Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Eric, Detrait"'
Publikováno v:
Journal of Neuroscience Methods. 268:182-188
Background Set-shifting tests represent a reliable paradigm to assess executive functions in humans and animals. In the rat, set-shifting in a cross-maze is a recognized method. In this test, rats must learn an egocentric rule to locate food reinforc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e203add19e23d1c2d3687896927b0f0f
https://doi.org/10.1016/j.jneumeth.2015.08.012
https://doi.org/10.1016/j.jneumeth.2015.08.012
Publikováno v:
Pharmaceutical Statistics. 15:277-285
Whilst innovative Bayesian approaches are increasingly used in clinical studies, in the preclinical area Bayesian methods appear to be rarely used in the reporting of pharmacology data. This is particularly surprising in the context of regularly repe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a433e162e0c3c2ba9a1e87226094302b
https://doi.org/10.1002/pst.1748
https://doi.org/10.1002/pst.1748
Publikováno v:
Behavioural Brain Research
Behavioural Brain Research, Elsevier, 2014, 271, pp.277-285. ⟨10.1016/j.bbr.2014.06.013⟩
Behavioural Brain Research, Elsevier, 2014, 271, pp.277-285. ⟨10.1016/j.bbr.2014.06.013⟩
International audience; SV2B is a synaptic protein widely distributed throughout the brain, which is part of the complex vesicle protein machinery involved in the regulation of synaptic vesicle endocytosis and exocytosis, and therefore in neurotransm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f896a46cba45653f5070e6e2d8c3e8
https://doi.org/10.1016/j.bbr.2014.06.013
https://doi.org/10.1016/j.bbr.2014.06.013
Autor:
Rosalind, Walley, John, Sherington, Joe, Rastrick, Eric, Detrait, Etienne, Hanon, Gillian, Watt
Publikováno v:
Pharmaceutical statistics. 15(3)
Whilst innovative Bayesian approaches are increasingly used in clinical studies, in the preclinical area Bayesian methods appear to be rarely used in the reporting of pharmacology data. This is particularly surprising in the context of regularly repe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89998c35c2d3a3a4580b09ef944a1846
https://pubmed.ncbi.nlm.nih.gov/27028721
https://pubmed.ncbi.nlm.nih.gov/27028721
Publikováno v:
Fundamental & Clinical Pharmacology. 27:354-363
We used conscious tethered Sprague-Dawley rats to evaluate the cardiovascular effects of four sigma-1 (r1) agonists and five antagonists, given alone or in combination. All drugs were administered as a single intraperitoneal dose. The agonists were g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0be9667b9d42c110df611a977f00818
https://doi.org/10.1111/j.1472-8206.2012.01042.x
https://doi.org/10.1111/j.1472-8206.2012.01042.x
Autor:
Laurent Provins, Michel Gillard, Christel Delaunoy, Frédéric Denonne, Sabine Defays, Jean-Marie Nicolas, Geneviève Lorent, Eric Detrait, Véronique Durieu, Bernard Christophe, Yves Lamberty, Alain Vanbellinghen, Nathalie Van houtvin, Sylvain Celanire, Marie-Laure Delporte
Publikováno v:
ChemMedChem. 6:1559-1565
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d838126cb62c79dcc6d4c0028d307312
https://doi.org/10.1002/cmdc.201100248
https://doi.org/10.1002/cmdc.201100248
Autor:
Michel Guyaux, Anne Valade, Celine Vermeiren, Nivedita Namdev, Michel Gillard, Yves Lamberty, Doina Ene, Sophie Binet Cross, Eric Schwartz, Eric Detrait, Laurent Provins, Claire Brown, Martin Maguire
Publikováno v:
MedChemComm. 2:655-660
We disclose the identification and SAR of phenylcyclopropylcarboxamide compounds as novel, selective Sigma-1 ligands presenting excellent drug-like properties, high solubility and metabolic stability. A selected representative, compound 14, demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02447063551f00e5a4a32242ff8c89dc
https://doi.org/10.1039/c1md00010a
https://doi.org/10.1039/c1md00010a
Autor:
Yves Lamberty, Karine Leclercq, Etienne Hanon, Eric Detrait, Alain Matagne, Rafal M. Kaminski, Wolfgang Löscher, Isabelle Niespodziany, Heidrun Potschka
Publikováno v:
Epilepsy Research. 91:74-83
Summary Several antiepileptic drugs (AEDs) may induce memory deficits when tested in preclinical models at doses that exert significant protection against seizures. Brivaracetam (BRV) is a novel high-affinity SV2A ligand also displaying inhibitory ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10abe6575a97bac7dbd442fd05db67ed
https://doi.org/10.1016/j.eplepsyres.2010.06.014
https://doi.org/10.1016/j.eplepsyres.2010.06.014
Publikováno v:
Behavior Research Methods. 41:805-811
In the present article, we describe a new protocol for the inhibitory avoidance test, with a dual purpose: (1) to provide a less variable and more reliable assessment of the efficacy of potential cognitive enhancers in antagonizing scopolamine-induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc175610dd0bb945b34d82d8f349bd3e
https://doi.org/10.3758/brm.41.3.805
https://doi.org/10.3758/brm.41.3.805
Publikováno v:
Behavioural Brain Research. 198:329-333
Synaptic vesicle protein 2A (SV2A) is involved in neurotransmitter release and has been identified as the binding site for levetiracetam (Keppra®), a novel antiepileptic drug. Homozygous SV2A (−/−) mice are not viable beyond a few weeks. In cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b07741d845ae98eb903b2bf9c7132d3
https://doi.org/10.1016/j.bbr.2008.11.005
https://doi.org/10.1016/j.bbr.2008.11.005