Rôle du néphron distal dans le contrôle du volume extracellulaire en condition physiologique et dans le syndrome néphrotique

Autor: Eric Féraille, Valérie Olivier

Publikováno v: médecine/sciences. 37:359-365

The kidney plays a major role to maintain the constancy of the "milieu interieur" by adjusting the urinary excretion of water and solutes to the requirement of the body balance. This function is coordinated with elimination of waste products generate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ab1b4f512a56a04acf609496d59acd6
https://doi.org/10.1051/medsci/2021032

Activation of the Hypoxia-Inducible Factor Pathway Inhibits Epithelial Sodium Channel–Mediated Sodium Transport in Collecting Duct Principal Cells

Autor: Brenda R. Kwak, Suresh Ramakrishnan, Valérie Olivier, Edith Hummler, Johannes Loffing, Isabelle Roth, Roland H. Wenger, Eva Dizin, Gregoire Arnoux, Sandrine Morel, Ali Sassi, Ian J. Frew, Eric Féraille

Publikováno v: J Am Soc Nephrol
Journal of the American Society of Nephrology, Vol. 32, No 12 (2021) pp. 3130-3145

Background: Active sodium reabsorption is the major factor influencing renal oxygen consumption and production of reactive oxygen species (ROS). Increased sodium reabsorption uses more oxygen, which may worsen medullary hypoxia and produce more ROS v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60a156f506f36ad667912e7d6ab4122
https://europepmc.org/articles/PMC8638392/

NADPH oxidase 4 deficiency reduces aquaporin-2 mRNA expression in cultured renal collecting duct principal cells via increased PDE3 and PDE4 activity.

Autor: Eric Féraille, Eva Dizin, Isabelle Roth, Jean-Paul Derouette, Ildiko Szanto, Pierre-Yves Martin, Sophie de Seigneux, Udo Hasler

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87239 (2014)

The final control of renal water reabsorption occurs in the collecting duct (CD) and relies on regulated expression of aquaporin-2 (AQP2) in principal CD cells. AQP2 transcription is primarily induced by type 2 vasopressin receptor (V2R)-cAMP-protein

Externí odkaz: https://doaj.org/article/8c58c0c7fb4d476d9cf8dd2bb95c51ed

Plasma volume contraction reduces atrial natriuretic peptide after four days of hypobaric hypoxia exposure

Autor: Maja Schlittler, Giacomo Strapazzon, Hannes Gatterer, Simon Woyke, Eric Féraille, Ivo B Regli, Christoph Siebenmann, Jens P. Goetze, Hermann Brugger, Rachel Turner, Simon Rauch

Publikováno v: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 320, No 4 (2021) pp. R526-R531

We investigated whether low arterial oxygen tension ([Formula: see text]) or hypoxia-induced plasma volume (PV) contraction, which reduces central blood volume (BV) and atrial distension, explain reduction in circulating atrial natriuretic peptide (A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56409ee7a00d86123ce30f1c712c2c3f
https://archive-ouverte.unige.ch/unige:158380

Regulation of plasma volume in male lowlanders during 4 days of exposure to hypobaric hypoxia equivalent to 3500 m altitude

Autor: Giacomo Strapazzon, Gerrit van Hall, Maja Schlittler, Eric Féraille, Rachel Turner, Michael Kob, Jens P. Goetze, Simon Woyke, Ivo B Regli, Peter Vestergaard Rasmussen, Christoph Siebenmann, Marc Maillard, Hannes Gatterer, Thomas Mueller

Publikováno v: The Journal of physiology, vol. 599, no. 4, pp. 1083-1096
Schlittler, M, Gatterer, H, Turner, R, Regli, I B, Woyke, S, Strapazzon, G, Rasmussen, P, Kob, M, Mueller, T, Goetze, J P, Maillard, M, van Hall, G, Feraille, E & Siebenmann, C 2021, ' Regulation of plasma volume in male lowlanders during 4 days of exposure to hypobaric hypoxia equivalent to 3500 m altitude ', The Journal of Physiology, vol. 599, no. 4, pp. 1083-1096 . https://doi.org/10.1113/JP280601

Key pointsAcclimatization to hypoxia leads to a reduction in plasma volume (PV) that restores arterial O-2 content.Findings from studies investigating the mechanisms underlying this PV contraction have been controversial, possibly as experimental con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ad6e8be68bb213f25d1fd516ac7627
https://pubmed.ncbi.nlm.nih.gov/33590893