describe that defects in the endothelial cell (EC) compartment of the perivascular stem cell niche in thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93ef9e1393dd6bc0f84458d9e32277c0
https://doi.org/10.1101/2022.09.09.507274
https://doi.org/10.1101/2022.09.09.507274
Autor:
Michel Paquette, Luis-Guillermo Vilera-Perez, Simon Beaudoin, Nadia Ekindi-Ndongo, Pierre-Luc Boudreaut, Marc-Andre Bonin, Marie-Claude Battista, M'hamed Bentourkia, Angel F. Lopez, Roger Lecomte, Eric Marsault, Brigitte Guérin, Robert Sabbagh, Jeffrey V. Leyton
Publikováno v:
OncoImmunology, Vol 6, Iss 10 (2017)
Despite the high interest and concern due to an increasing incidence and death rate, patients who develop muscle invasive bladder cancer (MIBC) have few options available. However, the past decade has produced many candidate bladder tumor-specific ma
Externí odkaz:
https://doaj.org/article/39ceb8d0e9154c49a04dea5569cdba7a
Autor:
Eric Marsault, Robin Van Den Hauwe, Claude Spino, Sabrina Saibi, Xavier Sainsily, Jérôme Côté, Louise Simard, Alexandra Serre, Michel Bouvier, Steven Ballet, Mannix Auger-Messier, Jean-Michel Longpré, Lounès Haroune, Pierre Couvineau, Olivier Lesur, Alexandre Murza, Marco Echevarria, Kien Trân, Léa Théroux, Philippe Sarret
Publikováno v:
Journal of Medicinal Chemistry. 64:5345-5364
Side-chain-constrained amino acids are useful tools to modulate the biological properties of peptides. In this study, we applied side-chain constraints to apelin-13 (Ape13) by substituting the Pro12 and Phe13 positions, affecting the binding affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6326583d9752754accc55d2ff5cb76
https://doi.org/10.1021/acs.jmedchem.0c01941
https://doi.org/10.1021/acs.jmedchem.0c01941
Autor:
Sébastien P. Dion, Alexandre Murza, Pierre-Luc Boudreault, Eric Marsault, Richard Leduc, Antoine Désilets
Publikováno v:
Expert Opinion on Therapeutic Patents
Type II transmembrane serine proteases (TTSPs) of the human respiratory tract generate high interest owing to their ability, among other roles, to cleave surface proteins of respiratory viruses. This step is critical in the viral invasion of coronavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773961ec6ac364fd6b22d9272870375e
https://doi.org/10.1080/13543776.2020.1817390
https://doi.org/10.1080/13543776.2020.1817390
Autor:
Matthias Beat Wittwer, Dieudonné Tshitenge Tshitenge, Pierre-Luc Boudreault, Annie Doucet, Maximilian Kullmann, Joachim Mittendorf, Émilie Blaise, Florian Kölling, Alexander Hillisch, Christian Comeau, Marie-Pierre Collin, Lea Seep, Eric Marsault, Andreas H. Göller, Antoine Le Roux, Marilena Giarrusso, Thomas Neubauer
Publikováno v:
Journal of Medicinal Chemistry. 63:6774-6783
We herein report the first thorough analysis of the structure-permeability relationship of semipeptidic macrocycles. In total, 47 macrocycles were synthesized using a hybrid solid-phase/solution strategy, and then their passive and cellular permeabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0233d450b6d70f6daea1d2fd2c80ac76
https://doi.org/10.1021/acs.jmedchem.0c00013
https://doi.org/10.1021/acs.jmedchem.0c00013