Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Eri Atsumi"'
Autor:
Yoshiyuki Sugimoto, Yozo Kojima, Atsushi Inayoshi, Kazuaki Inoue, Hiroko Miura-Kusaka, Kiyotoshi Mori, Osamu Saku, Hiroshi Ishida, Eri Atsumi, Yoshisuke Nakasato, Shiro Shirakura, Shin-ichiro Toki, Katsumi Shinoda, Nobuyuki Suzuki
Publikováno v:
Journal of Pharmacological Sciences, Vol 123, Iss 3, Pp 256-266 (2013)
Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable non-selective cation channel that transmits pain signals. TRPV1 is activated by multiple stimuli such as capsaicin, acid, and heat. During inflammation, TRPV1 is reported to be sens
Externí odkaz:
https://doaj.org/article/d34e73b9e5ae401c9b528731d20585d5
Autor:
Hiroshi Kodaira, Osamu Saku, Yoshimitsu Kato, Yoshisuke Nakasato, Yoshiyuki Sugimoto, Eri Atsumi, Shiro Shirakura, Hiroshi Ishida
Publikováno v:
Journal of Medicinal Chemistry. 55:3436-3451
We have developed a novel and potent chemical series of 5,5-diphenylpentadienamides for targeting TRPV1 in vitro and in vivo. In this investigation, we examined a variety of replacements for the 5-position of dienamides with the goal of addressing is