Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Eri SAKAI"'
Autor:
Baasanjav Uranbileg, Eri Sakai, Masayuki Kubota, Hideaki Isago, Masahiko Sumitani, Yutaka Yatomi, Makoto Kurano
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Mass spectrometry-based lipidomics approaches offer valuable tools for the detection and quantification of various lipid species, including sphingolipids. The present study aimed to develop a new method to simultaneously detect various sphin
Externí odkaz:
https://doaj.org/article/b216bbc5511c4397b54fee729e722fc8
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
IntroductionAlzheimer’s disease (AD) is associated with disturbed metabolism, prompting investigations into specific metabolic pathways that may contribute to its pathogenesis and pathology. Sphingolipids have garnered attention due to their known
Externí odkaz:
https://doaj.org/article/db3b26a9d92044b88c9abaca2ce817d6
Publikováno v:
Frontiers in Nephrology, Vol 4 (2024)
BackgroundTo avoid an invasive renal biopsy, noninvasive laboratory testing for the differential diagnosis of kidney diseases is a desirable goal. As sphingolipids are demonstrated to be involved in the pathogenesis of various kidney diseases, we inv
Externí odkaz:
https://doaj.org/article/2add16f4c97f4a6caf8527f0d2fa0217
Autor:
Tomoyo Yamashita, Junko Hotta, Yukiko Jogu, Eri Sakai, Chie Ono, Haruka Bamba, Hisato Suzuki, Mamiko Yamada, Toshiki Takenouchi, Kenjiro Kosaki, Tohru Yorifuji, Takashi Hamazaki, Toshiyuki Seto
Publikováno v:
Human Genome Variation, Vol 10, Iss 1, Pp 1-4 (2023)
Abstract Oculofaciocardiodental syndrome is caused by variants in the BCL6 corepressor (BCOR) gene. We identified a novel heterozygous frameshift variant, NM_001123385.2(BCOR):c.2326del, that arose de novo in a Japanese girl with characteristic facia
Externí odkaz:
https://doaj.org/article/0c330a9423084e169edb2dba82c09105
Autor:
Makoto Kurano, Daisuke Jubishi, Koh Okamoto, Hideki Hashimoto, Eri Sakai, Yoshifumi Morita, Daisuke Saigusa, Kuniyuki Kano, Junken Aoki, Sohei Harada, Shu Okugawa, Kent Doi, Kyoji Moriya, Yutaka Yatomi
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-18 (2022)
Abstract Background Among various complications of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), renal complications, namely COVID-19-associated kidney injuries, are related to the mortal
Externí odkaz:
https://doaj.org/article/8068e1f7d8d34721ab51aca8725df7b4
Publikováno v:
Cancer Medicine, Vol 11, Iss 18, Pp 3491-3507 (2022)
Abstract Background Numerous studies have investigated the possible involvement of eicosanoids, lysophospholipids, and sphingolipids in cancer. We considered that comprehensive measurement of these lipid mediators might provide a better understanding
Externí odkaz:
https://doaj.org/article/bc25b40aa99f490182c438d1fbc8f415
Autor:
Makoto Kurano, Koh Okamoto, Daisuke Jubishi, Hideki Hashimoto, Eri Sakai, Daisuke Saigusa, Kuniyuki Kano, Junken Aoki, Sohei Harada, Shu Okugawa, Kent Doi, Kyoji Moriya, Yutaka Yatomi
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 10, Pp n/a-n/a (2022)
Abstract Background A heterogeneous clinical phenotype is a characteristic of coronavirus disease 2019 (COVID‐19). Therefore, investigating biomarkers associated with disease severity is important for understanding the mechanisms responsible for th
Externí odkaz:
https://doaj.org/article/e4633a865ad241c08a743fa4fcebc792
Autor:
Baasanjav Uranbileg, Makoto Kurano, Kuniyuki Kano, Eri Sakai, Junichi Arita, Kiyoshi Hasegawa, Takeshi Nishikawa, Soichiro Ishihara, Hiroharu Yamashita, Yasuyuki Seto, Hitoshi Ikeda, Junken Aoki, Yutaka Yatomi
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 9, Pp n/a-n/a (2022)
Abstract Background In addition to potent agonist properties for sphingosine 1‐phosphate (S1P) receptors, intracellularly, S1P is an intermediate in metabolic conversion pathway from sphingolipids to glycerolysophospholipids (glyceroLPLs). We hypot
Externí odkaz:
https://doaj.org/article/5cd81ea249b54027a2296d0bd8c846ea
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Both gain-of-function of mutant p53 (GOF) and loss of wild-type p53 (LOH) are independently associated with cancer. Here, the authors show that LOH promotes GOF tumourigenesis by increasing tumor-initiating ability and metastasis.
Externí odkaz:
https://doaj.org/article/8d1fffa592274a9e92de86ee38fb2d03
Autor:
Yoshifumi Morita, Makoto Kurano, Eri Sakai, Takako Nishikawa, Masako Nishikawa, Motoji Sawabe, Junken Aoki, Yutaka Yatomi
Publikováno v:
Journal of Diabetes Investigation, Vol 11, Iss 2, Pp 441-449 (2020)
Abstract Aims/Introduction Sphingolipids, such as ceramides and sphingosine, are involved in the pathogenesis of diabetes; however, the modulation of urinary sphingolipids in diabetic nephropathy has not been fully elucidated. Therefore, we aimed to
Externí odkaz:
https://doaj.org/article/18a1d2340e324946b7f0b98bcaec1ea4