Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Eri Kanaoka"'
Publikováno v:
Xenobiotica. 45:60-70
1. Plasma clearance of dolutegravir, an unboosted HIV-1 integrase inhibitor, was low in rat and monkey (0.23 and 2.12 mL/min/kg, respectively) as was the volume of distribution (0.1 and 0.28 L/kg, respectively) with terminal elimination half-life app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037d800f1bc43986c18603e2ce1d3fa1
https://doi.org/10.3109/00498254.2014.942409
https://doi.org/10.3109/00498254.2014.942409
Autor:
Paul M. Savina, Joseph W. Polli, Eri Kanaoka, Grant T. Generaux, James D. Clarke, Kelly A. Harmon, Helen Tracey, Melinda J. Reese, Joan E. Humphreys, Lindsey O. Webster
Publikováno v:
Drug Metabolism and Disposition. 41:353-361
Dolutegravir (DTG; S/GSK1349572) is a potent HIV-1 integrase inhibitor with a distinct resistance profile and a once-daily dose regimen that does not require pharmacokinetic boosting. This work investigated the in vitro drug transport and metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993f8bf7610b57cb92f53b9a937dadea
https://doi.org/10.1124/dmd.112.048918
https://doi.org/10.1124/dmd.112.048918
Publikováno v:
Drug Delivery System. 23:460-466
経肺投与は，さまざまな肺疾患に対してきわめて効率のよい薬物投与が期待されるが，製剤をリポソーム化することによって，さらに魅力的な製剤を設計することができる．リポソーム
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4fb70836c19270b9bfaaa4bf2ee29ea
https://doi.org/10.2745/dds.23.460
https://doi.org/10.2745/dds.23.460
Autor:
Koichiro Hirano, Hiroaki Jizomoto, Naomi Uchida, Eri Kanaoka, Ryuji Maekawa, Kouji Takahashi, Yoshitaka Nishihara, Takayoshi Yoshikawa
Publikováno v:
Journal of Controlled Release. 82:183-187
Recombinant interleukin-2 (IL-2) was strongly and almost completely adsorbed onto small hydrophobic liposomes under optimal conditions (liposome: DSPC-DSPG; molar ratio, 10:1; 30-50 nm in size, ratio of IL-2 to liposome: 4.0 JRU/nmol lipid). This lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a305ca76e3078e7b0005f7fbdc1051
https://doi.org/10.1016/s0168-3659(02)00083-4
https://doi.org/10.1016/s0168-3659(02)00083-4
Autor:
Kohsaku Kawakami, Yoshitaka Nishihara, Yasushi Moroto, Koji Takahashi, Eri Kanaoka, Kazuyoshi Masuda, Takayoshi Yoshikawa
Publikováno v:
Journal of Controlled Release. 81:65-74
Microemulsion formulations, which can be used to improve the bioavailability of poorly soluble drugs, were designed using only pharmaceutical excipients. Several types of oils and surfactants were tested and it was found that propyleneglycol monoalky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca547b6dcd4890a4d80bb36500f50dc3
https://doi.org/10.1016/s0168-3659(02)00049-4
https://doi.org/10.1016/s0168-3659(02)00049-4
Publikováno v:
International Journal of Pharmaceutics. 188:165-172
Aerosolized IFN-gamma is very unstable. We have improved the stability of IFN-gamma in the jet nebulizer by adding small liposomes. Aerosolized IFN-gamma was recovered in PBS solution by bubbling and its concentration was determined. After nebulizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bdca275e67589c7f1f659cafdd2f7c
https://doi.org/10.1016/s0378-5173(99)00218-5
https://doi.org/10.1016/s0378-5173(99)00218-5
Autor:
Mitsuru Notoya, Takayuki Kuroda, Eri Kanaoka, Hiroyuki Okamoto, Toshihiro Shinosaki, Yoshinori Tamura, Masao Masui, Masashi Ito
Publikováno v:
Nephron Extra
Nephron Extra, Vol 2, Iss 1, Pp 133-146 (2012)
Nephron Extra, Vol 2, Iss 1, Pp 133-146 (2012)
Background/Aim: Matrix metalloproteinases (MMPs) play pivotal roles in extracellular matrix turnover and are involved in chronic kidney disease. The renoprotective action of a synthetic MMP inhibitor, compound A, was investigated in chronic nephritis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2c9d90f02e606e6ae7bd3b75a9fcf7b
https://pubmed.ncbi.nlm.nih.gov/22739248
https://pubmed.ncbi.nlm.nih.gov/22739248
Publikováno v:
Pharmaceutical Research. 10:1115-1122
Nonhardened gelatin-acacia microcapsules were studied for encapsulation of microdroplets of oil solution containing a lipophilic drug as core material and ready disintegration with release of micro oil droplets in the gastrointestinal tract. Probucol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19e1ef299d119379233ec545cf4cdaa9
https://doi.org/10.1023/a:1018951814939
https://doi.org/10.1023/a:1018951814939
Autor:
Shuichi Ohnishi, Noboru Okamura, Ryo Norikura, Kiyoshi Sakamoto, Takahiko Baba, Hiroshi Hasegawa, Kouji Takahashi, Eri Kanaoka, Shingo Sakamoto, Kazutoshi Horie
Publikováno v:
Drug metabolism and pharmacokinetics. 23(4)
Pivalic acid and valproic acid decreases L-carnitine concentration in the body via urinary excretion of their acylcarnitines, pivaloylcarnitine (PC) and valproylcarnitine (VC). To obtain an information about the mechanism of the physiological respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::874a79791ba62c2d0ab057b836c8e80e
https://pubmed.ncbi.nlm.nih.gov/18762717
https://pubmed.ncbi.nlm.nih.gov/18762717
Autor:
Hiroaki Jizomoto, Eri Kanaoka, Koichiro Hirano, Yoshitaka Nishihara, Kouji Takahashi, Takayoshi Yoshikawa
Publikováno v:
Drug development and industrial pharmacy. 29(10)
Recombinant interleukin-2 (IL-2) was strongly and almost completely adsorbed onto small and hydrophobic liposomes by simple mixing under optimal conditions (liposome: DSPC-DSPG; molar ratio, 10:1; 30-50 nm in size, ratio of IL-2 to liposome: 4.0 JRU/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b06f3f8c4511864f2d08092d827c185
https://pubmed.ncbi.nlm.nih.gov/14677775
https://pubmed.ncbi.nlm.nih.gov/14677775